Wnt signalling and the control of cellular metabolism
Wnt signalling and the control of cellular metabolism
At the cellular level, the biological processes of cell proliferation, growth arrest, differentiation and apoptosis are all tightly coupled to appropriate alterations in metabolic status. In the case of cell proliferation, this requires redirecting metabolic pathways to provide the fuel and basic components for new cells. Ultimately, the successful co-ordination of cell-specific biology with cellular metabolism underscores multicellular processes as diverse as embryonic development, adult tissue remodelling and cancer cell biology. The Wnt signalling network has been implicated in all of these areas. While each of theWnt-dependent signalling pathways are being individually delineated in a range of experimental systems, our understanding of how they integrate and regulate cellular metabolism is still in its infancy. In the present review we reassess the roles of Wnt signalling in functionally linking cellular metabolism to tissue development and function.
Diabetes, Metabolic syndrome, Metabolism, Obesity, Wnt signalling
1-17
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Vidal-Puig, Antonio
7d46d380-1b9d-40cb-90a3-72679e143036
1 April 2010
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Vidal-Puig, Antonio
7d46d380-1b9d-40cb-90a3-72679e143036
Sethi, Jaswinder K. and Vidal-Puig, Antonio
(2010)
Wnt signalling and the control of cellular metabolism.
Biochemical Journal, 427 (1), .
(doi:10.1042/BJ20091866).
Abstract
At the cellular level, the biological processes of cell proliferation, growth arrest, differentiation and apoptosis are all tightly coupled to appropriate alterations in metabolic status. In the case of cell proliferation, this requires redirecting metabolic pathways to provide the fuel and basic components for new cells. Ultimately, the successful co-ordination of cell-specific biology with cellular metabolism underscores multicellular processes as diverse as embryonic development, adult tissue remodelling and cancer cell biology. The Wnt signalling network has been implicated in all of these areas. While each of theWnt-dependent signalling pathways are being individually delineated in a range of experimental systems, our understanding of how they integrate and regulate cellular metabolism is still in its infancy. In the present review we reassess the roles of Wnt signalling in functionally linking cellular metabolism to tissue development and function.
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e-pub ahead of print date: 15 March 2010
Published date: 1 April 2010
Keywords:
Diabetes, Metabolic syndrome, Metabolism, Obesity, Wnt signalling
Identifiers
Local EPrints ID: 415419
URI: http://eprints.soton.ac.uk/id/eprint/415419
ISSN: 0264-6021
PURE UUID: 930cac22-7e0c-4a03-8684-8c04c5d102ac
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Date deposited: 09 Nov 2017 17:30
Last modified: 16 Mar 2024 04:31
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Author:
Antonio Vidal-Puig
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