The University of Southampton
University of Southampton Institutional Repository

Clinical relevance, prognostic potential, and therapeutic strategies of noncoding RNAs in cancer

Clinical relevance, prognostic potential, and therapeutic strategies of noncoding RNAs in cancer
Clinical relevance, prognostic potential, and therapeutic strategies of noncoding RNAs in cancer
Noncoding RNAs (ncRNAs) are master regulators of the genome, controlling the most fundamental of cellular processes. Several hundred studies have demonstrated their dysregulation across a range of cancer types, and translational follow-on studies have led to the development of putative ncRNA biomarkers for identification and staging of cancer. Additionally, mechanistic studies have clearly identified key functions for ncRNAs in cancer progression, and highlighted actionable pathways to be targeted by ncRNA-directed therapies. Consequently, ncRNA-derived therapeutics is now entering later stage clinical trials. In this chapter, we describe the classification of ncRNAs, their biology, and their potential clinical applications.
429-445
Elsevier Science & Technology Books
Bhome, Rahul
d7b1e0d3-5925-460a-871d-5f52f69c649b
House, Louise
cae26416-74fd-4c8b-8463-708cd5d1c6b1
Emo, Katherine
ae0ee96d-2d3e-4833-aef3-2ea5a75a8a94
Sayan, Abdulkadir
d1dbbcad-9c53-47c1-8b7e-1b45cc56e077
Mirnezami, Alex
b3c7aee7-46a4-404c-bfe3-f72388e0bc94
Bhome, Rahul
d7b1e0d3-5925-460a-871d-5f52f69c649b
House, Louise
cae26416-74fd-4c8b-8463-708cd5d1c6b1
Emo, Katherine
ae0ee96d-2d3e-4833-aef3-2ea5a75a8a94
Sayan, Abdulkadir
d1dbbcad-9c53-47c1-8b7e-1b45cc56e077
Mirnezami, Alex
b3c7aee7-46a4-404c-bfe3-f72388e0bc94

Bhome, Rahul, House, Louise, Emo, Katherine, Sayan, Abdulkadir and Mirnezami, Alex (2018) Clinical relevance, prognostic potential, and therapeutic strategies of noncoding RNAs in cancer. In, Cancer and Noncoding RNAs. 1 ed. Elsevier Science & Technology Books, pp. 429-445. ,

Record type: Book Section

Abstract

Noncoding RNAs (ncRNAs) are master regulators of the genome, controlling the most fundamental of cellular processes. Several hundred studies have demonstrated their dysregulation across a range of cancer types, and translational follow-on studies have led to the development of putative ncRNA biomarkers for identification and staging of cancer. Additionally, mechanistic studies have clearly identified key functions for ncRNAs in cancer progression, and highlighted actionable pathways to be targeted by ncRNA-directed therapies. Consequently, ncRNA-derived therapeutics is now entering later stage clinical trials. In this chapter, we describe the classification of ncRNAs, their biology, and their potential clinical applications.

Full text not available from this repository.

More information

e-pub ahead of print date: 13 October 2017
Published date: 2018

Identifiers

Local EPrints ID: 415601
URI: https://eprints.soton.ac.uk/id/eprint/415601
PURE UUID: fe429346-1317-4fac-9f9e-eee87cf47ef7

Catalogue record

Date deposited: 16 Nov 2017 17:30
Last modified: 22 Feb 2018 17:31

Export record

Contributors

Author: Rahul Bhome
Author: Louise House
Author: Katherine Emo
Author: Alex Mirnezami

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Library staff edit
Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×