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Targeting biofilms: Current and prospective therapeutics

Targeting biofilms: Current and prospective therapeutics
Targeting biofilms: Current and prospective therapeutics
Biofilm formation is now recognized as a key virulence factor for a wide range of chronic microbial infections. While it has been well known for decades that bacteria and fungi in biofilms become highly tolerant of antibiotics, the development of effective therapeutics has lagged behind our growing understanding of biofilm biology. The multifactorial nature of biofilm development and drug tolerance imposes significant challenges to conventional antimicrobials, and indicates the need for multi-targeted or combinatorial therapies. In light of the discrepancy between the explosion of papers presenting multitude of methods to control biofilms and the sparsity of biofilm specific treatments available to the clinician, in this review, we focus on current therapeutic strategies and those in development for the treatment of biofilm infections, which target vital structure-function traits and drug tolerance mechanisms, including the extracellular matrix and dormant cells. We emphasize strategies that are supported by in vivo or ex vivo studies, highlight emerging anti-biofilm technologies, and provide a rationale for multi-targeted therapies aimed at disrupting the complex biofilm microenvironment.
1740-1526
740-755
Koo, Hyun
c50a0390-9388-4037-a0ba-117bf1f95982
Allan, Raymond
390a7d0a-38e1-410a-8dfe-c8ef8408f5e1
Howlin, Robert
f3c84990-6196-47d4-ad8a-80954ea46c7f
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Hall-Stoodley, Luanne
94ebdc00-b549-4488-b15f-5310fb965f5b
Koo, Hyun
c50a0390-9388-4037-a0ba-117bf1f95982
Allan, Raymond
390a7d0a-38e1-410a-8dfe-c8ef8408f5e1
Howlin, Robert
f3c84990-6196-47d4-ad8a-80954ea46c7f
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Hall-Stoodley, Luanne
94ebdc00-b549-4488-b15f-5310fb965f5b

Koo, Hyun, Allan, Raymond, Howlin, Robert, Stoodley, Paul and Hall-Stoodley, Luanne (2017) Targeting biofilms: Current and prospective therapeutics. Nature Reviews Microbiology, 15 (12), 740-755. (doi:10.1038/nrmicro.2017.99).

Record type: Article

Abstract

Biofilm formation is now recognized as a key virulence factor for a wide range of chronic microbial infections. While it has been well known for decades that bacteria and fungi in biofilms become highly tolerant of antibiotics, the development of effective therapeutics has lagged behind our growing understanding of biofilm biology. The multifactorial nature of biofilm development and drug tolerance imposes significant challenges to conventional antimicrobials, and indicates the need for multi-targeted or combinatorial therapies. In light of the discrepancy between the explosion of papers presenting multitude of methods to control biofilms and the sparsity of biofilm specific treatments available to the clinician, in this review, we focus on current therapeutic strategies and those in development for the treatment of biofilm infections, which target vital structure-function traits and drug tolerance mechanisms, including the extracellular matrix and dormant cells. We emphasize strategies that are supported by in vivo or ex vivo studies, highlight emerging anti-biofilm technologies, and provide a rationale for multi-targeted therapies aimed at disrupting the complex biofilm microenvironment.

Text
Nature reviews main document clean revised final June 15 2017a - Accepted Manuscript
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Accepted/In Press date: 31 July 2017
e-pub ahead of print date: 25 September 2017

Identifiers

Local EPrints ID: 414344
URI: https://eprints.soton.ac.uk/id/eprint/414344
ISSN: 1740-1526
PURE UUID: ebae5e0a-b560-402e-b8dc-903b12bae66e
ORCID for Paul Stoodley: ORCID iD orcid.org/0000-0001-6069-273X

Catalogue record

Date deposited: 26 Sep 2017 16:31
Last modified: 10 Dec 2019 05:52

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Contributors

Author: Hyun Koo
Author: Raymond Allan
Author: Robert Howlin
Author: Paul Stoodley ORCID iD
Author: Luanne Hall-Stoodley

University divisions

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