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Anti-cytokine autoantibodies in a patient with a heterozygous NFKB2 mutation

Anti-cytokine autoantibodies in a patient with a heterozygous NFKB2 mutation
Anti-cytokine autoantibodies in a patient with a heterozygous NFKB2 mutation
We report a family with a heterozygous NFKB2 mutation in which anti-cytokine autoantibodies were identified in one individual. Rituximab therapy for autoantibodies led to a reduction in anti-cytokine autoantibodies and a marked improvement in infectious susceptibility.
0091-6749
Ramakrishnan, Kesava
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Rae, William
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Barcenas-Morales, Gabriela
eedd9c75-776a-4fe0-a06e-88621e56cb15
Gao, Yifang
eea234ba-f566-4f21-a65e-234b84cba285
Pengelly, Reuben
af97c0c1-b568-415c-9f59-1823b65be76d
Patel, Sanjay
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Kumararatne, Dinkantha
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Ennis, Sarah
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Doffinger, Rainer
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Faust, Saul N.
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Williams, Anthony
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Ramakrishnan, Kesava
c7c565f4-69a5-4c57-a277-1497c01aff1d
Rae, William
8746e0ae-b868-4356-9c89-fe78600cf427
Barcenas-Morales, Gabriela
eedd9c75-776a-4fe0-a06e-88621e56cb15
Gao, Yifang
eea234ba-f566-4f21-a65e-234b84cba285
Pengelly, Reuben
af97c0c1-b568-415c-9f59-1823b65be76d
Patel, Sanjay
4ea4db7c-bf45-41af-8d57-4e925f24474c
Kumararatne, Dinkantha
c5ebb61c-5ada-4985-bb9d-f14edc7d785e
Ennis, Sarah
7b57f188-9d91-4beb-b217-09856146f1e9
Doffinger, Rainer
7057457b-d2c9-471e-91f2-138dca9beac6
Faust, Saul N.
f97df780-9f9b-418e-b349-7adf63e150c1
Williams, Anthony
973ff46f-46f1-4d7c-b27d-0f53221e4c44

Ramakrishnan, Kesava, Rae, William, Barcenas-Morales, Gabriela, Gao, Yifang, Pengelly, Reuben, Patel, Sanjay, Kumararatne, Dinkantha, Ennis, Sarah, Doffinger, Rainer, Faust, Saul N. and Williams, Anthony (2017) Anti-cytokine autoantibodies in a patient with a heterozygous NFKB2 mutation. Journal of Allergy and Clinical Immunology. (doi:10.1016/j.jaci.2017.11.014).

Record type: Letter

Abstract

We report a family with a heterozygous NFKB2 mutation in which anti-cytokine autoantibodies were identified in one individual. Rituximab therapy for autoantibodies led to a reduction in anti-cytokine autoantibodies and a marked improvement in infectious susceptibility.

Text
WR_JACI_171023_CLEAN_manuscript - Accepted Manuscript
Available under License Creative Commons Attribution Non-commercial No Derivatives.
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Accepted/In Press date: 1 November 2017
e-pub ahead of print date: 7 December 2017
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Identifiers

Local EPrints ID: 415521
URI: http://eprints.soton.ac.uk/id/eprint/415521
DOI: doi:10.1016/j.jaci.2017.11.014
ISSN: 0091-6749
PURE UUID: ca2ba46d-9c63-4dfe-97a3-ac4b17f7fd95
ORCID for Reuben Pengelly: ORCID iD orcid.org/0000-0001-7022-645X
ORCID for Sarah Ennis: ORCID iD orcid.org/0000-0003-2648-0869
ORCID for Saul N. Faust: ORCID iD orcid.org/0000-0003-3410-7642

Catalogue record

Date deposited: 14 Nov 2017 17:30
Last modified: 16 Mar 2024 05:55

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Contributors

Author: Kesava Ramakrishnan
Author: William Rae
Author: Gabriela Barcenas-Morales
Author: Yifang Gao
Author: Reuben Pengelly ORCID iD
Author: Sanjay Patel
Author: Dinkantha Kumararatne
Author: Sarah Ennis ORCID iD
Author: Rainer Doffinger
Author: Saul N. Faust ORCID iD
Author: Anthony Williams

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