The University of Southampton
University of Southampton Institutional Repository

TNF-α and adipocyte biology

TNF-α and adipocyte biology
TNF-α and adipocyte biology

Dyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic conditions (such as cancer and sepsis) and with pathological states of nutritional overload (such as obesity-related type 2 diabetes). Two common features of these metabolic disorders are adipose tissue dysfunction and elevated levels of tumour necrosis factor-alpha (TNF-α). Herein, we review the multiple actions of this pro-inflammatory adipokine on adipose tissue biology. These include inhibition of carbohydrate metabolism, lipogenesis, adipogenesis and thermogenesis and stimulation of lipolysis. TNF-α can also impact the endocrine functions of adipose tissue. Taken together, TNF-α contributes to metabolic dysregulation by impairing both adipose tissue function and its ability to store excess fuel. The molecular mechanisms that underlie these actions are discussed.

Antiadipogenesis, Dyslipidemia, Insulin resistance, Lipid metabolism, Metabolic syndrome, Obesity, TNF signalling, Type 2 diabetes
0014-5793
117-131
Cawthorn, William P.
3eadef28-0866-4a73-81e7-f08db6f7d731
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Cawthorn, William P.
3eadef28-0866-4a73-81e7-f08db6f7d731
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85

Cawthorn, William P. and Sethi, Jaswinder K. (2008) TNF-α and adipocyte biology. FEBS Letters, 582 (1), 117-131. (doi:10.1016/j.febslet.2007.11.051).

Record type: Review

Abstract

Dyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic conditions (such as cancer and sepsis) and with pathological states of nutritional overload (such as obesity-related type 2 diabetes). Two common features of these metabolic disorders are adipose tissue dysfunction and elevated levels of tumour necrosis factor-alpha (TNF-α). Herein, we review the multiple actions of this pro-inflammatory adipokine on adipose tissue biology. These include inhibition of carbohydrate metabolism, lipogenesis, adipogenesis and thermogenesis and stimulation of lipolysis. TNF-α can also impact the endocrine functions of adipose tissue. Taken together, TNF-α contributes to metabolic dysregulation by impairing both adipose tissue function and its ability to store excess fuel. The molecular mechanisms that underlie these actions are discussed.

Full text not available from this repository.

More information

Accepted/In Press date: 6 November 2007
e-pub ahead of print date: 26 November 2007
Published date: 9 January 2008
Keywords: Antiadipogenesis, Dyslipidemia, Insulin resistance, Lipid metabolism, Metabolic syndrome, Obesity, TNF signalling, Type 2 diabetes

Identifiers

Local EPrints ID: 415306
URI: https://eprints.soton.ac.uk/id/eprint/415306
ISSN: 0014-5793
PURE UUID: 2e86366b-ad50-4ccb-9571-d134caded4c1
ORCID for Jaswinder K. Sethi: ORCID iD orcid.org/0000-0003-4157-0475

Catalogue record

Date deposited: 07 Nov 2017 17:30
Last modified: 19 Nov 2019 01:26

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×