Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study
Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study
Background
Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal.
Methods
We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator.
Results
For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80 mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases.
Conclusions
We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.
450-459
Ong, Jue-Sheng
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Hwang, Liang-Dar
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Cuellar-Partida, Gabriel
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Martin, Nicholas G.
37862efb-17b9-4e80-8cfb-c529355f56e4
Chenevix-Trench, Georgia
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Quinn, Michael C J
d429c1c8-8780-4ef4-837c-16f1e8881b95
Cornelis, Marilyn C
194a43a7-12a5-4bcf-bfcb-48bcb2506a7d
Gharahkhani, Puya
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Webb, Penelope M.
d4eb9e8b-60e1-4388-abd7-7149015eba65
MacGregor, Stuart
c46be706-1eda-4ff5-a7a9-bec56192171e
Eccles, Diana
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
The Ovarian Cancer Association Consortium
Ong, Jue-Sheng
13b0b72c-19f3-409e-9133-9de478ac85c4
Hwang, Liang-Dar
591dac54-1313-4df7-8a3c-f08777a3b255
Cuellar-Partida, Gabriel
455ac480-e5f3-47af-a3f2-260fa94da9ea
Martin, Nicholas G.
37862efb-17b9-4e80-8cfb-c529355f56e4
Chenevix-Trench, Georgia
0e118652-d154-46f7-8b3e-61c5aa346556
Quinn, Michael C J
d429c1c8-8780-4ef4-837c-16f1e8881b95
Cornelis, Marilyn C
194a43a7-12a5-4bcf-bfcb-48bcb2506a7d
Gharahkhani, Puya
3021fb52-5055-450f-bba4-d34492a9533f
Webb, Penelope M.
d4eb9e8b-60e1-4388-abd7-7149015eba65
MacGregor, Stuart
c46be706-1eda-4ff5-a7a9-bec56192171e
Eccles, Diana
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Ong, Jue-Sheng, Hwang, Liang-Dar, Cuellar-Partida, Gabriel, Martin, Nicholas G., Chenevix-Trench, Georgia, Quinn, Michael C J, Cornelis, Marilyn C, Gharahkhani, Puya, Webb, Penelope M. and MacGregor, Stuart
,
The Ovarian Cancer Association Consortium
(2017)
Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.
International Journal of Epidemiology, .
(doi:10.1093/ije/dyx236).
Abstract
Background
Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal.
Methods
We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator.
Results
For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80 mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases.
Conclusions
We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.
Text
IJE_MR_OvCa_coffee_proof
- Accepted Manuscript
More information
Accepted/In Press date: 21 October 2017
e-pub ahead of print date: 25 November 2017
Identifiers
Local EPrints ID: 413993
URI: http://eprints.soton.ac.uk/id/eprint/413993
ISSN: 0300-5771
PURE UUID: 6668dcaa-de3a-48c9-90b5-453e137ebed5
Catalogue record
Date deposited: 12 Sep 2017 16:31
Last modified: 16 Mar 2024 05:42
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Contributors
Author:
Jue-Sheng Ong
Author:
Liang-Dar Hwang
Author:
Gabriel Cuellar-Partida
Author:
Nicholas G. Martin
Author:
Georgia Chenevix-Trench
Author:
Michael C J Quinn
Author:
Marilyn C Cornelis
Author:
Puya Gharahkhani
Author:
Penelope M. Webb
Author:
Stuart MacGregor
Corporate Author: The Ovarian Cancer Association Consortium
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