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Cancer detection and tissue of origin determination with novel annotation and scoring of cell-free methylated DNA

Cancer detection and tissue of origin determination with novel annotation and scoring of cell-free methylated DNA
Cancer detection and tissue of origin determination with novel annotation and scoring of cell-free methylated DNA
In a recent paper, Guo et al. (1) analysed the methylation of DNA fragments circulating in the blood plasma that are released when cells die. Their analysis used a novel approach to annotate DNA methylation and a methylation status score, which captures both average methylation level and the pattern of co-methylation. They were able to detect lung and colorectal cancers and to predict their tissue of origin.
2520-0518
1-3
Acton, Richard, James
252d4402-7cd9-4016-a428-4ef3de5fafe2
Bell, Christopher G.
44982df7-0746-4cdb-bed1-0bdfe68f1a64
Acton, Richard, James and Bell, Christopher G. (2017) Cancer detection and tissue of origin determination with novel annotation and scoring of cell-free methylated DNA AME Medical Journal, 2, (110), pp. 1-3. (doi:10.21037/amj.2017.08.02).

Acton, Richard, James and Bell, Christopher G. (2017) Cancer detection and tissue of origin determination with novel annotation and scoring of cell-free methylated DNA AME Medical Journal, 2, (110), pp. 1-3. (doi:10.21037/amj.2017.08.02).

Record type: Editorial

Abstract

In a recent paper, Guo et al. (1) analysed the methylation of DNA fragments circulating in the blood plasma that are released when cells die. Their analysis used a novel approach to annotate DNA methylation and a methylation status score, which captures both average methylation level and the pattern of co-methylation. They were able to detect lung and colorectal cancers and to predict their tissue of origin.

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More information

Accepted/In Press date: 27 July 2017
e-pub ahead of print date: 15 August 2017
Published date: August 2017

Identifiers

Local EPrints ID: 413775
URI: http://eprints.soton.ac.uk/id/eprint/413775
ISSN: 2520-0518
PURE UUID: daba9a28-44bf-4470-b322-b7c4237ae4e8
ORCID for Christopher G. Bell: ORCID iD orcid.org/0000-0003-4601-1242

Catalogue record

Date deposited: 06 Sep 2017 16:31
Last modified: 06 Sep 2017 16:31

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