Chapter 10 - Antibody glycosylation
Chapter 10 - Antibody glycosylation
The antibody Fc region is posttranslationally modified by N-linked glycosylation. In immunoglobulin G (IgG), the processing of the glycans is restricted by the presence of extensive interaction with the protein surface. The resulting set of antibody glycoforms exhibit a range of effector functions. In this chapter, we outline the impact of glycosylation on the immune function of antibodies and discuss the implications for monoclonal antibody and intravenous immunoglobulin therapies.
Antiboday glycosylation, Antiinflammatory signaling, Degree of flexibility, Glycan biogenesis, Glycan-engineered antibodies, Inflamatory activity, Terminal galactosylation, Terminal mannose, Terminal sialylation
179-194
Yu, Xiaojie
44d52374-eacc-4e23-b7da-c881e6d3a5dd
Baruah, Kavitha
a02f59f3-5e0f-4735-9fdd-639bdbb8f563
Scanlan, Christopher N.
04dd1b57-b6fc-414c-8595-08310dbb3d32
Crispin, Max
cd980957-0943-4b89-b2b2-710f01f33bc9
2013
Yu, Xiaojie
44d52374-eacc-4e23-b7da-c881e6d3a5dd
Baruah, Kavitha
a02f59f3-5e0f-4735-9fdd-639bdbb8f563
Scanlan, Christopher N.
04dd1b57-b6fc-414c-8595-08310dbb3d32
Crispin, Max
cd980957-0943-4b89-b2b2-710f01f33bc9
Yu, Xiaojie, Baruah, Kavitha, Scanlan, Christopher N. and Crispin, Max
(2013)
Chapter 10 - Antibody glycosylation.
In,
Antibody Fc: Linking Adaptive and Innate Immunity.
Elsevier Inc., .
(doi:10.1016/B978-0-12-394802-1.00010-8).
Record type:
Book Section
Abstract
The antibody Fc region is posttranslationally modified by N-linked glycosylation. In immunoglobulin G (IgG), the processing of the glycans is restricted by the presence of extensive interaction with the protein surface. The resulting set of antibody glycoforms exhibit a range of effector functions. In this chapter, we outline the impact of glycosylation on the immune function of antibodies and discuss the implications for monoclonal antibody and intravenous immunoglobulin therapies.
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e-pub ahead of print date: 12 September 2013
Published date: 2013
Keywords:
Antiboday glycosylation, Antiinflammatory signaling, Degree of flexibility, Glycan biogenesis, Glycan-engineered antibodies, Inflamatory activity, Terminal galactosylation, Terminal mannose, Terminal sialylation
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Local EPrints ID: 414416
URI: http://eprints.soton.ac.uk/id/eprint/414416
PURE UUID: 1b817368-f2d1-4162-ab5c-19bab2dbf882
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Date deposited: 28 Sep 2017 16:31
Last modified: 06 Jun 2024 01:59
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Author:
Xiaojie Yu
Author:
Kavitha Baruah
Author:
Christopher N. Scanlan
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