Solution NMR analyses of the C-type carbohydrate recognition domain of DC-SIGNR protein reveal different binding modes for HIV-derived oligosaccharides and smaller glycan fragments
Solution NMR analyses of the C-type carbohydrate recognition domain of DC-SIGNR protein reveal different binding modes for HIV-derived oligosaccharides and smaller glycan fragments
Background: DC-SIGNR, a C-type lectin that promotes infection of pathogens such as HIV, is a promising drug target. Results: The carbohydrate recognition domain of DC-SIGNR is highly dynamic, displaying unique binding modes for individual glycans. Conclusion: More complex, disease-associated glycans have binding modes different from those of smaller glycans previously studied. Significance: Understanding ligand-binding properties and solution dynamics of DC-SIGNR will facilitate therapeutic design.
22745-22757
Probert, Fay
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Whittaker, Sara B M
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Crispin, Max
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Mitchell, Daniel A.
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Dixon, Ann M.
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2 August 2013
Probert, Fay
268eacad-5a47-481f-9423-5633f8524baf
Whittaker, Sara B M
b6a1e8b8-2db2-4452-a8d7-bc5f8a580b5c
Crispin, Max
cd980957-0943-4b89-b2b2-710f01f33bc9
Mitchell, Daniel A.
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Dixon, Ann M.
ca9db90f-7704-420a-87e4-665ec1beab1a
Probert, Fay, Whittaker, Sara B M, Crispin, Max, Mitchell, Daniel A. and Dixon, Ann M.
(2013)
Solution NMR analyses of the C-type carbohydrate recognition domain of DC-SIGNR protein reveal different binding modes for HIV-derived oligosaccharides and smaller glycan fragments.
The Journal of Biological Chemistry, 288 (31), .
(doi:10.1074/jbc.M113.458299).
Abstract
Background: DC-SIGNR, a C-type lectin that promotes infection of pathogens such as HIV, is a promising drug target. Results: The carbohydrate recognition domain of DC-SIGNR is highly dynamic, displaying unique binding modes for individual glycans. Conclusion: More complex, disease-associated glycans have binding modes different from those of smaller glycans previously studied. Significance: Understanding ligand-binding properties and solution dynamics of DC-SIGNR will facilitate therapeutic design.
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e-pub ahead of print date: 20 June 2013
Published date: 2 August 2013
Identifiers
Local EPrints ID: 414421
URI: http://eprints.soton.ac.uk/id/eprint/414421
ISSN: 0021-9258
PURE UUID: 0f512075-9ddb-41dd-844b-6581d0a7ced5
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Date deposited: 28 Sep 2017 16:31
Last modified: 16 Mar 2024 04:30
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Contributors
Author:
Fay Probert
Author:
Sara B M Whittaker
Author:
Daniel A. Mitchell
Author:
Ann M. Dixon
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