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Unusual molecular architecture of the Machupo virus attachment glycoprotein

Unusual molecular architecture of the Machupo virus attachment glycoprotein
Unusual molecular architecture of the Machupo virus attachment glycoprotein

New World arenaviruses, which cause severe hemorrhagic fever, rely upon their envelope glycoproteins for attachment and fusion into their host cell. Here we present the crystal structure of the Machupo virus GP1 attachment glycoprotein, which is responsible for high-affinity binding at the cell surface to the transferrin receptor. This first structure of an arenavirus glycoprotein shows that GP1 consists of a novel α/β fold. This provides a blueprint of the New World arenavirus attachment glycoproteins and reveals a new architecture of viral attachment, using a protein fold of unknown origins.

0022-538X
8259-8265
Bowden, Thomas A.
4b17a588-ac01-4112-807a-8b99a6c20d0f
Crispin, Max
cd980957-0943-4b89-b2b2-710f01f33bc9
Graham, Stephen C.
c04432a3-9ac7-4c3d-8ab3-f08eaa911d80
Harvey, David J.
8bb24417-3852-4b1f-827b-0d5d2c176744
Grimes, Jonathan M.
f6822086-e726-4829-8c75-823e581bcb76
Yvonne Jones, E.
6b9004c9-137b-4f43-8a14-c7c83bcaa4be
Stuart, David I.
2751c230-9d4c-4981-aeb7-cafb51ed749d
Bowden, Thomas A.
4b17a588-ac01-4112-807a-8b99a6c20d0f
Crispin, Max
cd980957-0943-4b89-b2b2-710f01f33bc9
Graham, Stephen C.
c04432a3-9ac7-4c3d-8ab3-f08eaa911d80
Harvey, David J.
8bb24417-3852-4b1f-827b-0d5d2c176744
Grimes, Jonathan M.
f6822086-e726-4829-8c75-823e581bcb76
Yvonne Jones, E.
6b9004c9-137b-4f43-8a14-c7c83bcaa4be
Stuart, David I.
2751c230-9d4c-4981-aeb7-cafb51ed749d

Bowden, Thomas A., Crispin, Max, Graham, Stephen C., Harvey, David J., Grimes, Jonathan M., Yvonne Jones, E. and Stuart, David I. (2009) Unusual molecular architecture of the Machupo virus attachment glycoprotein. Journal of Virology, 83 (16), 8259-8265. (doi:10.1128/JVI.00761-09).

Record type: Article

Abstract

New World arenaviruses, which cause severe hemorrhagic fever, rely upon their envelope glycoproteins for attachment and fusion into their host cell. Here we present the crystal structure of the Machupo virus GP1 attachment glycoprotein, which is responsible for high-affinity binding at the cell surface to the transferrin receptor. This first structure of an arenavirus glycoprotein shows that GP1 consists of a novel α/β fold. This provides a blueprint of the New World arenavirus attachment glycoproteins and reveals a new architecture of viral attachment, using a protein fold of unknown origins.

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Published date: August 2009

Identifiers

Local EPrints ID: 414587
URI: https://eprints.soton.ac.uk/id/eprint/414587
ISSN: 0022-538X
PURE UUID: 6cad2c67-0ac4-4a5b-b310-51f5814f2221
ORCID for Max Crispin: ORCID iD orcid.org/0000-0002-1072-2694

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Date deposited: 04 Oct 2017 16:30
Last modified: 05 Nov 2019 01:27

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