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D3 receptor expression within the basal ganglia is not affected by Parkinson's disease

D3 receptor expression within the basal ganglia is not affected by Parkinson's disease
D3 receptor expression within the basal ganglia is not affected by Parkinson's disease

Quantitative receptor autoradiography and in situ hybridization were used to investigate the expression of dopamine D3 receptors in sections of human brain containing limbic (nucleus accumbens) and striatal (caudate nucleus, putamen) regions. High levels of dopamine D3 receptor mRNA and specific [3H](+/-)7-hydroxy-N,N-di-N-propyl-2-aminotetralin ([3H]7-OH-DPAT) binding sites were detected in the nucleus accumbens with lower levels in the caudate nucleus and putamen. No difference in D3 receptor expression was observed between normal and parkinsonian brain. These results indicate that D3 receptor expression is not altered in Parkinson's disease. In addition, they suggest that dopamine release in striatal and limbic areas is not necessary for maintenance of D3 receptor expression.

Aged, Aged, 80 and over, Autoradiography, Basal Ganglia, Dopamine Agonists, Female, Humans, In Situ Hybridization, Male, Middle Aged, Oligodeoxyribonucleotides, Parkinson Disease, RNA, Messenger, Receptors, Dopamine D2, Receptors, Dopamine D3, Tetrahydronaphthalenes, Journal Article, Research Support, Non-U.S. Gov't
0304-3940
75-8
Hurley, Michael J.
07b0180f-8e32-4ce1-8185-e046a42ef15a
Stubbs, Carole M.
1f1b9c08-92b5-41b8-80e9-8c0f26e41544
Jenner, Peter
785c25df-ec64-4181-b057-26dd31cd9d84
Marsden, C. David
a9cff237-9d78-4a9f-82e9-a067b47f2472
Hurley, Michael J.
07b0180f-8e32-4ce1-8185-e046a42ef15a
Stubbs, Carole M.
1f1b9c08-92b5-41b8-80e9-8c0f26e41544
Jenner, Peter
785c25df-ec64-4181-b057-26dd31cd9d84
Marsden, C. David
a9cff237-9d78-4a9f-82e9-a067b47f2472

Hurley, Michael J., Stubbs, Carole M., Jenner, Peter and Marsden, C. David (1996) D3 receptor expression within the basal ganglia is not affected by Parkinson's disease. Neuroscience Letters, 214 (2-3), 75-8. (doi:10.1016/0304-3940(96)12884-6).

Record type: Article

Abstract

Quantitative receptor autoradiography and in situ hybridization were used to investigate the expression of dopamine D3 receptors in sections of human brain containing limbic (nucleus accumbens) and striatal (caudate nucleus, putamen) regions. High levels of dopamine D3 receptor mRNA and specific [3H](+/-)7-hydroxy-N,N-di-N-propyl-2-aminotetralin ([3H]7-OH-DPAT) binding sites were detected in the nucleus accumbens with lower levels in the caudate nucleus and putamen. No difference in D3 receptor expression was observed between normal and parkinsonian brain. These results indicate that D3 receptor expression is not altered in Parkinson's disease. In addition, they suggest that dopamine release in striatal and limbic areas is not necessary for maintenance of D3 receptor expression.

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More information

Published date: 23 August 1996
Keywords: Aged, Aged, 80 and over, Autoradiography, Basal Ganglia, Dopamine Agonists, Female, Humans, In Situ Hybridization, Male, Middle Aged, Oligodeoxyribonucleotides, Parkinson Disease, RNA, Messenger, Receptors, Dopamine D2, Receptors, Dopamine D3, Tetrahydronaphthalenes, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 416138
URI: https://eprints.soton.ac.uk/id/eprint/416138
ISSN: 0304-3940
PURE UUID: 65a8fca3-87ee-4b86-a7d7-2481244f4f7a

Catalogue record

Date deposited: 06 Dec 2017 17:30
Last modified: 13 Mar 2019 19:08

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