The University of Southampton
University of Southampton Institutional Repository

Animal models of cerebral amyloid angiopathy

Animal models of cerebral amyloid angiopathy
Animal models of cerebral amyloid angiopathy
Cerebral amyloid angiopathy (CAA), due to vascular amyloid β (Aβ) deposition, is a risk factor for intracerebral haemorrhage and dementia. CAA can occur in sporadic or rare hereditary forms, and is almost invariably associated with Alzheimer’s disease (AD). Experimental (animal) models are of great interest in studying mechanisms and potential treatments for CAA. Naturally occurring animal models of CAA exist, including cats, dogs and non-human primates, which can be used for longitudinal studies. However, due to ethical considerations and low throughput of these models, other animal models are more favourable for research. In the past two decades, a variety of transgenic mouse models expressing the human Aβ precursor protein (APP) has been developed. Many of these mouse models develop CAA in addition to senile plaques, whereas some of these models were generated specifically to study CAA. In addition, other animal models make use of a second stimulus, such as hypoperfusion or hyperhomocysteinemia (HHcy), to accelerate CAA. In this manuscript, we provide a comprehensive review of existing animal models for CAA, which can aid in understanding the pathophysiology of CAA and explore the response to potential therapies.
0143-5221
2469-2488
Jäkel, Lieke
c502334c-8521-4a72-a75e-8ee4105e9ee7
Van Nostrand, William E.
ad2c1019-ba13-4a03-8de1-54289cc1ba81
Nicoll, James A.R.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Werring, David J.
0caabc8a-8597-4f08-9189-e8a6e6a213a6
Verbeek, Marcel M.
c21991ca-081f-4249-9c88-ba1a94b58b3f
Jäkel, Lieke
c502334c-8521-4a72-a75e-8ee4105e9ee7
Van Nostrand, William E.
ad2c1019-ba13-4a03-8de1-54289cc1ba81
Nicoll, James A.R.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Werring, David J.
0caabc8a-8597-4f08-9189-e8a6e6a213a6
Verbeek, Marcel M.
c21991ca-081f-4249-9c88-ba1a94b58b3f

Jäkel, Lieke, Van Nostrand, William E., Nicoll, James A.R., Werring, David J. and Verbeek, Marcel M. (2017) Animal models of cerebral amyloid angiopathy. Clinical Science, 131 (19), 2469-2488. (doi:10.1042/CS20170033).

Record type: Article

Abstract

Cerebral amyloid angiopathy (CAA), due to vascular amyloid β (Aβ) deposition, is a risk factor for intracerebral haemorrhage and dementia. CAA can occur in sporadic or rare hereditary forms, and is almost invariably associated with Alzheimer’s disease (AD). Experimental (animal) models are of great interest in studying mechanisms and potential treatments for CAA. Naturally occurring animal models of CAA exist, including cats, dogs and non-human primates, which can be used for longitudinal studies. However, due to ethical considerations and low throughput of these models, other animal models are more favourable for research. In the past two decades, a variety of transgenic mouse models expressing the human Aβ precursor protein (APP) has been developed. Many of these mouse models develop CAA in addition to senile plaques, whereas some of these models were generated specifically to study CAA. In addition, other animal models make use of a second stimulus, such as hypoperfusion or hyperhomocysteinemia (HHcy), to accelerate CAA. In this manuscript, we provide a comprehensive review of existing animal models for CAA, which can aid in understanding the pathophysiology of CAA and explore the response to potential therapies.

Text
Jakel et al 2017 - Accepted Manuscript
Download (2MB)

More information

Accepted/In Press date: 29 August 2017
e-pub ahead of print date: 28 September 2017
Published date: 15 October 2017

Identifiers

Local EPrints ID: 415019
URI: https://eprints.soton.ac.uk/id/eprint/415019
ISSN: 0143-5221
PURE UUID: 71cb5e3c-d341-4a18-890b-bb705392832d
ORCID for James A.R. Nicoll: ORCID iD orcid.org/0000-0002-9444-7246

Catalogue record

Date deposited: 20 Oct 2017 16:31
Last modified: 10 Dec 2019 05:46

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×