Thematic review series: Adipocyte Biology. Adipose tissue function and plasticity orchestrate nutritional adaptation
Thematic review series: Adipocyte Biology. Adipose tissue function and plasticity orchestrate nutritional adaptation
This review focuses on adipose tissue biology and introduces the concept of adipose tissue plasticity and expandability as key determinants of obesity-associated metabolic dysregulation. This concept is fundamental to our understanding of adipose tissue as a dynamic organ at the center of nutritional adaptation. Here, we summarize the current knowledge of the mechanisms by which adipose tissue can affect peripheral energy homeostasis, particularly in the context of overnutrition. Two mechanisms emerge that provide a molecular understanding for obesity-associated insulin resistance. These are a) the dysregulation of adipose tissue expandability and b) the abnormal production of adipokines. This knowledge has the potential to pave the way for novel therapeutic concepts and strategies for managing and/or correcting complications associated with obesity and the metabolic syndrome.
Adipokines, Insulin resistance, Lipotoxicity, Metabolic syndrome, Obesity
1253-1262
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Vidal-Puig, Antonio J.
bd6ec045-f9b8-48ff-ae86-a86a6a513435
June 2007
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Vidal-Puig, Antonio J.
bd6ec045-f9b8-48ff-ae86-a86a6a513435
Sethi, Jaswinder K. and Vidal-Puig, Antonio J.
(2007)
Thematic review series: Adipocyte Biology. Adipose tissue function and plasticity orchestrate nutritional adaptation.
Journal of Lipid Research, 48 (6), .
(doi:10.1194/jlr.R700005-JLR200).
Abstract
This review focuses on adipose tissue biology and introduces the concept of adipose tissue plasticity and expandability as key determinants of obesity-associated metabolic dysregulation. This concept is fundamental to our understanding of adipose tissue as a dynamic organ at the center of nutritional adaptation. Here, we summarize the current knowledge of the mechanisms by which adipose tissue can affect peripheral energy homeostasis, particularly in the context of overnutrition. Two mechanisms emerge that provide a molecular understanding for obesity-associated insulin resistance. These are a) the dysregulation of adipose tissue expandability and b) the abnormal production of adipokines. This knowledge has the potential to pave the way for novel therapeutic concepts and strategies for managing and/or correcting complications associated with obesity and the metabolic syndrome.
This record has no associated files available for download.
More information
e-pub ahead of print date: 20 March 2007
Published date: June 2007
Keywords:
Adipokines, Insulin resistance, Lipotoxicity, Metabolic syndrome, Obesity
Identifiers
Local EPrints ID: 415411
URI: http://eprints.soton.ac.uk/id/eprint/415411
ISSN: 0022-2275
PURE UUID: 7432bebc-1dc4-426b-a795-e5ffc72f7e47
Catalogue record
Date deposited: 09 Nov 2017 17:30
Last modified: 16 Mar 2024 04:31
Export record
Altmetrics
Contributors
Author:
Antonio J. Vidal-Puig
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
