Uukuniemi phlebovirus assembly and secretion leave a functional imprint on the virion glycome
Uukuniemi phlebovirus assembly and secretion leave a functional imprint on the virion glycome
Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DCSIGN- dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.
10244-10251
Crispin, Matthew
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Harvey, David J.
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Bitto, David
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Halldorsson, Steinar
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Bonomelli, Camille
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Edgeworth, Matthew
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Scrivens, James H.
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Huiskonen, Juha T.
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Bowden, Thomas A.
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18 June 2014
Crispin, Matthew
cd980957-0943-4b89-b2b2-710f01f33bc9
Harvey, David J.
8bb24417-3852-4b1f-827b-0d5d2c176744
Bitto, David
e21f1990-512d-48b4-8945-09201788bb13
Halldorsson, Steinar
7bf94dad-782a-4f02-907c-06361efb2230
Bonomelli, Camille
51edb32c-85d0-45be-b050-b075cc3f6c28
Edgeworth, Matthew
c5c55ff2-e3a7-4237-baa2-079b0001b688
Scrivens, James H.
14c72a07-84f3-4ae9-b925-c6b594738d62
Huiskonen, Juha T.
75da2956-19f1-427c-8ae6-4b6df68f79c0
Bowden, Thomas A.
4b17a588-ac01-4112-807a-8b99a6c20d0f
Crispin, Matthew, Harvey, David J., Bitto, David, Halldorsson, Steinar, Bonomelli, Camille, Edgeworth, Matthew, Scrivens, James H., Huiskonen, Juha T. and Bowden, Thomas A.
(2014)
Uukuniemi phlebovirus assembly and secretion leave a functional imprint on the virion glycome.
Journal of Virology, 88 (17), .
(doi:10.1128/JVI.01662-14).
Abstract
Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DCSIGN- dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.
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Published date: 18 June 2014
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Local EPrints ID: 414264
URI: http://eprints.soton.ac.uk/id/eprint/414264
ISSN: 0022-538X
PURE UUID: a93a01e6-2b74-4394-b27d-a6f0b666bd70
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Date deposited: 21 Sep 2017 16:31
Last modified: 16 Mar 2024 04:30
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Author:
David J. Harvey
Author:
David Bitto
Author:
Steinar Halldorsson
Author:
Camille Bonomelli
Author:
Matthew Edgeworth
Author:
James H. Scrivens
Author:
Juha T. Huiskonen
Author:
Thomas A. Bowden
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