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Altered perceptual binding in Gilles de la Tourette syndrome

Altered perceptual binding in Gilles de la Tourette syndrome
Altered perceptual binding in Gilles de la Tourette syndrome

Gilles de la Tourette syndrome (GTS) is a common multifaceted neuropsychiatric disorder. Research in GTS has traditionally focussed on mechanisms underlying changes in motor processes in these patients. There is, however, growing interest in GTS related sensory phenomena. According to the Theory of Event-coding (TEC), sensory stimuli do not only serve representational functions but also action-related functions. In the current study, we use the TEC framework to examine whether the way perceptual features are processed is altered in GTS. The results show that basic perceptual processes differ between GTS patients and healthy controls which might be central for the understanding of this disorder. Details or features of perceptual objects were less bound in GTS suggesting that perceptual features integration is attenuated in them. Behavioural findings were unrelated to patient characteristics implying that they might represent trait abnormalities. It is possible that altered perceptual processing in GTS is due to a long-range under-connectivity of parietal areas with other brain regions repeatedly been described in these patients.

Journal Article
0010-9452
160-166
Beste, Christian
ba893a9b-c926-4133-afb1-06f33658d96e
Tübing, Jennifer
f8634107-0558-4d50-b913-cbb7565f4d99
Seeliger, Helen
4af3c857-d387-4fdb-b774-242aac79fd17
Bäumer, Tobias
90576a00-054a-4ab7-952e-d50b175f4cec
Brandt, Valerie
e41f5832-70e4-407d-8a15-85b861761656
Stock, Ann-Kathrin
7fc6a3ef-e316-4579-8dd4-5783ec7343a3
Münchau, Alexander
3254c1b7-9fd4-417d-96e2-b7bc1fe3c736
Beste, Christian
ba893a9b-c926-4133-afb1-06f33658d96e
Tübing, Jennifer
f8634107-0558-4d50-b913-cbb7565f4d99
Seeliger, Helen
4af3c857-d387-4fdb-b774-242aac79fd17
Bäumer, Tobias
90576a00-054a-4ab7-952e-d50b175f4cec
Brandt, Valerie
e41f5832-70e4-407d-8a15-85b861761656
Stock, Ann-Kathrin
7fc6a3ef-e316-4579-8dd4-5783ec7343a3
Münchau, Alexander
3254c1b7-9fd4-417d-96e2-b7bc1fe3c736

Beste, Christian, Tübing, Jennifer, Seeliger, Helen, Bäumer, Tobias, Brandt, Valerie, Stock, Ann-Kathrin and Münchau, Alexander (2016) Altered perceptual binding in Gilles de la Tourette syndrome. Cortex, 83, 160-166. (doi:10.1016/j.cortex.2016.07.015).

Record type: Article

Abstract

Gilles de la Tourette syndrome (GTS) is a common multifaceted neuropsychiatric disorder. Research in GTS has traditionally focussed on mechanisms underlying changes in motor processes in these patients. There is, however, growing interest in GTS related sensory phenomena. According to the Theory of Event-coding (TEC), sensory stimuli do not only serve representational functions but also action-related functions. In the current study, we use the TEC framework to examine whether the way perceptual features are processed is altered in GTS. The results show that basic perceptual processes differ between GTS patients and healthy controls which might be central for the understanding of this disorder. Details or features of perceptual objects were less bound in GTS suggesting that perceptual features integration is attenuated in them. Behavioural findings were unrelated to patient characteristics implying that they might represent trait abnormalities. It is possible that altered perceptual processing in GTS is due to a long-range under-connectivity of parietal areas with other brain regions repeatedly been described in these patients.

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Accepted/In Press date: 20 July 2016
e-pub ahead of print date: 30 July 2016
Published date: October 2016
Additional Information: Copyright © 2016 Elsevier Ltd. All rights reserved.
Keywords: Journal Article

Identifiers

Local EPrints ID: 414072
URI: https://eprints.soton.ac.uk/id/eprint/414072
ISSN: 0010-9452
PURE UUID: 3d436032-c898-4df3-bbd0-c9ef01b8fb1b

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Date deposited: 13 Sep 2017 16:31
Last modified: 16 Jul 2019 18:26

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