Mechanical and tribological properties of poly(hydroxyethyl methacrylate) hydrogels as articular cartilage substitutes
Mechanical and tribological properties of poly(hydroxyethyl methacrylate) hydrogels as articular cartilage substitutes
Poly(hydroxyethyl methacrylate) (p(HEMA)) hydrogels have been proposed as promising biomaterials to replace damaged articular cartilage. A major obstacle to their use as replacement bearing tissue is their poor mechanical properties in comparison with healthy articular cartilage. The purpose of this study was to obtain p(HEMA) hydrogels with physicochemical and mechanical properties close to healthy articular cartilage, by introducing a hydrophilic monomer, namely acrylic acid (AA). Formulations of hydrogels with different amounts of hydrophilic monomer (acrylic acid, AA) were synthesized and tested: p(HEMA), p(HEMA-co-5%AA), p(HEMA-co-25%AA). The macro-mechanical tests were reproduced at nanoscale in order to verify if the superficial properties of the hydrogels are similar to the bulk ones.
215-224
Bostan, L.
9b269056-e210-4ab7-815a-f373528dcd66
Trunfio-Sfarghiu, A.-M.
355c5126-1ac4-42b0-bef1-3f4ffccd7d23
Verestiuc, L.
16dd969a-2410-45b9-bf0f-e31324b8dcb6
Popa, M.I.
d3a190fb-46c1-4649-ba4e-2f1caa2bfbd3
Munteanu, F.
921b7645-333b-41b8-92d2-936ce3e2c08b
Rieu, J.-P.
8046e01c-30bc-482d-ae39-245c6ff204d8
Berthier, Y.
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February 2012
Bostan, L.
9b269056-e210-4ab7-815a-f373528dcd66
Trunfio-Sfarghiu, A.-M.
355c5126-1ac4-42b0-bef1-3f4ffccd7d23
Verestiuc, L.
16dd969a-2410-45b9-bf0f-e31324b8dcb6
Popa, M.I.
d3a190fb-46c1-4649-ba4e-2f1caa2bfbd3
Munteanu, F.
921b7645-333b-41b8-92d2-936ce3e2c08b
Rieu, J.-P.
8046e01c-30bc-482d-ae39-245c6ff204d8
Berthier, Y.
3b244fc9-1770-4415-b5bb-e8e087c5588a
Bostan, L., Trunfio-Sfarghiu, A.-M., Verestiuc, L., Popa, M.I., Munteanu, F., Rieu, J.-P. and Berthier, Y.
(2012)
Mechanical and tribological properties of poly(hydroxyethyl methacrylate) hydrogels as articular cartilage substitutes.
Tribology International, 46 (1), .
(doi:10.1016/j.triboint.2011.06.035).
Abstract
Poly(hydroxyethyl methacrylate) (p(HEMA)) hydrogels have been proposed as promising biomaterials to replace damaged articular cartilage. A major obstacle to their use as replacement bearing tissue is their poor mechanical properties in comparison with healthy articular cartilage. The purpose of this study was to obtain p(HEMA) hydrogels with physicochemical and mechanical properties close to healthy articular cartilage, by introducing a hydrophilic monomer, namely acrylic acid (AA). Formulations of hydrogels with different amounts of hydrophilic monomer (acrylic acid, AA) were synthesized and tested: p(HEMA), p(HEMA-co-5%AA), p(HEMA-co-25%AA). The macro-mechanical tests were reproduced at nanoscale in order to verify if the superficial properties of the hydrogels are similar to the bulk ones.
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Accepted/In Press date: 29 June 2011
e-pub ahead of print date: 20 July 2011
Published date: February 2012
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Local EPrints ID: 413827
URI: http://eprints.soton.ac.uk/id/eprint/413827
ISSN: 0301-679X
PURE UUID: 0a23fa8f-7f40-4dad-8b8d-3fbbcad9d376
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Date deposited: 07 Sep 2017 16:31
Last modified: 15 Mar 2024 15:55
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Author:
L. Bostan
Author:
A.-M. Trunfio-Sfarghiu
Author:
L. Verestiuc
Author:
M.I. Popa
Author:
F. Munteanu
Author:
J.-P. Rieu
Author:
Y. Berthier
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