Clinical relevance, prognostic potential, and therapeutic strategies of noncoding RNAs in cancer
Clinical relevance, prognostic potential, and therapeutic strategies of noncoding RNAs in cancer
Noncoding RNAs (ncRNAs) are master regulators of the genome, controlling the most fundamental of cellular processes. Several hundred studies have demonstrated their dysregulation across a range of cancer types, and translational follow-on studies have led to the development of putative ncRNA biomarkers for identification and staging of cancer. Additionally, mechanistic studies have clearly identified key functions for ncRNAs in cancer progression, and highlighted actionable pathways to be targeted by ncRNA-directed therapies. Consequently, ncRNA-derived therapeutics is now entering later stage clinical trials. In this chapter, we describe the classification of ncRNAs, their biology, and their potential clinical applications.
429-445
Bhome, Rahul
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House, Louise
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Emo, Katherine
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Sayan, Abdulkadir
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Mirnezami, Alex
b3c7aee7-46a4-404c-bfe3-f72388e0bc94
2018
Bhome, Rahul
d7b1e0d3-5925-460a-871d-5f52f69c649b
House, Louise
cae26416-74fd-4c8b-8463-708cd5d1c6b1
Emo, Katherine
ae0ee96d-2d3e-4833-aef3-2ea5a75a8a94
Sayan, Abdulkadir
d1dbbcad-9c53-47c1-8b7e-1b45cc56e077
Mirnezami, Alex
b3c7aee7-46a4-404c-bfe3-f72388e0bc94
Bhome, Rahul, House, Louise, Emo, Katherine, Sayan, Abdulkadir and Mirnezami, Alex
(2018)
Clinical relevance, prognostic potential, and therapeutic strategies of noncoding RNAs in cancer.
In,
Cancer and Noncoding RNAs.
1 ed.
Academic Press, .
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Book Section
Abstract
Noncoding RNAs (ncRNAs) are master regulators of the genome, controlling the most fundamental of cellular processes. Several hundred studies have demonstrated their dysregulation across a range of cancer types, and translational follow-on studies have led to the development of putative ncRNA biomarkers for identification and staging of cancer. Additionally, mechanistic studies have clearly identified key functions for ncRNAs in cancer progression, and highlighted actionable pathways to be targeted by ncRNA-directed therapies. Consequently, ncRNA-derived therapeutics is now entering later stage clinical trials. In this chapter, we describe the classification of ncRNAs, their biology, and their potential clinical applications.
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e-pub ahead of print date: 13 October 2017
Published date: 2018
Identifiers
Local EPrints ID: 415601
URI: http://eprints.soton.ac.uk/id/eprint/415601
PURE UUID: fe429346-1317-4fac-9f9e-eee87cf47ef7
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Date deposited: 16 Nov 2017 17:30
Last modified: 05 Jan 2024 02:48
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Contributors
Author:
Louise House
Author:
Katherine Emo
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