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Adipogenesis and WNT signalling

Adipogenesis and WNT signalling
Adipogenesis and WNT signalling

An inability of adipose tissue to expand consequent to exhausted capacity to recruit new adipocytes might underlie the association between obesity and insulin resistance. Adipocytes arise from mesenchymal precursors whose commitment and differentiation along the adipocytic lineage is tightly regulated. These regulatory factors mediate cross-talk between adipose cells, ensuring that adipocyte growth and differentiation are coupled to energy storage demands. The WNT family of autocrine and paracrine growth factors regulates adult tissue maintenance and remodelling and, consequently, is well suited to mediate adipose cell communication. Indeed, several recent reports, summarized in this review, implicate WNT signalling in regulating adipogenesis. Manipulating the WNT pathway to alter adipose cellular makeup, therefore, constitutes an attractive drug-development target to combat obesity-associated metabolic complications.

1043-2760
16-24
Christodoulides, Constantinos
f5ad503b-bd23-4f57-8e5f-4a7d9ab6c7e5
Lagathu, Claire
a5c17148-6f7d-4062-a44f-284aa1a923a1
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Vidal-Puig, Antonio
7d46d380-1b9d-40cb-90a3-72679e143036
Christodoulides, Constantinos
f5ad503b-bd23-4f57-8e5f-4a7d9ab6c7e5
Lagathu, Claire
a5c17148-6f7d-4062-a44f-284aa1a923a1
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Vidal-Puig, Antonio
7d46d380-1b9d-40cb-90a3-72679e143036

Christodoulides, Constantinos, Lagathu, Claire, Sethi, Jaswinder K. and Vidal-Puig, Antonio (2009) Adipogenesis and WNT signalling. Trends in Endocrinology and Metabolism, 20 (1), 16-24. (doi:10.1016/j.tem.2008.09.002).

Record type: Review

Abstract

An inability of adipose tissue to expand consequent to exhausted capacity to recruit new adipocytes might underlie the association between obesity and insulin resistance. Adipocytes arise from mesenchymal precursors whose commitment and differentiation along the adipocytic lineage is tightly regulated. These regulatory factors mediate cross-talk between adipose cells, ensuring that adipocyte growth and differentiation are coupled to energy storage demands. The WNT family of autocrine and paracrine growth factors regulates adult tissue maintenance and remodelling and, consequently, is well suited to mediate adipose cell communication. Indeed, several recent reports, summarized in this review, implicate WNT signalling in regulating adipogenesis. Manipulating the WNT pathway to alter adipose cellular makeup, therefore, constitutes an attractive drug-development target to combat obesity-associated metabolic complications.

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More information

e-pub ahead of print date: 13 November 2008
Published date: January 2009

Identifiers

Local EPrints ID: 415310
URI: https://eprints.soton.ac.uk/id/eprint/415310
ISSN: 1043-2760
PURE UUID: 634fc4d9-ca83-4dde-b616-7c330d867058
ORCID for Jaswinder K. Sethi: ORCID iD orcid.org/0000-0003-4157-0475

Catalogue record

Date deposited: 07 Nov 2017 17:30
Last modified: 12 Nov 2019 01:26

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