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Prognostic models for primary mediastinal (thymic) B-cell lymphoma derived from 18-FDG PET/CT quantitative parameters in the International Extranodal Lymphoma Study Group (IELSG) 26 study

Prognostic models for primary mediastinal (thymic) B-cell lymphoma derived from 18-FDG PET/CT quantitative parameters in the International Extranodal Lymphoma Study Group (IELSG) 26 study
Prognostic models for primary mediastinal (thymic) B-cell lymphoma derived from 18-FDG PET/CT quantitative parameters in the International Extranodal Lymphoma Study Group (IELSG) 26 study

The International Extranodal Lymphoma Study Group-26 study evaluated the prognostic role of 18-fluorodeoxyglucose positron-emission tomography (PET) in primary mediastinal large B-cell lymphoma. We assessed quantitative PET parameters at diagnosis and post-treatment in 100 patients. The end-of-therapy total lesion glycolysis (TLG) was the best individual outcome predictor, but the combination of baseline TLG and end-of-therapy visual analysis with Deauville Score (DS) showed a better positive predictive value. A model in which baseline TLG is combined with interim DS might identify patients with shorter progression-free survival. PET metrics combined with interim DS may allow early risk assessment and warrants further studies.

Journal Article
0007-1048
Ceriani, Luca
5767bf0b-1df0-4479-90df-a3e0beb1c8b8
Martelli, Maurizio
32f72970-6db0-45ec-9246-6d074b504192
Conconi, Annarita
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Zinzani, Pier L
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Ferreri, Andrés J M
ce2b2989-3888-49b5-a623-5094175db3d7
Botto, Barbara
b7cc807b-0896-4175-b96d-db92da55017a
Stelitano, Caterina
d20ef370-c8f7-4b5c-8b76-22dda1ba2c15
Gotti, Manuel
4f57bdab-403d-42f2-bdb4-ff10b90f2859
Cabras, Maria G
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Rigacci, Luigi
6597586e-7cbd-4074-b7c9-ef2db97d7844
Giovanella, Luca
f701b100-a7b6-4b35-9bb1-464bcc28a66c
Zucca, Emanuele
40bd5950-d74e-4169-a2ea-0bfc1058058e
Johnson, Peter W.M.
3f6068ce-171e-4c2c-aca9-dc9b6a37413f
Ceriani, Luca
5767bf0b-1df0-4479-90df-a3e0beb1c8b8
Martelli, Maurizio
32f72970-6db0-45ec-9246-6d074b504192
Conconi, Annarita
5f168d0c-4a6b-4dac-9388-97dd2ae83198
Zinzani, Pier L
7cb26036-3e13-4b2d-8ae4-443a7fb4bfc6
Ferreri, Andrés J M
ce2b2989-3888-49b5-a623-5094175db3d7
Botto, Barbara
b7cc807b-0896-4175-b96d-db92da55017a
Stelitano, Caterina
d20ef370-c8f7-4b5c-8b76-22dda1ba2c15
Gotti, Manuel
4f57bdab-403d-42f2-bdb4-ff10b90f2859
Cabras, Maria G
9c24405c-3526-4784-8ac1-aeafd7b24551
Rigacci, Luigi
6597586e-7cbd-4074-b7c9-ef2db97d7844
Giovanella, Luca
f701b100-a7b6-4b35-9bb1-464bcc28a66c
Zucca, Emanuele
40bd5950-d74e-4169-a2ea-0bfc1058058e
Johnson, Peter W.M.
3f6068ce-171e-4c2c-aca9-dc9b6a37413f

Ceriani, Luca, Martelli, Maurizio, Conconi, Annarita, Zinzani, Pier L, Ferreri, Andrés J M, Botto, Barbara, Stelitano, Caterina, Gotti, Manuel, Cabras, Maria G, Rigacci, Luigi, Giovanella, Luca, Zucca, Emanuele and Johnson, Peter W.M. (2017) Prognostic models for primary mediastinal (thymic) B-cell lymphoma derived from 18-FDG PET/CT quantitative parameters in the International Extranodal Lymphoma Study Group (IELSG) 26 study. British Journal of Haematology. (doi:10.1111/bjh.14728).

Record type: Article

Abstract

The International Extranodal Lymphoma Study Group-26 study evaluated the prognostic role of 18-fluorodeoxyglucose positron-emission tomography (PET) in primary mediastinal large B-cell lymphoma. We assessed quantitative PET parameters at diagnosis and post-treatment in 100 patients. The end-of-therapy total lesion glycolysis (TLG) was the best individual outcome predictor, but the combination of baseline TLG and end-of-therapy visual analysis with Deauville Score (DS) showed a better positive predictive value. A model in which baseline TLG is combined with interim DS might identify patients with shorter progression-free survival. PET metrics combined with interim DS may allow early risk assessment and warrants further studies.

Full text not available from this repository.

More information

Accepted/In Press date: 6 March 2017
e-pub ahead of print date: 9 May 2017
Additional Information: © 2017 John Wiley & Sons Ltd.
Keywords: Journal Article

Identifiers

Local EPrints ID: 414117
URI: https://eprints.soton.ac.uk/id/eprint/414117
ISSN: 0007-1048
PURE UUID: 94db1f12-6969-40c7-aad4-f58dbe71286e
ORCID for Peter W.M. Johnson: ORCID iD orcid.org/0000-0003-2306-4974

Catalogue record

Date deposited: 14 Sep 2017 16:32
Last modified: 14 Mar 2019 01:49

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Contributors

Author: Luca Ceriani
Author: Maurizio Martelli
Author: Annarita Conconi
Author: Pier L Zinzani
Author: Andrés J M Ferreri
Author: Barbara Botto
Author: Caterina Stelitano
Author: Manuel Gotti
Author: Maria G Cabras
Author: Luigi Rigacci
Author: Luca Giovanella
Author: Emanuele Zucca

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