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Evaluating the effect of immune cells on the outcome of patients with mesothelioma

Evaluating the effect of immune cells on the outcome of patients with mesothelioma
Evaluating the effect of immune cells on the outcome of patients with mesothelioma

BACKGROUND: We systematically assessed the prognostic and predictive value of infiltrating adaptive and innate immune cells in a large cohort of patients with advanced mesothelioma.

METHODS: A tissue microarray from 302 samples was constructed. Markers of adaptive immune response in T-cells (CD8(+), FOXP3(+), CD4(+), CD45RO(+), CD3(+)) and B-cells (CD20(+)), and of innate immune response; neutrophils (NP57(+)), natural killer cells (CD56(+)) and macrophages (CD68(+)) were evaluated.

RESULTS: We found that in the epithelioid tumours, high CD4(+) and CD20(+) counts, and low FOXP3(+), CD68(+) and NP57(+) counts linked to better outcome. In the non-epithelioid group low CD8(+) and low FOXP3(+) counts were beneficial.On multivariate analysis low FOXP3(+) remained independently associated with survival in both groups. In the epithelioid group additionally high CD4(+), high CD20(+), and low NP57(+) counts were prognostic.

CONCLUSIONS: Our data demonstrate for the first time, in predominately advanced disease, the association of key markers of adaptive and innate immunity with survival and the differential effect of histology. A better understanding of the immunological drivers of the different subtypes of mesothelioma will assist prognostication and disease-specific clinical decision-making.

Journal Article
0007-0920
1341-1348
Chee, Serena J.
771bea7e-9b53-4182-8370-298ace4c7298
Lopez, Maria
4b68aeef-48d4-488f-9102-559d9e6d0a30
Mellows, Toby
fcef03c9-a37f-4ef1-aee7-c95109805d5d
Moutasim, Karwan A.
af7dd711-f6df-44f7-8c57-052bf15303af
Harris, Scott
19ea097b-df15-4f0f-be19-8ac42c190028
Clarke, James, Ian
867dce7c-1a12-42f2-acc3-63c440ff0024
Vijayanand, Pandurangan
79514f33-66cf-47cc-a8fa-46bbfc21b7d1
Thomas, Gareth J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
Ottensmeier, Christian H.
42b8a398-baac-4843-a3d6-056225675797
Chee, Serena J.
771bea7e-9b53-4182-8370-298ace4c7298
Lopez, Maria
4b68aeef-48d4-488f-9102-559d9e6d0a30
Mellows, Toby
fcef03c9-a37f-4ef1-aee7-c95109805d5d
Moutasim, Karwan A.
af7dd711-f6df-44f7-8c57-052bf15303af
Harris, Scott
19ea097b-df15-4f0f-be19-8ac42c190028
Clarke, James, Ian
867dce7c-1a12-42f2-acc3-63c440ff0024
Vijayanand, Pandurangan
79514f33-66cf-47cc-a8fa-46bbfc21b7d1
Thomas, Gareth J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
Ottensmeier, Christian H.
42b8a398-baac-4843-a3d6-056225675797

Chee, Serena J., Lopez, Maria, Mellows, Toby, Moutasim, Karwan A., Harris, Scott, Clarke, James, Ian, Vijayanand, Pandurangan, Thomas, Gareth J. and Ottensmeier, Christian H. (2017) Evaluating the effect of immune cells on the outcome of patients with mesothelioma British Journal of Cancer, 117, (9), pp. 1341-1348. (doi:10.1038/bjc.2017.269).

Record type: Article

Abstract

BACKGROUND: We systematically assessed the prognostic and predictive value of infiltrating adaptive and innate immune cells in a large cohort of patients with advanced mesothelioma.

METHODS: A tissue microarray from 302 samples was constructed. Markers of adaptive immune response in T-cells (CD8(+), FOXP3(+), CD4(+), CD45RO(+), CD3(+)) and B-cells (CD20(+)), and of innate immune response; neutrophils (NP57(+)), natural killer cells (CD56(+)) and macrophages (CD68(+)) were evaluated.

RESULTS: We found that in the epithelioid tumours, high CD4(+) and CD20(+) counts, and low FOXP3(+), CD68(+) and NP57(+) counts linked to better outcome. In the non-epithelioid group low CD8(+) and low FOXP3(+) counts were beneficial.On multivariate analysis low FOXP3(+) remained independently associated with survival in both groups. In the epithelioid group additionally high CD4(+), high CD20(+), and low NP57(+) counts were prognostic.

CONCLUSIONS: Our data demonstrate for the first time, in predominately advanced disease, the association of key markers of adaptive and innate immunity with survival and the differential effect of histology. A better understanding of the immunological drivers of the different subtypes of mesothelioma will assist prognostication and disease-specific clinical decision-making.

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More information

Accepted/In Press date: 20 July 2017
e-pub ahead of print date: 17 August 2017
Published date: 24 October 2017
Keywords: Journal Article

Identifiers

Local EPrints ID: 415464
URI: http://eprints.soton.ac.uk/id/eprint/415464
ISSN: 0007-0920
PURE UUID: 2f5cae8e-f0ba-4862-a6a6-e8e0f0d1b383

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Date deposited: 10 Nov 2017 17:30
Last modified: 10 Nov 2017 17:30

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Contributors

Author: Serena J. Chee
Author: Maria Lopez
Author: Toby Mellows
Author: Scott Harris
Author: James, Ian Clarke
Author: Pandurangan Vijayanand

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