TNF-α and adipocyte biology
TNF-α and adipocyte biology
Dyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic conditions (such as cancer and sepsis) and with pathological states of nutritional overload (such as obesity-related type 2 diabetes). Two common features of these metabolic disorders are adipose tissue dysfunction and elevated levels of tumour necrosis factor-alpha (TNF-α). Herein, we review the multiple actions of this pro-inflammatory adipokine on adipose tissue biology. These include inhibition of carbohydrate metabolism, lipogenesis, adipogenesis and thermogenesis and stimulation of lipolysis. TNF-α can also impact the endocrine functions of adipose tissue. Taken together, TNF-α contributes to metabolic dysregulation by impairing both adipose tissue function and its ability to store excess fuel. The molecular mechanisms that underlie these actions are discussed.
Antiadipogenesis, Dyslipidemia, Insulin resistance, Lipid metabolism, Metabolic syndrome, Obesity, TNF signalling, Type 2 diabetes
117-131
Cawthorn, William P.
3eadef28-0866-4a73-81e7-f08db6f7d731
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
9 January 2008
Cawthorn, William P.
3eadef28-0866-4a73-81e7-f08db6f7d731
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Abstract
Dyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic conditions (such as cancer and sepsis) and with pathological states of nutritional overload (such as obesity-related type 2 diabetes). Two common features of these metabolic disorders are adipose tissue dysfunction and elevated levels of tumour necrosis factor-alpha (TNF-α). Herein, we review the multiple actions of this pro-inflammatory adipokine on adipose tissue biology. These include inhibition of carbohydrate metabolism, lipogenesis, adipogenesis and thermogenesis and stimulation of lipolysis. TNF-α can also impact the endocrine functions of adipose tissue. Taken together, TNF-α contributes to metabolic dysregulation by impairing both adipose tissue function and its ability to store excess fuel. The molecular mechanisms that underlie these actions are discussed.
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Accepted/In Press date: 6 November 2007
e-pub ahead of print date: 26 November 2007
Published date: 9 January 2008
Keywords:
Antiadipogenesis, Dyslipidemia, Insulin resistance, Lipid metabolism, Metabolic syndrome, Obesity, TNF signalling, Type 2 diabetes
Identifiers
Local EPrints ID: 415306
URI: http://eprints.soton.ac.uk/id/eprint/415306
ISSN: 0014-5793
PURE UUID: 2e86366b-ad50-4ccb-9571-d134caded4c1
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Date deposited: 07 Nov 2017 17:30
Last modified: 16 Mar 2024 04:31
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Author:
William P. Cawthorn
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