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Frontal evoked γ activity modulates behavioural performance in Autism Spectrum Disorders in a perceptual simultaneity task

Frontal evoked γ activity modulates behavioural performance in Autism Spectrum Disorders in a perceptual simultaneity task
Frontal evoked γ activity modulates behavioural performance in Autism Spectrum Disorders in a perceptual simultaneity task
Autism spectrum disorders (ASDs) are associated with anomalies in time perception. In a perceptual simultaneity task, individuals with ASD demonstrate superior performance compared to typically developing (TD) controls. γ-activity, a robust marker of visual processing, is reportedly altered in ASD in response to a wide variety of tasks and these differences may be related to superior performance in perceptual simultaneity. Using time-frequency analysis, we assessed evoked γ-band phase-locking in magnetoencephalographic recordings of 16 ASD individuals and 17 age-matched TD controls. Individuals judged whether presented visual stimuli were simultaneous or asynchronous. We identified left frontal γ-activity in ASD, which was associated with a reduced perception of simultaneity. Where feature binding was observed at a neurophysiological level in parieto-occipital cortices in ASD in apparent simultaneity (asynchronous stimuli with short delay between them), this did not predict the correct behavioural outcome. These findings suggest distinct γ profiles in ASD associated with the perception of simultaneity.

Abbreviations

ADI-R, Autism Diagnostic Interview Revised;
ADOS-G, Autism Diagnostic Observation Schedule Generic;
ANOVA, analysis of variance;
ASD, Autism Spectrum Disorders;
DSM-V, diagnostic and statistical manual for mental disorders, fifth edition;
MEG, magnetoencephalography;
PCA, principal component analysis;
TD, typicallydeveloping;
WASI, Wechsler Abbreviated Scale of Intelligence
0304-3940
86-91
Menassa, David A.
eeb394a6-c72b-49d7-a820-95b0256c22d5
Braeutigam, Sven
0a717f74-6ef2-49b0-b558-4ef1ad45cb00
Bailey, Anthony
0b5b9dc1-54eb-4655-a234-528b51220222
Falter-Wagner, Christine M.
d249d0cd-09c2-4270-aedc-a75a6085906b
Menassa, David A.
eeb394a6-c72b-49d7-a820-95b0256c22d5
Braeutigam, Sven
0a717f74-6ef2-49b0-b558-4ef1ad45cb00
Bailey, Anthony
0b5b9dc1-54eb-4655-a234-528b51220222
Falter-Wagner, Christine M.
d249d0cd-09c2-4270-aedc-a75a6085906b

Menassa, David A., Braeutigam, Sven, Bailey, Anthony and Falter-Wagner, Christine M. (2018) Frontal evoked γ activity modulates behavioural performance in Autism Spectrum Disorders in a perceptual simultaneity task Neuroscience Letters, 665, pp. 86-91. (doi:10.1016/j.neulet.2017.11.045).

Record type: Article

Abstract

Autism spectrum disorders (ASDs) are associated with anomalies in time perception. In a perceptual simultaneity task, individuals with ASD demonstrate superior performance compared to typically developing (TD) controls. γ-activity, a robust marker of visual processing, is reportedly altered in ASD in response to a wide variety of tasks and these differences may be related to superior performance in perceptual simultaneity. Using time-frequency analysis, we assessed evoked γ-band phase-locking in magnetoencephalographic recordings of 16 ASD individuals and 17 age-matched TD controls. Individuals judged whether presented visual stimuli were simultaneous or asynchronous. We identified left frontal γ-activity in ASD, which was associated with a reduced perception of simultaneity. Where feature binding was observed at a neurophysiological level in parieto-occipital cortices in ASD in apparent simultaneity (asynchronous stimuli with short delay between them), this did not predict the correct behavioural outcome. These findings suggest distinct γ profiles in ASD associated with the perception of simultaneity.

Abbreviations

ADI-R, Autism Diagnostic Interview Revised;
ADOS-G, Autism Diagnostic Observation Schedule Generic;
ANOVA, analysis of variance;
ASD, Autism Spectrum Disorders;
DSM-V, diagnostic and statistical manual for mental disorders, fifth edition;
MEG, magnetoencephalography;
PCA, principal component analysis;
TD, typicallydeveloping;
WASI, Wechsler Abbreviated Scale of Intelligence

Text NSL_MenassaBraeutigam_Final_Accepted_Manuscript - Accepted Manuscript
Restricted to Repository staff only until 28 November 2018.
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Accepted/In Press date: 21 November 2017
e-pub ahead of print date: 27 November 2017
Published date: 5 February 2018

Identifiers

Local EPrints ID: 416006
URI: https://eprints.soton.ac.uk/id/eprint/416006
ISSN: 0304-3940
PURE UUID: 7597baa6-4620-4e61-9f7c-489bc797daf2

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Date deposited: 30 Nov 2017 17:30
Last modified: 05 Feb 2018 17:30

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Contributors

Author: Sven Braeutigam
Author: Anthony Bailey
Author: Christine M. Falter-Wagner

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