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Red blood cell eicosapentaenoic acid inversely relates to MRI-assessed carotid plaque lipid core burden in elders at high cardiovascular risk

Red blood cell eicosapentaenoic acid inversely relates to MRI-assessed carotid plaque lipid core burden in elders at high cardiovascular risk
Red blood cell eicosapentaenoic acid inversely relates to MRI-assessed carotid plaque lipid core burden in elders at high cardiovascular risk
Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 older individuals at high vascular risk grouped into different stages of carotid atherosclerosis severity, including those without ultrasound-detected atheroma plaque (n = 38), with plaques <2.0 mm thick (n = 65), and with plaques ≥2.0 mm (n = 79). The latter were asked to undergo contrast-enhanced 3T magnetic resonance imaging (MRI) and were subsequently grouped into absence (n = 31) or presence (n = 27) of MRI-detectable plaque lipid, a main feature of unstable atheroma plaques. We determined the red blood cell (RBC) proportion of EPA (a valid marker of long-term EPA intake) at enrolment by gas chromatography. In multivariate models, EPA related inversely to MRI-assessed plaque lipid volume, but not to maximum intima-media thickness of internal carotid artery, plaque burden, or MRI-assessed normalized wall index. The inverse association between EPA and plaque lipid content in patients with advanced atherosclerosis supports the notion that this fatty acid might improve cardiovascular health through stabilization of advanced atheroma plaques.
1036
Bargalló, Núria
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Gilabert, Rosa
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Romero-Mamani, Edwin-Saúl
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Cofán, Montserrat
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Calder, Philip
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Fitó, Montserrat
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Corella, Dolores
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Salas-Salvadó, Jordi
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Ruiz-Canela, Miguel
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Estruch, Ramon
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Ros, Emilio
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Sala-Vila, Aleix
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Bargalló, Núria
acf1e2ad-a024-4736-a03c-7e798f11d823
Gilabert, Rosa
674e23f2-692e-4af9-a16e-2806a8d7d832
Romero-Mamani, Edwin-Saúl
c6c0eab8-708b-49e9-8ec2-4f7662beda77
Cofán, Montserrat
4288fedb-9adc-441e-8643-2610e3494c01
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Fitó, Montserrat
ac509ef4-6542-4831-a433-582426a2fd5f
Corella, Dolores
737412df-24d4-456e-8621-98cdb77b22da
Salas-Salvadó, Jordi
0a417b6e-8b24-4d6e-a460-226b5b6b0617
Ruiz-Canela, Miguel
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Estruch, Ramon
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Ros, Emilio
098b17f1-5cb2-4f32-935d-34997b3baede
Sala-Vila, Aleix
a4fd5035-26f9-4f6c-85c4-33278a35a09f

Bargalló, Núria, Gilabert, Rosa, Romero-Mamani, Edwin-Saúl, Cofán, Montserrat, Calder, Philip, Fitó, Montserrat, Corella, Dolores, Salas-Salvadó, Jordi, Ruiz-Canela, Miguel, Estruch, Ramon, Ros, Emilio and Sala-Vila, Aleix (2017) Red blood cell eicosapentaenoic acid inversely relates to MRI-assessed carotid plaque lipid core burden in elders at high cardiovascular risk. Nutrients, 9 (9), 1036. (doi:10.3390/nu9091036).

Record type: Article

Abstract

Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 older individuals at high vascular risk grouped into different stages of carotid atherosclerosis severity, including those without ultrasound-detected atheroma plaque (n = 38), with plaques <2.0 mm thick (n = 65), and with plaques ≥2.0 mm (n = 79). The latter were asked to undergo contrast-enhanced 3T magnetic resonance imaging (MRI) and were subsequently grouped into absence (n = 31) or presence (n = 27) of MRI-detectable plaque lipid, a main feature of unstable atheroma plaques. We determined the red blood cell (RBC) proportion of EPA (a valid marker of long-term EPA intake) at enrolment by gas chromatography. In multivariate models, EPA related inversely to MRI-assessed plaque lipid volume, but not to maximum intima-media thickness of internal carotid artery, plaque burden, or MRI-assessed normalized wall index. The inverse association between EPA and plaque lipid content in patients with advanced atherosclerosis supports the notion that this fatty acid might improve cardiovascular health through stabilization of advanced atheroma plaques.

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Bargallo et al Nutrients_Accepted - Accepted Manuscript
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Accepted/In Press date: 11 September 2017
e-pub ahead of print date: 20 September 2017
Published date: 20 September 2017

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Local EPrints ID: 414254
URI: https://eprints.soton.ac.uk/id/eprint/414254
PURE UUID: 29abd4de-6721-4996-b00f-c5432f7c1c16

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Date deposited: 21 Sep 2017 16:31
Last modified: 18 Jul 2019 11:33

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Contributors

Author: Núria Bargalló
Author: Rosa Gilabert
Author: Edwin-Saúl Romero-Mamani
Author: Montserrat Cofán
Author: Philip Calder
Author: Montserrat Fitó
Author: Dolores Corella
Author: Jordi Salas-Salvadó
Author: Miguel Ruiz-Canela
Author: Ramon Estruch
Author: Emilio Ros
Author: Aleix Sala-Vila

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