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Grip strength and inflammatory biomarker profiles in very old adults

Grip strength and inflammatory biomarker profiles in very old adults
Grip strength and inflammatory biomarker profiles in very old adults
Background: weak grip strength (GS) and chronic inflammation have been implicated in the aetiology of sarcopenia in older adults. Given the interrelationships between inflammatory biomarkers, a summary variable may provide better insight into the relationship between inflammation and muscle strength. This approach has not been investigated in very old adults (aged ≥85) who are at highest risk of muscle weakness.

Methods: we used mixed models to explore the prospective association between GS over 5 years in 845 participants in the Newcastle 85+ Study, and inflammatory components identified by principal component analysis (PCA). Cut-offs of ≤27 kg (men) and ≤16 (women) were used to define sub-cohorts with weak and normal GS at each assessment.

Results: PCA identified three components, which explained 70% of the total variance in seven baseline biomarkers. Basal interleukin-6 (IL-6) and tumour necrosis factor (TNF-α) had the highest loadings on Component 1; stimulated IL-6 and TNF-α and homocysteine the highest on Component 2; high-sensitivity C-reactive protein (hsCRP) loaded positively and albumin negatively to Component 3. In adjusted mixed models, only Component 3 was associated with GS. One SD increase of Component 3 was associated with a 0.41 kg lower GS initially (P = 0.03) in all participants, but not with GS decline over time. Similar conclusions held for those in the weak and normal GS sub-cohorts.

Conclusion: an inflammatory profile including hsCRP and albumin was independently associated with baseline GS. Future studies linking inflammatory profiles and muscle strength are needed to corroborate these findings in older adults.
0002-0729
Granic, A.
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Davies, K.
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Martin-Ruiz, C.
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Jagger, C.
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Kirkwood, T.B.
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von Zglinicki, T.
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Aihie Sayer, Avan
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Granic, A.
8245c73d-845e-43c2-8f31-7e33242c1d57
Davies, K.
d9c4d70d-b2c0-4952-b59d-bd4dd5083331
Martin-Ruiz, C.
a0eefd14-84b2-4ea6-aaf3-4d2fe406e9e2
Jagger, C.
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Kirkwood, T.B.
a8b3aac4-6699-49b0-b506-961451770bdb
von Zglinicki, T.
19e0e168-991c-4239-8d03-9c8f35a0fc8f
Aihie Sayer, Avan
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb

Granic, A., Davies, K., Martin-Ruiz, C., Jagger, C., Kirkwood, T.B., von Zglinicki, T. and Aihie Sayer, Avan (2017) Grip strength and inflammatory biomarker profiles in very old adults. Age and Ageing, 46 (6). (doi:10.1093/ageing/afx088).

Record type: Article

Abstract

Background: weak grip strength (GS) and chronic inflammation have been implicated in the aetiology of sarcopenia in older adults. Given the interrelationships between inflammatory biomarkers, a summary variable may provide better insight into the relationship between inflammation and muscle strength. This approach has not been investigated in very old adults (aged ≥85) who are at highest risk of muscle weakness.

Methods: we used mixed models to explore the prospective association between GS over 5 years in 845 participants in the Newcastle 85+ Study, and inflammatory components identified by principal component analysis (PCA). Cut-offs of ≤27 kg (men) and ≤16 (women) were used to define sub-cohorts with weak and normal GS at each assessment.

Results: PCA identified three components, which explained 70% of the total variance in seven baseline biomarkers. Basal interleukin-6 (IL-6) and tumour necrosis factor (TNF-α) had the highest loadings on Component 1; stimulated IL-6 and TNF-α and homocysteine the highest on Component 2; high-sensitivity C-reactive protein (hsCRP) loaded positively and albumin negatively to Component 3. In adjusted mixed models, only Component 3 was associated with GS. One SD increase of Component 3 was associated with a 0.41 kg lower GS initially (P = 0.03) in all participants, but not with GS decline over time. Similar conclusions held for those in the weak and normal GS sub-cohorts.

Conclusion: an inflammatory profile including hsCRP and albumin was independently associated with baseline GS. Future studies linking inflammatory profiles and muscle strength are needed to corroborate these findings in older adults.

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Accepted/In Press date: 11 May 2017
e-pub ahead of print date: 25 May 2017

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Local EPrints ID: 415701
URI: http://eprints.soton.ac.uk/id/eprint/415701
ISSN: 0002-0729
PURE UUID: b45d9cc4-37be-417a-8a39-747c0e030549

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Date deposited: 20 Nov 2017 17:30
Last modified: 06 Oct 2020 19:49

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Contributors

Author: A. Granic
Author: K. Davies
Author: C. Martin-Ruiz
Author: C. Jagger
Author: T.B. Kirkwood
Author: T. von Zglinicki
Author: Avan Aihie Sayer

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