Cancer detection and tissue of origin determination with novel annotation and scoring of cell-free methylated DNA
Cancer detection and tissue of origin determination with novel annotation and scoring of cell-free methylated DNA
In a recent paper, Guo et al. (1) analysed the methylation of DNA fragments circulating in the blood plasma that are released when cells die. Their analysis used a novel approach to annotate DNA methylation and a methylation status score, which captures both average methylation level and the pattern of co-methylation. They were able to detect lung and colorectal cancers and to predict their tissue of origin.
1-3
Acton, Richard, James
252d4402-7cd9-4016-a428-4ef3de5fafe2
Bell, Christopher G.
44982df7-0746-4cdb-bed1-0bdfe68f1a64
August 2017
Acton, Richard, James
252d4402-7cd9-4016-a428-4ef3de5fafe2
Bell, Christopher G.
44982df7-0746-4cdb-bed1-0bdfe68f1a64
Acton, Richard, James and Bell, Christopher G.
(2017)
Cancer detection and tissue of origin determination with novel annotation and scoring of cell-free methylated DNA.
AME Medical Journal, 2 (110), .
(doi:10.21037/amj.2017.08.02).
Abstract
In a recent paper, Guo et al. (1) analysed the methylation of DNA fragments circulating in the blood plasma that are released when cells die. Their analysis used a novel approach to annotate DNA methylation and a methylation status score, which captures both average methylation level and the pattern of co-methylation. They were able to detect lung and colorectal cancers and to predict their tissue of origin.
Text
amj-02-110
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Accepted/In Press date: 27 July 2017
e-pub ahead of print date: 15 August 2017
Published date: August 2017
Identifiers
Local EPrints ID: 413775
URI: http://eprints.soton.ac.uk/id/eprint/413775
ISSN: 2520-0518
PURE UUID: daba9a28-44bf-4470-b322-b7c4237ae4e8
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Date deposited: 06 Sep 2017 16:31
Last modified: 15 Mar 2024 15:54
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Author:
Richard, James Acton
Author:
Christopher G. Bell
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