The University of Southampton
University of Southampton Institutional Repository

Measuring molecular parity nonconservation using nuclear-magnetic-resonance spectroscopy

Measuring molecular parity nonconservation using nuclear-magnetic-resonance spectroscopy
Measuring molecular parity nonconservation using nuclear-magnetic-resonance spectroscopy
The weak interaction does not conserve parity and therefore induces energy shifts in chiral enantiomers that should in principle be detectable in molecular spectra. Unfortunately, the magnitude of the expected shifts are small and in spectra of a mixture of enantiomers, the energy shifts are not resolvable. We propose a nuclear-magnetic-resonance (NMR) experiment in which we titrate the chirality (enantiomeric excess) of a solvent and measure the diasteriomeric splitting in the spectra of a chiral solute in order to search for an anomalous offset due to parity nonconservation (PNC). We present a proof-of-principle experiment in which we search for PNC in the 13C resonances of small molecules, and use the 1H resonances, which are insensitive to PNC, as an internal reference. We set a constraint on molecular PNC in 13C chemical shifts at a level of 10−5 ppm, and provide a discussion of important considerations in the search for molecular PNC using NMR spectroscopy.
2469-9926
Eills, J.
23130b21-68fa-4c8b-9399-e55f2e71ef36
Blanchard, J. W.
3bb7de6e-f147-4527-9b1c-fbf8cb138f47
Bougas, L.
b40310ef-93d5-4219-9840-4b79f3ff31e1
Kozlov, M. G.
387feb40-ddd7-4f9c-aa48-748360c8278d
Pines, A.
2ee79762-f661-4cab-bda6-61fff9b3d2d4
Budker, D.
8074acc0-30e8-4c4a-9086-0fcec0ede8ff
Eills, J.
23130b21-68fa-4c8b-9399-e55f2e71ef36
Blanchard, J. W.
3bb7de6e-f147-4527-9b1c-fbf8cb138f47
Bougas, L.
b40310ef-93d5-4219-9840-4b79f3ff31e1
Kozlov, M. G.
387feb40-ddd7-4f9c-aa48-748360c8278d
Pines, A.
2ee79762-f661-4cab-bda6-61fff9b3d2d4
Budker, D.
8074acc0-30e8-4c4a-9086-0fcec0ede8ff

Eills, J., Blanchard, J. W., Bougas, L., Kozlov, M. G., Pines, A. and Budker, D. (2017) Measuring molecular parity nonconservation using nuclear-magnetic-resonance spectroscopy. Physical Review A, 96 (4), [042119]. (doi:10.1103/PhysRevA.96.042119).

Record type: Article

Abstract

The weak interaction does not conserve parity and therefore induces energy shifts in chiral enantiomers that should in principle be detectable in molecular spectra. Unfortunately, the magnitude of the expected shifts are small and in spectra of a mixture of enantiomers, the energy shifts are not resolvable. We propose a nuclear-magnetic-resonance (NMR) experiment in which we titrate the chirality (enantiomeric excess) of a solvent and measure the diasteriomeric splitting in the spectra of a chiral solute in order to search for an anomalous offset due to parity nonconservation (PNC). We present a proof-of-principle experiment in which we search for PNC in the 13C resonances of small molecules, and use the 1H resonances, which are insensitive to PNC, as an internal reference. We set a constraint on molecular PNC in 13C chemical shifts at a level of 10−5 ppm, and provide a discussion of important considerations in the search for molecular PNC using NMR spectroscopy.

Text
PhysRevA.96.042119 - Version of Record
Available under License Other.
Download (648kB)
Text
PhysRevA.96.042119 (Accepted version)
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 2 September 2017
e-pub ahead of print date: 30 October 2017
Published date: October 2017

Identifiers

Local EPrints ID: 415703
URI: http://eprints.soton.ac.uk/id/eprint/415703
ISSN: 2469-9926
PURE UUID: 6f4ee9d6-151a-4bf2-85ba-b48e8d60c21a

Catalogue record

Date deposited: 20 Nov 2017 17:30
Last modified: 06 Oct 2020 16:54

Export record

Altmetrics

Contributors

Author: J. Eills
Author: J. W. Blanchard
Author: L. Bougas
Author: M. G. Kozlov
Author: A. Pines
Author: D. Budker

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×