Measuring molecular parity nonconservation using nuclear-magnetic-resonance spectroscopy
Measuring molecular parity nonconservation using nuclear-magnetic-resonance spectroscopy
The weak interaction does not conserve parity and therefore induces energy shifts in chiral enantiomers that should in principle be detectable in molecular spectra. Unfortunately, the magnitude of the expected shifts are small and in spectra of a mixture of enantiomers, the energy shifts are not resolvable. We propose a nuclear-magnetic-resonance (NMR) experiment in which we titrate the chirality (enantiomeric excess) of a solvent and measure the diasteriomeric splitting in the spectra of a chiral solute in order to search for an anomalous offset due to parity nonconservation (PNC). We present a proof-of-principle experiment in which we search for PNC in the 13C resonances of small molecules, and use the 1H resonances, which are insensitive to PNC, as an internal reference. We set a constraint on molecular PNC in 13C chemical shifts at a level of 10−5 ppm, and provide a discussion of important considerations in the search for molecular PNC using NMR spectroscopy.
Eills, J.
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Blanchard, J. W.
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Bougas, L.
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Kozlov, M. G.
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Pines, A.
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Budker, D.
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October 2017
Eills, J.
23130b21-68fa-4c8b-9399-e55f2e71ef36
Blanchard, J. W.
3bb7de6e-f147-4527-9b1c-fbf8cb138f47
Bougas, L.
b40310ef-93d5-4219-9840-4b79f3ff31e1
Kozlov, M. G.
387feb40-ddd7-4f9c-aa48-748360c8278d
Pines, A.
2ee79762-f661-4cab-bda6-61fff9b3d2d4
Budker, D.
8074acc0-30e8-4c4a-9086-0fcec0ede8ff
Eills, J., Blanchard, J. W., Bougas, L., Kozlov, M. G., Pines, A. and Budker, D.
(2017)
Measuring molecular parity nonconservation using nuclear-magnetic-resonance spectroscopy.
Physical Review A, 96 (4), [042119].
(doi:10.1103/PhysRevA.96.042119).
Abstract
The weak interaction does not conserve parity and therefore induces energy shifts in chiral enantiomers that should in principle be detectable in molecular spectra. Unfortunately, the magnitude of the expected shifts are small and in spectra of a mixture of enantiomers, the energy shifts are not resolvable. We propose a nuclear-magnetic-resonance (NMR) experiment in which we titrate the chirality (enantiomeric excess) of a solvent and measure the diasteriomeric splitting in the spectra of a chiral solute in order to search for an anomalous offset due to parity nonconservation (PNC). We present a proof-of-principle experiment in which we search for PNC in the 13C resonances of small molecules, and use the 1H resonances, which are insensitive to PNC, as an internal reference. We set a constraint on molecular PNC in 13C chemical shifts at a level of 10−5 ppm, and provide a discussion of important considerations in the search for molecular PNC using NMR spectroscopy.
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PhysRevA.96.042119
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Accepted/In Press date: 2 September 2017
e-pub ahead of print date: 30 October 2017
Published date: October 2017
Identifiers
Local EPrints ID: 415703
URI: http://eprints.soton.ac.uk/id/eprint/415703
ISSN: 2469-9926
PURE UUID: 6f4ee9d6-151a-4bf2-85ba-b48e8d60c21a
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Date deposited: 20 Nov 2017 17:30
Last modified: 15 Mar 2024 16:54
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Contributors
Author:
J. Eills
Author:
J. W. Blanchard
Author:
L. Bougas
Author:
M. G. Kozlov
Author:
A. Pines
Author:
D. Budker
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