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Hematopoietic stem cell transplantation in T-prolymphocytic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation and the Royal Marsden Consortium

Hematopoietic stem cell transplantation in T-prolymphocytic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation and the Royal Marsden Consortium
Hematopoietic stem cell transplantation in T-prolymphocytic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation and the Royal Marsden Consortium

T-prolymphocytic leukemia (T-PLL) has a very poor prognosis with conventional immunochemotherapy. Incidental reports suggest that allogeneic hematopoietic stem cell transplantation (allo-HSCT) might have a role in this disease. Therefore, the purpose of the present study was to analyze the outcome of transplants for T-PLL registered with the European Group for Blood and Marrow Transplantation database and the Royal Marsden Consortium. Eligible were 41 patients with a median age of 51 (24-71) years; median time from diagnosis to treatment was 12 months, and in complete remission (CR) (11), partial remission (PR) (12), stable or progressive disease (13) and unknown in 5 patients. A total of 13 patients (31%) received reduced-intensity conditioning. Donors were HLA-identical siblings in 21 patients, matched unrelated donors in 20 patients. With a median follow-up of surviving patients of 36 months, 3-year relapse-free survival (RFS) and OS was 19% (95% CI, 6-31%) and 21% (95% CI, 7-34%), respectively. Multivariate analysis identified TBI and a short interval between diagnosis and HSCT as factors associated with favorable RFS. Three-year non relapse mortality and relapse incidence were each 41% with the majority of relapses occurring within the first year. These data indicate that allo-HSCT may provide effective disease control in selected patients with T-PLL.

Adult, Aged, Female, Hematopoietic Stem Cell Transplantation, Humans, Leukemia, Prolymphocytic, T-Cell, Male, Middle Aged, Multivariate Analysis, Remission Induction, Retrospective Studies, Treatment Outcome, Journal Article
0887-6924
972-976
Wiktor-Jedrzejczak, W.
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Dearden, C.
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de Wreede, L.
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van Biezen, A.
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Brinch, L.
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Leblond, V.
bb9b8ab0-c595-4732-b76e-34359bf0b281
Brune, M.
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Volin, L.
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Kazmi, M.
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Nagler, A.
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Schetelig, J.
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de Witte, T.
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Dreger, P.
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Orchard, Kim
794654ab-d6cc-488a-ac11-c9217433c7a2
EBMT Chronic Leukemia Working Party
Wiktor-Jedrzejczak, W.
3f40345d-42e0-4577-91ee-cbf2ecdd6362
Dearden, C.
820743d1-e8d6-4f70-8f75-31415d5f210f
de Wreede, L.
e63ec466-186d-4bc8-adc0-b05431525129
van Biezen, A.
1dae7b9a-38a1-4b43-949e-a63119e5bcef
Brinch, L.
f16a254d-c7f0-4743-926d-e642472c6e07
Leblond, V.
bb9b8ab0-c595-4732-b76e-34359bf0b281
Brune, M.
c82f97b5-8317-40de-97a2-315fdd7b5c0e
Volin, L.
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Kazmi, M.
b3bd9458-f7f7-41bb-a533-9acb60a7506d
Nagler, A.
f65ccdf2-8918-4c30-9211-c0516a3a2c39
Schetelig, J.
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de Witte, T.
5e9f7243-3ef6-4330-8302-fc7f59d4e381
Dreger, P.
c2d629f9-0538-49dd-8a23-dfac013a252d
Orchard, Kim
794654ab-d6cc-488a-ac11-c9217433c7a2

Wiktor-Jedrzejczak, W., Dearden, C., de Wreede, L., van Biezen, A., Brinch, L., Leblond, V., Brune, M., Volin, L., Kazmi, M., Nagler, A., Schetelig, J., de Witte, T., Dreger, P. and Orchard, Kim , EBMT Chronic Leukemia Working Party (2012) Hematopoietic stem cell transplantation in T-prolymphocytic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation and the Royal Marsden Consortium. Leukemia, 26 (5), 972-976. (doi:10.1038/leu.2011.304).

Record type: Article

Abstract

T-prolymphocytic leukemia (T-PLL) has a very poor prognosis with conventional immunochemotherapy. Incidental reports suggest that allogeneic hematopoietic stem cell transplantation (allo-HSCT) might have a role in this disease. Therefore, the purpose of the present study was to analyze the outcome of transplants for T-PLL registered with the European Group for Blood and Marrow Transplantation database and the Royal Marsden Consortium. Eligible were 41 patients with a median age of 51 (24-71) years; median time from diagnosis to treatment was 12 months, and in complete remission (CR) (11), partial remission (PR) (12), stable or progressive disease (13) and unknown in 5 patients. A total of 13 patients (31%) received reduced-intensity conditioning. Donors were HLA-identical siblings in 21 patients, matched unrelated donors in 20 patients. With a median follow-up of surviving patients of 36 months, 3-year relapse-free survival (RFS) and OS was 19% (95% CI, 6-31%) and 21% (95% CI, 7-34%), respectively. Multivariate analysis identified TBI and a short interval between diagnosis and HSCT as factors associated with favorable RFS. Three-year non relapse mortality and relapse incidence were each 41% with the majority of relapses occurring within the first year. These data indicate that allo-HSCT may provide effective disease control in selected patients with T-PLL.

Full text not available from this repository.

More information

Accepted/In Press date: 16 September 2011
e-pub ahead of print date: 25 November 2011
Published date: May 2012
Keywords: Adult, Aged, Female, Hematopoietic Stem Cell Transplantation, Humans, Leukemia, Prolymphocytic, T-Cell, Male, Middle Aged, Multivariate Analysis, Remission Induction, Retrospective Studies, Treatment Outcome, Journal Article

Identifiers

Local EPrints ID: 413856
URI: https://eprints.soton.ac.uk/id/eprint/413856
ISSN: 0887-6924
PURE UUID: 6da7753d-4e3d-48e2-91a2-d7db8dc28e06
ORCID for Kim Orchard: ORCID iD orcid.org/0000-0003-2276-3925

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Date deposited: 07 Sep 2017 16:33
Last modified: 31 Jul 2019 00:44

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Contributors

Author: W. Wiktor-Jedrzejczak
Author: C. Dearden
Author: L. de Wreede
Author: A. van Biezen
Author: L. Brinch
Author: V. Leblond
Author: M. Brune
Author: L. Volin
Author: M. Kazmi
Author: A. Nagler
Author: J. Schetelig
Author: T. de Witte
Author: P. Dreger
Author: Kim Orchard ORCID iD

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