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Individual, partner, and couple predictors of HIV infection among pregnant women in Malawi: a case-control study

Individual, partner, and couple predictors of HIV infection among pregnant women in Malawi: a case-control study
Individual, partner, and couple predictors of HIV infection among pregnant women in Malawi: a case-control study
We aimed to understand drivers of HIV-infection in pregnant women in Malawi. The study was conducted in antenatal and labor and delivery wards. HIV-infected women and their partners (cases) were frequency matched in a 1:2 ratio based on age and screening location to HIV-uninfected women and their partners (controls) in a prevalent case-control study. Characteristics associated with female HIV infection were assessed using logistic regression modeling. At screening, HIV-infected women were more likely to have partners outside Lilongwe than HIV-uninfected women (24% versus 0%, p<0.0001). Case females were more likely to have HIV-infected study partners than control females (75% versus 4%, p<0.0001). The odds of female HIV-infection were higher if either couple member reported >2 lifetime marriages (OR=9.0, CI=2.6-30.9) or >3 lifetime partners (OR=18.0, CI=3.1-103.6) and lower if either reported past couple HIV testing and counseling (OR=0.1, CI=0.04-0.3). Targeting women with migrating partners, promoting couple HIV testing and counseling, and limiting partners could slow HIV transmission
1090-7165
Rosenberg, Nora
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Graybill, Lauren A
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Wesevich, Austin
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Mcgrath, Nuala
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Maman, Suzanne
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Golin, Carol E
d36e93ad-1974-468a-9408-253732a4551e
Chimndozi, Limbikani
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Tsidya, Mercy
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Hoffman, Irving F
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Hosseinipour, Mina C.
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Miller, William C.
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Rosenberg, Nora
876a5d7d-2a3d-4324-b0ba-f7f74e048a5d
Graybill, Lauren A
28ba762b-91bc-491f-88b2-195089ea03f1
Wesevich, Austin
7b3ddfa8-1c84-4d29-a15e-ec44847eaa18
Mcgrath, Nuala
b75c0232-24ec-443f-93a9-69e9e12dc961
Maman, Suzanne
2f864087-d6bd-474a-952b-1c641627661a
Golin, Carol E
d36e93ad-1974-468a-9408-253732a4551e
Chimndozi, Limbikani
2cc87d24-543f-40d6-9d37-47cd619e2b7f
Tsidya, Mercy
bb5f846e-4637-4d78-b97e-69e8d81330e9
Hoffman, Irving F
565ea56e-e0e6-4234-956e-8a5a6f14aeb8
Hosseinipour, Mina C.
02e73573-3695-4457-a0d3-ef2d88e9e108
Miller, William C.
7b8799a7-7671-4bde-a488-700d33f31fbc

Rosenberg, Nora, Graybill, Lauren A, Wesevich, Austin, Mcgrath, Nuala, Maman, Suzanne, Golin, Carol E, Chimndozi, Limbikani, Tsidya, Mercy, Hoffman, Irving F, Hosseinipour, Mina C. and Miller, William C. (2017) Individual, partner, and couple predictors of HIV infection among pregnant women in Malawi: a case-control study. AIDS and Behavior. (doi:10.1007/s10461-017-1947-7).

Record type: Article

Abstract

We aimed to understand drivers of HIV-infection in pregnant women in Malawi. The study was conducted in antenatal and labor and delivery wards. HIV-infected women and their partners (cases) were frequency matched in a 1:2 ratio based on age and screening location to HIV-uninfected women and their partners (controls) in a prevalent case-control study. Characteristics associated with female HIV infection were assessed using logistic regression modeling. At screening, HIV-infected women were more likely to have partners outside Lilongwe than HIV-uninfected women (24% versus 0%, p<0.0001). Case females were more likely to have HIV-infected study partners than control females (75% versus 4%, p<0.0001). The odds of female HIV-infection were higher if either couple member reported >2 lifetime marriages (OR=9.0, CI=2.6-30.9) or >3 lifetime partners (OR=18.0, CI=3.1-103.6) and lower if either reported past couple HIV testing and counseling (OR=0.1, CI=0.04-0.3). Targeting women with migrating partners, promoting couple HIV testing and counseling, and limiting partners could slow HIV transmission

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K99.risk.submission.5oct2017 - Accepted Manuscript
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Accepted/In Press date: 26 September 2017
e-pub ahead of print date: 30 October 2017

Identifiers

Local EPrints ID: 415014
URI: http://eprints.soton.ac.uk/id/eprint/415014
ISSN: 1090-7165
PURE UUID: 6d011a9f-26ed-476d-b8b1-7cf6646e9e6f
ORCID for Nuala Mcgrath: ORCID iD orcid.org/0000-0002-1039-0159

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Date deposited: 20 Oct 2017 16:31
Last modified: 16 Mar 2024 05:49

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Contributors

Author: Nora Rosenberg
Author: Lauren A Graybill
Author: Austin Wesevich
Author: Nuala Mcgrath ORCID iD
Author: Suzanne Maman
Author: Carol E Golin
Author: Limbikani Chimndozi
Author: Mercy Tsidya
Author: Irving F Hoffman
Author: Mina C. Hosseinipour
Author: William C. Miller

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