Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine
Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine
In this review, we focus on the secreted form of nicotinamide phosphoribosyltransferase (NAMPT); extracellular NAMPT (eNAMPT), also known as pre-B cell colony-enhancing factor or visfatin. Although intracellular NAMPT is a key enzyme in controlling NAD metabolism, eNAMPT has been reported to function as a cytokine, with many roles in physiology and pathology. Circulating eNAMPT has been associated with several metabolic and inflammatory disorders, including cancer. Because cytokines produced in the tumour micro-environment play an important role in cancer pathogenesis, in part by reprogramming cellular metabolism, future improvements in cancer immunotherapy will require a better understanding of the crosstalk between cytokine action and tumour biology. In this review, the knowledge of eNAMPT in cancer will be discussed, focusing on its immunometabolic function as a metabokine, its secretion, its mechanism of action and possible roles in the cancer micro-environment.
2182-2194
Grolla, Ambra A.
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Travelli, Cristina
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Genazzani, Armando A.
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Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
July 2016
Grolla, Ambra A.
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Travelli, Cristina
06bd23d9-647b-4884-b9bb-6718869d5036
Genazzani, Armando A.
d2f71af6-cfc3-4177-9cfc-bb4d79949639
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Grolla, Ambra A., Travelli, Cristina, Genazzani, Armando A. and Sethi, Jaswinder K.
(2016)
Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine.
British Journal of Pharmacology, 173 (14), .
(doi:10.1111/bph.13505).
Abstract
In this review, we focus on the secreted form of nicotinamide phosphoribosyltransferase (NAMPT); extracellular NAMPT (eNAMPT), also known as pre-B cell colony-enhancing factor or visfatin. Although intracellular NAMPT is a key enzyme in controlling NAD metabolism, eNAMPT has been reported to function as a cytokine, with many roles in physiology and pathology. Circulating eNAMPT has been associated with several metabolic and inflammatory disorders, including cancer. Because cytokines produced in the tumour micro-environment play an important role in cancer pathogenesis, in part by reprogramming cellular metabolism, future improvements in cancer immunotherapy will require a better understanding of the crosstalk between cytokine action and tumour biology. In this review, the knowledge of eNAMPT in cancer will be discussed, focusing on its immunometabolic function as a metabokine, its secretion, its mechanism of action and possible roles in the cancer micro-environment.
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Grolla_et_al-2016-British_Journal_of_Pharmacology
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Accepted/In Press date: 15 April 2016
e-pub ahead of print date: 2 June 2016
Published date: July 2016
Identifiers
Local EPrints ID: 415250
URI: http://eprints.soton.ac.uk/id/eprint/415250
ISSN: 0007-1188
PURE UUID: e27d6682-9706-495d-a8d4-fc334af99d11
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Date deposited: 06 Nov 2017 17:30
Last modified: 16 Mar 2024 04:31
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Author:
Ambra A. Grolla
Author:
Cristina Travelli
Author:
Armando A. Genazzani
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