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Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice

Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice
Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice

A cornerstone technique in the study of hearing is the Auditory Brainstem Response (ABR), an electrophysiologic technique that can be used as a quantitative measure of hearing function. Previous studies have published databases of baseline ABR thresholds for mouse strains, providing a valuable resource for the study of baseline hearing function and genetic mapping of hearing traits in mice. In this study, we further expand upon the existing literature by characterizing the baseline ABR characteristics of 100 inbred mouse strains, 47 of which are newly characterized for hearing function. We identify several distinct patterns of baseline hearing deficits and provide potential avenues for further investigation. Additionally, we characterize the sensitivity of the same 100 strains to noise exposure using permanent thresholds shifts, identifying several distinct patterns of noise-sensitivity. The resulting data provides a new resource for studying hearing loss and noise-sensitivity in mice.

Acoustic Stimulation, Animals, Auditory Fatigue, Brain Stem, Disease Models, Animal, Evoked Potentials, Auditory, Brain Stem, Genetic Predisposition to Disease, Hearing, Hearing Loss, Noise-Induced, Hearing Tests, Noise, Phenotype, Species Specificity, Comparative Study, Journal Article, Research Support, N.I.H., Extramural
0378-5955
113-120
Myint, Anthony
e8e075d8-fea8-4662-8ddb-85691513625d
White, Cory H.
45233a78-f0c9-4696-8aaf-1b2673f83c91
Ohmen, Jeffrey D.
072b2de5-d335-4ba5-bc40-51744fbc1f92
Li, Xin
50870cd7-3ec3-434e-a43a-b10d50e3d5b3
Wang, Juemei
c218cf75-9f66-4537-a71b-dc4e257654b4
Lavinsky, Joel
e0ee2538-ada7-4b12-b406-cc54a81e57b3
Salehi, Pezhman
49a93097-8239-4c44-a371-6b853a64a648
Crow, Amanda L.
7742158b-f978-42a4-8566-3f21c140ac6a
Ohyama, Takahiro
3e5dc7cd-c625-4d04-99d1-13b738c2855c
Friedman, Rick A.
1500f8c3-af23-4558-bf96-b045fc280997
Myint, Anthony
e8e075d8-fea8-4662-8ddb-85691513625d
White, Cory H.
45233a78-f0c9-4696-8aaf-1b2673f83c91
Ohmen, Jeffrey D.
072b2de5-d335-4ba5-bc40-51744fbc1f92
Li, Xin
50870cd7-3ec3-434e-a43a-b10d50e3d5b3
Wang, Juemei
c218cf75-9f66-4537-a71b-dc4e257654b4
Lavinsky, Joel
e0ee2538-ada7-4b12-b406-cc54a81e57b3
Salehi, Pezhman
49a93097-8239-4c44-a371-6b853a64a648
Crow, Amanda L.
7742158b-f978-42a4-8566-3f21c140ac6a
Ohyama, Takahiro
3e5dc7cd-c625-4d04-99d1-13b738c2855c
Friedman, Rick A.
1500f8c3-af23-4558-bf96-b045fc280997

Myint, Anthony, White, Cory H., Ohmen, Jeffrey D., Li, Xin, Wang, Juemei, Lavinsky, Joel, Salehi, Pezhman, Crow, Amanda L., Ohyama, Takahiro and Friedman, Rick A. (2016) Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice. Hearing Research, 332, 113-120. (doi:10.1016/j.heares.2015.12.006).

Record type: Article

Abstract

A cornerstone technique in the study of hearing is the Auditory Brainstem Response (ABR), an electrophysiologic technique that can be used as a quantitative measure of hearing function. Previous studies have published databases of baseline ABR thresholds for mouse strains, providing a valuable resource for the study of baseline hearing function and genetic mapping of hearing traits in mice. In this study, we further expand upon the existing literature by characterizing the baseline ABR characteristics of 100 inbred mouse strains, 47 of which are newly characterized for hearing function. We identify several distinct patterns of baseline hearing deficits and provide potential avenues for further investigation. Additionally, we characterize the sensitivity of the same 100 strains to noise exposure using permanent thresholds shifts, identifying several distinct patterns of noise-sensitivity. The resulting data provides a new resource for studying hearing loss and noise-sensitivity in mice.

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More information

Accepted/In Press date: 7 December 2015
e-pub ahead of print date: 17 December 2015
Published date: February 2016
Keywords: Acoustic Stimulation, Animals, Auditory Fatigue, Brain Stem, Disease Models, Animal, Evoked Potentials, Auditory, Brain Stem, Genetic Predisposition to Disease, Hearing, Hearing Loss, Noise-Induced, Hearing Tests, Noise, Phenotype, Species Specificity, Comparative Study, Journal Article, Research Support, N.I.H., Extramural

Identifiers

Local EPrints ID: 413748
URI: http://eprints.soton.ac.uk/id/eprint/413748
ISSN: 0378-5955
PURE UUID: e9363304-eddb-4c8b-94ea-e9306ee713e6

Catalogue record

Date deposited: 04 Sep 2017 16:30
Last modified: 06 Oct 2020 23:48

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Contributors

Author: Anthony Myint
Author: Cory H. White
Author: Jeffrey D. Ohmen
Author: Xin Li
Author: Juemei Wang
Author: Joel Lavinsky
Author: Pezhman Salehi
Author: Amanda L. Crow
Author: Takahiro Ohyama
Author: Rick A. Friedman

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