The role of TNFα in adipocyte metabolism
The role of TNFα in adipocyte metabolism
Tumor necrosis factor-alpha (TNFα) is a multifunctional cytokine which exerts a myriad of biological actions in different tissues and species. Many of these actions can perturb the normal regulation of energy metabolism. In adipose tissue, in particular, TNFα has been demonstrated to regulate or interfere with adipocyte metabolism at numerous sites including transcriptional regulation, glucose and fatty acid metabolism and hormone receptor signaling. The implications of these perturbations in disease states and the current understanding of the molecular mechanisms utilised by TNFα are discussed herein.
Adipose tissue, Glucose metabolism, Insulin resistance, Lipid metabolism, Tumor necrosis factor-α (TNFα)
19-29
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Hotamisligil, Gökhan S.
59ea0e53-a259-4224-9d24-d503c4a29d15
February 1999
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Hotamisligil, Gökhan S.
59ea0e53-a259-4224-9d24-d503c4a29d15
Sethi, Jaswinder K. and Hotamisligil, Gökhan S.
(1999)
The role of TNFα in adipocyte metabolism.
Seminars in Cell and Developmental Biology, 10 (1), .
(doi:10.1006/scdb.1998.0273).
Abstract
Tumor necrosis factor-alpha (TNFα) is a multifunctional cytokine which exerts a myriad of biological actions in different tissues and species. Many of these actions can perturb the normal regulation of energy metabolism. In adipose tissue, in particular, TNFα has been demonstrated to regulate or interfere with adipocyte metabolism at numerous sites including transcriptional regulation, glucose and fatty acid metabolism and hormone receptor signaling. The implications of these perturbations in disease states and the current understanding of the molecular mechanisms utilised by TNFα are discussed herein.
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Published date: February 1999
Keywords:
Adipose tissue, Glucose metabolism, Insulin resistance, Lipid metabolism, Tumor necrosis factor-α (TNFα)
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Local EPrints ID: 415403
URI: http://eprints.soton.ac.uk/id/eprint/415403
ISSN: 1084-9521
PURE UUID: 924564b4-28d2-4b3d-8ccb-8cd7a1569ecc
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Date deposited: 09 Nov 2017 17:30
Last modified: 16 Mar 2024 04:31
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Author:
Gökhan S. Hotamisligil
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