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Survival at the brink: Chromatin autophagy of tumor cells in response to genotoxic challenge

Survival at the brink: Chromatin autophagy of tumor cells in response to genotoxic challenge
Survival at the brink: Chromatin autophagy of tumor cells in response to genotoxic challenge
Survival of tumor cells after genotoxic damage, in particular those lacking TP53, requires a sophisticated series of cellular processes and ultrastructural reorganizations. Together these operations help to overcome the paradox between cellular senescence, high levels of DNA damage and the renewal of stemness.

Recently we reported that autophagic chromatin elimination is a key component of the survival response. In this chapter, we detail the many ways in which chromatin autophagy can occur in tumor cells, discuss its evolutionary precursors, and reveal how it may help to determine cell fate.
275-294
Academic Press
Erenpreisa, Jekaterina
70b5fecb-7208-431f-bd35-ec498edc0033
Salmina, Kristine
00a98b4d-8de8-4e78-99f7-a8834851d209
Belyayev, Alexander
af902959-0ef3-46c3-9993-e4c892be45f8
Inashkina, Inna
24b235f4-a65e-4e63-ba8f-17bfecfa4e4e
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Hayat, M.
Erenpreisa, Jekaterina
70b5fecb-7208-431f-bd35-ec498edc0033
Salmina, Kristine
00a98b4d-8de8-4e78-99f7-a8834851d209
Belyayev, Alexander
af902959-0ef3-46c3-9993-e4c892be45f8
Inashkina, Inna
24b235f4-a65e-4e63-ba8f-17bfecfa4e4e
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Hayat, M.

Erenpreisa, Jekaterina, Salmina, Kristine, Belyayev, Alexander, Inashkina, Inna and Cragg, Mark S. (2017) Survival at the brink: Chromatin autophagy of tumor cells in response to genotoxic challenge. In, Hayat, M. (ed.) Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Academic Press, pp. 275-294. (doi:10.1016/B978-0-12-812146-7.00012-3).

Record type: Book Section

Abstract

Survival of tumor cells after genotoxic damage, in particular those lacking TP53, requires a sophisticated series of cellular processes and ultrastructural reorganizations. Together these operations help to overcome the paradox between cellular senescence, high levels of DNA damage and the renewal of stemness.

Recently we reported that autophagic chromatin elimination is a key component of the survival response. In this chapter, we detail the many ways in which chromatin autophagy can occur in tumor cells, discuss its evolutionary precursors, and reveal how it may help to determine cell fate.

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More information

Accepted/In Press date: 25 August 2017
e-pub ahead of print date: 15 September 2017
Published date: 2017

Identifiers

Local EPrints ID: 415803
URI: http://eprints.soton.ac.uk/id/eprint/415803
PURE UUID: 4e727f54-ddae-4bf8-b500-2bda00b95812
ORCID for Mark S. Cragg: ORCID iD orcid.org/0000-0003-2077-089X

Catalogue record

Date deposited: 24 Nov 2017 17:30
Last modified: 26 Nov 2021 02:40

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Contributors

Author: Jekaterina Erenpreisa
Author: Kristine Salmina
Author: Alexander Belyayev
Author: Inna Inashkina
Author: Mark S. Cragg ORCID iD
Editor: M. Hayat

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