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Synthesis of 7-deaza-8-bromo cyclic adenosine 5′-diphosphate ribose: The first hydrolysis resistant antagonist at the cADPR receptor

Synthesis of 7-deaza-8-bromo cyclic adenosine 5′-diphosphate ribose: The first hydrolysis resistant antagonist at the cADPR receptor
Synthesis of 7-deaza-8-bromo cyclic adenosine 5′-diphosphate ribose: The first hydrolysis resistant antagonist at the cADPR receptor

7-Deaza-8-bromo cyclic adenosine 5′-diphosphate ribose is synthesised from 7-deazaadenosine via 7-deaza-8-bromo nicotinamide adenine dinucleotide; it is both a more potent antagonist than the 8-bromo derivative and has the advantage of chemical and enzymatic hydrolytic stability.

1359-7345
695-696
Bailey, Victoria C.
8c5211f0-cc09-430c-90f0-e58622cf0881
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Galione, Antony
cb0ece65-6c8a-4c54-9f12-7cd954e0955b
Potter, Barry V.L.
a2fd9ce8-0e83-4aee-a362-25a750c5c0c8
Bailey, Victoria C.
8c5211f0-cc09-430c-90f0-e58622cf0881
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Galione, Antony
cb0ece65-6c8a-4c54-9f12-7cd954e0955b
Potter, Barry V.L.
a2fd9ce8-0e83-4aee-a362-25a750c5c0c8

Bailey, Victoria C., Sethi, Jaswinder K., Galione, Antony and Potter, Barry V.L. (1997) Synthesis of 7-deaza-8-bromo cyclic adenosine 5′-diphosphate ribose: The first hydrolysis resistant antagonist at the cADPR receptor. Chemical Communications, (7), 695-696. (doi:10.1039/A700336F).

Record type: Article

Abstract

7-Deaza-8-bromo cyclic adenosine 5′-diphosphate ribose is synthesised from 7-deazaadenosine via 7-deaza-8-bromo nicotinamide adenine dinucleotide; it is both a more potent antagonist than the 8-bromo derivative and has the advantage of chemical and enzymatic hydrolytic stability.

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Published date: 1997
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Local EPrints ID: 415401
URI: http://eprints.soton.ac.uk/id/eprint/415401
DOI: doi:10.1039/A700336F
ISSN: 1359-7345
PURE UUID: 4a22ff87-0158-4d2e-9fcf-ecfa125afe58
ORCID for Jaswinder K. Sethi: ORCID iD orcid.org/0000-0003-4157-0475

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Date deposited: 09 Nov 2017 17:30
Last modified: 06 Jun 2024 01:59

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Contributors

Author: Victoria C. Bailey
Author: Jaswinder K. Sethi ORCID iD
Author: Antony Galione
Author: Barry V.L. Potter

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