Survival at the brink: Chromatin autophagy of tumor cells in response to genotoxic challenge
Survival at the brink: Chromatin autophagy of tumor cells in response to genotoxic challenge
Survival of tumor cells after genotoxic damage, in particular those lacking TP53, requires a sophisticated series of cellular processes and ultrastructural reorganizations. Together these operations help to overcome the paradox between cellular senescence, high levels of DNA damage and the renewal of stemness.
Recently we reported that autophagic chromatin elimination is a key component of the survival response. In this chapter, we detail the many ways in which chromatin autophagy can occur in tumor cells, discuss its evolutionary precursors, and reveal how it may help to determine cell fate.
275-294
Erenpreisa, Jekaterina
70b5fecb-7208-431f-bd35-ec498edc0033
Salmina, Kristine
00a98b4d-8de8-4e78-99f7-a8834851d209
Belyayev, Alexander
af902959-0ef3-46c3-9993-e4c892be45f8
Inashkina, Inna
24b235f4-a65e-4e63-ba8f-17bfecfa4e4e
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
2017
Erenpreisa, Jekaterina
70b5fecb-7208-431f-bd35-ec498edc0033
Salmina, Kristine
00a98b4d-8de8-4e78-99f7-a8834851d209
Belyayev, Alexander
af902959-0ef3-46c3-9993-e4c892be45f8
Inashkina, Inna
24b235f4-a65e-4e63-ba8f-17bfecfa4e4e
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Erenpreisa, Jekaterina, Salmina, Kristine, Belyayev, Alexander, Inashkina, Inna and Cragg, Mark S.
(2017)
Survival at the brink: Chromatin autophagy of tumor cells in response to genotoxic challenge.
In,
Hayat, M.
(ed.)
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging.
Academic Press, .
(doi:10.1016/B978-0-12-812146-7.00012-3).
Record type:
Book Section
Abstract
Survival of tumor cells after genotoxic damage, in particular those lacking TP53, requires a sophisticated series of cellular processes and ultrastructural reorganizations. Together these operations help to overcome the paradox between cellular senescence, high levels of DNA damage and the renewal of stemness.
Recently we reported that autophagic chromatin elimination is a key component of the survival response. In this chapter, we detail the many ways in which chromatin autophagy can occur in tumor cells, discuss its evolutionary precursors, and reveal how it may help to determine cell fate.
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More information
Accepted/In Press date: 25 August 2017
e-pub ahead of print date: 15 September 2017
Published date: 2017
Identifiers
Local EPrints ID: 415803
URI: http://eprints.soton.ac.uk/id/eprint/415803
PURE UUID: 4e727f54-ddae-4bf8-b500-2bda00b95812
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Date deposited: 24 Nov 2017 17:30
Last modified: 16 Mar 2024 02:58
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Contributors
Author:
Jekaterina Erenpreisa
Author:
Kristine Salmina
Author:
Alexander Belyayev
Author:
Inna Inashkina
Editor:
M. Hayat
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