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[AlCl3(BnMe2-tacn)] – a new metal chelate scaffold for radiofluorination by Cl/F exchange

[AlCl3(BnMe2-tacn)] – a new metal chelate scaffold for radiofluorination by Cl/F exchange
[AlCl3(BnMe2-tacn)] – a new metal chelate scaffold for radiofluorination by Cl/F exchange
Radiofluorination of a 2.63 μM solution (pH 4, NaOAc buffer) of [AlCl3(BnMe2-tacn)] via treatment with 2.99 mol. equiv. of [19F]KF doped with cyclotron-produced [18F]F− target water, with heating to 80–100 °C for 1 h, gives up to 24% 18F incorporation. SPE purification of the [Al19F218F(BnMe2-tacn)] radio-product gives >99% RCP, with excellent stability (>99% RCP after 3 h).
0300-9246
Levason, William
e7f6d7c7-643c-49f5-8b57-0ebbe1bb52cd
Luthra, Sajinder K.
2ad7947e-6a9e-4472-95b4-87274f4d2f54
McRobbie, Graeme
b12f273f-dd78-4ff8-a423-b0b5158091c7
Monzittu, Francesco M.
c0124f10-1f2e-47e5-85f4-138fab36b5d4
Reid, Gillian
37d35b11-40ce-48c5-a68e-f6ce04cd4037
Levason, William
e7f6d7c7-643c-49f5-8b57-0ebbe1bb52cd
Luthra, Sajinder K.
2ad7947e-6a9e-4472-95b4-87274f4d2f54
McRobbie, Graeme
b12f273f-dd78-4ff8-a423-b0b5158091c7
Monzittu, Francesco M.
c0124f10-1f2e-47e5-85f4-138fab36b5d4
Reid, Gillian
37d35b11-40ce-48c5-a68e-f6ce04cd4037

Levason, William, Luthra, Sajinder K., McRobbie, Graeme, Monzittu, Francesco M. and Reid, Gillian (2017) [AlCl3(BnMe2-tacn)] – a new metal chelate scaffold for radiofluorination by Cl/F exchange. Dalton Transactions. (doi:10.1039/C7DT02122D).

Record type: Article

Abstract

Radiofluorination of a 2.63 μM solution (pH 4, NaOAc buffer) of [AlCl3(BnMe2-tacn)] via treatment with 2.99 mol. equiv. of [19F]KF doped with cyclotron-produced [18F]F− target water, with heating to 80–100 °C for 1 h, gives up to 24% 18F incorporation. SPE purification of the [Al19F218F(BnMe2-tacn)] radio-product gives >99% RCP, with excellent stability (>99% RCP after 3 h).

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AlF3 chemistry final accepted version - Accepted Manuscript
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Accepted/In Press date: 9 August 2017
e-pub ahead of print date: 9 August 2017
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Identifiers

Local EPrints ID: 414042
URI: http://eprints.soton.ac.uk/id/eprint/414042
DOI: doi:10.1039/C7DT02122D
ISSN: 0300-9246
PURE UUID: f480b38e-9608-468a-8675-1141c7c7588f
ORCID for William Levason: ORCID iD orcid.org/0000-0003-3540-0971
ORCID for Francesco M. Monzittu: ORCID iD orcid.org/0000-0002-7080-3795
ORCID for Gillian Reid: ORCID iD orcid.org/0000-0001-5349-3468

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Date deposited: 13 Sep 2017 16:31
Last modified: 16 Mar 2024 05:43

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Contributors

Author: William Levason ORCID iD
Author: Sajinder K. Luthra
Author: Graeme McRobbie
Author: Francesco M. Monzittu ORCID iD
Author: Gillian Reid ORCID iD

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