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Evidence for enhanced multi-component behaviour in Tourette syndrome - an EEG study

Evidence for enhanced multi-component behaviour in Tourette syndrome - an EEG study
Evidence for enhanced multi-component behaviour in Tourette syndrome - an EEG study
Evidence suggests that Tourette syndrome is characterized by an increase in dopamine transmission and structural as well as functional changes in fronto-striatal circuits that might lead to enhanced multi-component behaviour integration. Behavioural and neurophysiological data regarding multi-component behaviour was collected from 15 patients with Tourette syndrome (mean age = 30.40 ± 11.10) and 15 healthy controls (27.07 ± 5.44), using the stop-change task. In this task, participants are asked to sometimes withhold responses to a Go stimulus (stop cue) and change hands to respond to an alternative Go stimulus (change cue). Different onset asynchronies between stop and change cues were implemented (0 and 300 ms) in order to vary task difficulty. Tourette patients responded more accurately than healthy controls when there was no delay between stop and change stimulus, while there was no difference in the 300 ms delay condition. This performance advantage was reflected in a smaller P3 event related potential. Enhanced multi-component behaviour in Tourette syndrome is likely based on an enhanced ability to integrate information from multiple sources and translate it into an appropriate response sequence. This may be a consequence of chronic tic control in these patients, or a known fronto-striatal networks hyperconnectivity in Tourette syndrome.
2045-2322
Brandt, Valerie C.
e41f5832-70e4-407d-8a15-85b861761656
Stock, Ann-Kathrin
dfa52f5c-ba57-4158-93fa-9bacc5f15433
Münchau, Alexander
bba98d7f-0c1a-48b7-8a9d-e021d967ea74
Beste, Christian
89346db7-e24b-4239-bc28-7f395e24644a
Brandt, Valerie C.
e41f5832-70e4-407d-8a15-85b861761656
Stock, Ann-Kathrin
dfa52f5c-ba57-4158-93fa-9bacc5f15433
Münchau, Alexander
bba98d7f-0c1a-48b7-8a9d-e021d967ea74
Beste, Christian
89346db7-e24b-4239-bc28-7f395e24644a

Brandt, Valerie C., Stock, Ann-Kathrin, Münchau, Alexander and Beste, Christian (2017) Evidence for enhanced multi-component behaviour in Tourette syndrome - an EEG study. Scientific Reports, 7. (doi:10.1038/s41598-017-08158-9).

Record type: Article

Abstract

Evidence suggests that Tourette syndrome is characterized by an increase in dopamine transmission and structural as well as functional changes in fronto-striatal circuits that might lead to enhanced multi-component behaviour integration. Behavioural and neurophysiological data regarding multi-component behaviour was collected from 15 patients with Tourette syndrome (mean age = 30.40 ± 11.10) and 15 healthy controls (27.07 ± 5.44), using the stop-change task. In this task, participants are asked to sometimes withhold responses to a Go stimulus (stop cue) and change hands to respond to an alternative Go stimulus (change cue). Different onset asynchronies between stop and change cues were implemented (0 and 300 ms) in order to vary task difficulty. Tourette patients responded more accurately than healthy controls when there was no delay between stop and change stimulus, while there was no difference in the 300 ms delay condition. This performance advantage was reflected in a smaller P3 event related potential. Enhanced multi-component behaviour in Tourette syndrome is likely based on an enhanced ability to integrate information from multiple sources and translate it into an appropriate response sequence. This may be a consequence of chronic tic control in these patients, or a known fronto-striatal networks hyperconnectivity in Tourette syndrome.

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Evidence for enhanced multi-component behaviour in Tourette syndrome - Accepted Manuscript
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More information

Accepted/In Press date: 7 July 2017
e-pub ahead of print date: 10 August 2017

Identifiers

Local EPrints ID: 415709
URI: https://eprints.soton.ac.uk/id/eprint/415709
ISSN: 2045-2322
PURE UUID: 931aa20e-16f8-442a-91d9-9919decadd23

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Date deposited: 20 Nov 2017 17:31
Last modified: 14 Aug 2019 17:24

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Contributors

Author: Ann-Kathrin Stock
Author: Alexander Münchau
Author: Christian Beste

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