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Diagnosis of dementia by machine learning methods in Epidemiological studies: a pilot exploratory study from South India

Diagnosis of dementia by machine learning methods in Epidemiological studies: a pilot exploratory study from South India
Diagnosis of dementia by machine learning methods in Epidemiological studies: a pilot exploratory study from South India
Background:

There are limited data on the use of artificial intelligence methods for the diagnosis of dementia in epidemiological studies in low- and middle-income country (LMIC) settings. A culture and education fair battery of cognitive tests was developed and validated for population based studies in low- and middle-income countries including India by the 10/66 Dementia Research Group.

Aims:

We explored the machine learning methods based on the 10/66 battery of cognitive tests for the diagnosis of dementia based in a birth cohort study in South India.

Methods:

The data sets for 466 men and women for this study were obtained from the on-going Mysore Studies of Natal effect of Health and Ageing (MYNAH), in south India. The data sets included: demographics, performance on the 10/66 cognitive function tests, the 10/66 diagnosis of mental disorders and population based normative data for the 10/66 battery of cognitive function tests. Diagnosis of dementia from the rule based approach was compared against the 10/66 diagnosis of dementia. We have applied machine learning techniques to identify minimal number of the 10/66 cognitive function tests required for diagnosing dementia and derived an algorithm to improve the accuracy of dementia diagnosis.

Results:

Of 466 subjects, 27 had 10/66 diagnosis of dementia, 19 of whom were correctly identified as having dementia by Jrip classification with 100% accuracy.

Conclusions:

This pilot exploratory study indicates that machine learning methods can help identify community dwelling older adults with 10/66 criterion diagnosis of dementia with good accuracy in a LMIC setting such as India. This should reduce the duration of the diagnostic assessment and make the process easier and quicker for clinicians, patients and will be useful for ‘case’ ascertainment in population based epidemiological studies.
0933-7954
Bhagyashree, Sheshadri Iyengar Raghavan
5dfffbcc-e175-48d4-a904-b6ff29d10b07
Nagaraj, Kiran
cdfac14e-6c86-4648-b2a2-90f18d84ff69
Prince, Martin
ff242776-7147-4b2a-96ac-05f2c8f008e3
Fall, Caroline H.D.
7171a105-34f5-4131-89d7-1aa639893b18
Krishna, Murali
323774b9-e195-4608-8aa2-adb3d16f4637
Bhagyashree, Sheshadri Iyengar Raghavan
5dfffbcc-e175-48d4-a904-b6ff29d10b07
Nagaraj, Kiran
cdfac14e-6c86-4648-b2a2-90f18d84ff69
Prince, Martin
ff242776-7147-4b2a-96ac-05f2c8f008e3
Fall, Caroline H.D.
7171a105-34f5-4131-89d7-1aa639893b18
Krishna, Murali
323774b9-e195-4608-8aa2-adb3d16f4637

Bhagyashree, Sheshadri Iyengar Raghavan, Nagaraj, Kiran, Prince, Martin, Fall, Caroline H.D. and Krishna, Murali (2017) Diagnosis of dementia by machine learning methods in Epidemiological studies: a pilot exploratory study from South India. Social Psychiatry and Psychiatric Epidemiology. (doi:10.1007/s00127-017-1410-0).

Record type: Article

Abstract

Background:

There are limited data on the use of artificial intelligence methods for the diagnosis of dementia in epidemiological studies in low- and middle-income country (LMIC) settings. A culture and education fair battery of cognitive tests was developed and validated for population based studies in low- and middle-income countries including India by the 10/66 Dementia Research Group.

Aims:

We explored the machine learning methods based on the 10/66 battery of cognitive tests for the diagnosis of dementia based in a birth cohort study in South India.

Methods:

The data sets for 466 men and women for this study were obtained from the on-going Mysore Studies of Natal effect of Health and Ageing (MYNAH), in south India. The data sets included: demographics, performance on the 10/66 cognitive function tests, the 10/66 diagnosis of mental disorders and population based normative data for the 10/66 battery of cognitive function tests. Diagnosis of dementia from the rule based approach was compared against the 10/66 diagnosis of dementia. We have applied machine learning techniques to identify minimal number of the 10/66 cognitive function tests required for diagnosing dementia and derived an algorithm to improve the accuracy of dementia diagnosis.

Results:

Of 466 subjects, 27 had 10/66 diagnosis of dementia, 19 of whom were correctly identified as having dementia by Jrip classification with 100% accuracy.

Conclusions:

This pilot exploratory study indicates that machine learning methods can help identify community dwelling older adults with 10/66 criterion diagnosis of dementia with good accuracy in a LMIC setting such as India. This should reduce the duration of the diagnostic assessment and make the process easier and quicker for clinicians, patients and will be useful for ‘case’ ascertainment in population based epidemiological studies.

Full text not available from this repository.

More information

Accepted/In Press date: 15 June 2017
e-pub ahead of print date: 11 July 2017

Identifiers

Local EPrints ID: 415286
URI: https://eprints.soton.ac.uk/id/eprint/415286
ISSN: 0933-7954
PURE UUID: 94e9c989-bbac-4bea-912c-7fd2999d17b6

Catalogue record

Date deposited: 06 Nov 2017 17:30
Last modified: 13 Mar 2019 19:31

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