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Comparison of microsphere penetration with LC Bead LUMI™ versus other commercial microspheres

Comparison of microsphere penetration with LC Bead LUMI™ versus other commercial microspheres
Comparison of microsphere penetration with LC Bead LUMI™ versus other commercial microspheres
The purpose of this study was to evaluate LC Bead LUMI™ (40–90 µm and 70–150 µm) in order to determine if their increased resistance to compression influences microsphere penetration and distribution compared to more compressible commercial microspheres. LC Bead LUMI™ 40–90 µm and 70–150 µm, LC BeadM1® 70–150 µm, Embozene™ 40 µm and Embozene™ 100 µm size and distributions were measured using optical microscopy. Penetration in vitro was evaluated using an established ‘plate model’, consisting of a calibrated tapered gap between a glass plate and plastic housing to allow visual observation of microsphere penetration depth. Behaviour in vivo was assessed using a rabbit renal embolization model with histopathologic confirmation of vessel penetration depth. Penetration behaviour in vitro was reproducible and commensurate with the measured microsphere size, the smaller the microsphere the deeper the penetration. Comparison of the microsphere diameter measured on the 2D plate model versus the corresponding average microsphere size measured by histopathology in the kidney showed no significant differences (p = > 0.05 Mann-Whitney, demonstrating good in vitro - in vivo predictive capabilities of the plate model) confirming predictable performance for LC Bead LUMI™ (40–90 µm and 70–150 µm) based on microsphere size, their increased rigidity having no bearing on their depth of penetration and distribution. An assessment of a LC Bead LUMI™ (40–90 µm and 70–150 µm) has shown that despite having greater resistance to compression, these microspheres behave in a predictable manner within in vitro and in vivo models comparable with more compressible microspheres of similar sizes.
Embolization microspheres, penetration plate model, renal embolzation model, compressive modulus
1751-6161
46-55
Caine, Marcus
b32f8e4b-3a11-47eb-9600-2eea10e87b8a
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Guo, Wei
2addd16f-55f9-4dff-be7b-7232d6c22fd3
Ashrafi, Koorosh
ee74e5e8-8af7-4ae7-b11e-2a0bcfb656ac
Bascal, Zainab
04395e8c-79d6-4c15-bbce-1df2fdd8c8f4
Kilpatrick, Hugh
96d6d7d8-f83e-4984-a65a-53a17810829f
Dunn, Anthony
efea14f8-e3ea-4a7b-b0d2-11a592feba03
Grey, David
1c9bb5ce-c740-47d1-a82f-d2eeada1d6c7
Bushby, Rosemary
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Bushby, Andrew
bbff3706-c70c-403c-b9dc-cee1a7a73eff
Willis, Sean L.
c52887ff-55d1-4910-81db-dd70448db56f
Dreher, Matthew R.
dd5e6291-6a16-4ad2-ae5e-3b50ef107769
Lewis, Andrew L.
f604ae82-4d54-4f04-ac8f-e7bc6f1f832c
Caine, Marcus
b32f8e4b-3a11-47eb-9600-2eea10e87b8a
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Guo, Wei
2addd16f-55f9-4dff-be7b-7232d6c22fd3
Ashrafi, Koorosh
ee74e5e8-8af7-4ae7-b11e-2a0bcfb656ac
Bascal, Zainab
04395e8c-79d6-4c15-bbce-1df2fdd8c8f4
Kilpatrick, Hugh
96d6d7d8-f83e-4984-a65a-53a17810829f
Dunn, Anthony
efea14f8-e3ea-4a7b-b0d2-11a592feba03
Grey, David
1c9bb5ce-c740-47d1-a82f-d2eeada1d6c7
Bushby, Rosemary
57477566-4626-4024-8b05-36999ce1bd8c
Bushby, Andrew
bbff3706-c70c-403c-b9dc-cee1a7a73eff
Willis, Sean L.
c52887ff-55d1-4910-81db-dd70448db56f
Dreher, Matthew R.
dd5e6291-6a16-4ad2-ae5e-3b50ef107769
Lewis, Andrew L.
f604ae82-4d54-4f04-ac8f-e7bc6f1f832c

Caine, Marcus, Zhang, Xunli, Hill, Martyn, Guo, Wei, Ashrafi, Koorosh, Bascal, Zainab, Kilpatrick, Hugh, Dunn, Anthony, Grey, David, Bushby, Rosemary, Bushby, Andrew, Willis, Sean L., Dreher, Matthew R. and Lewis, Andrew L. (2018) Comparison of microsphere penetration with LC Bead LUMI™ versus other commercial microspheres. Journal of the Mechanical Behavior of Biomedical Materials, 78, 46-55. (doi:10.1016/j.jmbbm.2017.10.034).

Record type: Article

Abstract

The purpose of this study was to evaluate LC Bead LUMI™ (40–90 µm and 70–150 µm) in order to determine if their increased resistance to compression influences microsphere penetration and distribution compared to more compressible commercial microspheres. LC Bead LUMI™ 40–90 µm and 70–150 µm, LC BeadM1® 70–150 µm, Embozene™ 40 µm and Embozene™ 100 µm size and distributions were measured using optical microscopy. Penetration in vitro was evaluated using an established ‘plate model’, consisting of a calibrated tapered gap between a glass plate and plastic housing to allow visual observation of microsphere penetration depth. Behaviour in vivo was assessed using a rabbit renal embolization model with histopathologic confirmation of vessel penetration depth. Penetration behaviour in vitro was reproducible and commensurate with the measured microsphere size, the smaller the microsphere the deeper the penetration. Comparison of the microsphere diameter measured on the 2D plate model versus the corresponding average microsphere size measured by histopathology in the kidney showed no significant differences (p = > 0.05 Mann-Whitney, demonstrating good in vitro - in vivo predictive capabilities of the plate model) confirming predictable performance for LC Bead LUMI™ (40–90 µm and 70–150 µm) based on microsphere size, their increased rigidity having no bearing on their depth of penetration and distribution. An assessment of a LC Bead LUMI™ (40–90 µm and 70–150 µm) has shown that despite having greater resistance to compression, these microspheres behave in a predictable manner within in vitro and in vivo models comparable with more compressible microspheres of similar sizes.

Text Caine et al JMBBM Revised Final+Figs - Accepted Manuscript
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Accepted/In Press date: 30 October 2017
e-pub ahead of print date: 31 October 2017
Published date: February 2018
Keywords: Embolization microspheres, penetration plate model, renal embolzation model, compressive modulus

Identifiers

Local EPrints ID: 415690
URI: https://eprints.soton.ac.uk/id/eprint/415690
ISSN: 1751-6161
PURE UUID: 375a1726-bb21-48cd-897c-4c1925ea98d5
ORCID for Martyn Hill: ORCID iD orcid.org/0000-0001-6448-9448

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Date deposited: 20 Nov 2017 17:30
Last modified: 16 Feb 2018 17:32

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Contributors

Author: Marcus Caine
Author: Xunli Zhang
Author: Martyn Hill ORCID iD
Author: Wei Guo
Author: Koorosh Ashrafi
Author: Zainab Bascal
Author: Hugh Kilpatrick
Author: Anthony Dunn
Author: David Grey
Author: Rosemary Bushby
Author: Andrew Bushby
Author: Sean L. Willis
Author: Matthew R. Dreher
Author: Andrew L. Lewis

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