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Dopamine D3 receptors in the basal ganglia of the common marmoset and following MPTP and L-DOPA treatment

Dopamine D3 receptors in the basal ganglia of the common marmoset and following MPTP and L-DOPA treatment
Dopamine D3 receptors in the basal ganglia of the common marmoset and following MPTP and L-DOPA treatment

The distribution of the dopamine D3 receptor was studied by receptor autoradiography using [3H]7-OH-DPAT in striatal and extrastriatal brain regions of the common marmoset (Callithrix jacchus). Saturation studies demonstrated that [3H]7-OH-DPAT bound with similar affinity to different regions of marmoset brain. In normal marmosets, specific [3H]7-OH-DPAT binding was found in both striatal and extrastriatal regions. Very high levels of specific [3H]7-OH-DPAT binding were detected in the islands of Calleja and nucleus accumbens but in addition high levels of binding were detected in rostral caudate nucleus and putamen. In common marmosets treated with the selective nigral neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the levels of specific [3H]7-OH-DPAT binding in striatal and extrastriatal regions were not different to those in normal animals. Chronic treatment of MPTP-treated marmosets with L-DOPA/ carbidopa did not alter the levels of specific [3H]7-OH-DPAT binding in any brain region. These results demonstrate that in common marmosets D3 receptors are located in both striatal and limbic regions. The receptor density is not altered by dopaminergic denervation or by chronic L-DOPA administration. The D3 receptor may, therefore, be important in both the therapeutic and adverse effects of drugs used to treat Parkinson's disease.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Autoradiography, Basal Ganglia, Callithrix, Dopamine Agents, Female, Levodopa, Male, Receptors, Dopamine D2, Receptors, Dopamine D3, Tissue Distribution, Journal Article, Research Support, Non-U.S. Gov't
0006-8993
259-64
Hurley, Michael J.
07b0180f-8e32-4ce1-8185-e046a42ef15a
Jolkkonen, Jukka
9064e66f-0567-4f95-be10-a6d2ee8a764f
Stubbs, Carole M.
1f1b9c08-92b5-41b8-80e9-8c0f26e41544
Jenner, Peter
785c25df-ec64-4181-b057-26dd31cd9d84
Marsden, C. David
a9cff237-9d78-4a9f-82e9-a067b47f2472
Hurley, Michael J.
07b0180f-8e32-4ce1-8185-e046a42ef15a
Jolkkonen, Jukka
9064e66f-0567-4f95-be10-a6d2ee8a764f
Stubbs, Carole M.
1f1b9c08-92b5-41b8-80e9-8c0f26e41544
Jenner, Peter
785c25df-ec64-4181-b057-26dd31cd9d84
Marsden, C. David
a9cff237-9d78-4a9f-82e9-a067b47f2472

Hurley, Michael J., Jolkkonen, Jukka, Stubbs, Carole M., Jenner, Peter and Marsden, C. David (1996) Dopamine D3 receptors in the basal ganglia of the common marmoset and following MPTP and L-DOPA treatment. Brain Research, 709 (2), 259-64. (doi:10.1016/0006-8993(95)01309-1).

Record type: Article

Abstract

The distribution of the dopamine D3 receptor was studied by receptor autoradiography using [3H]7-OH-DPAT in striatal and extrastriatal brain regions of the common marmoset (Callithrix jacchus). Saturation studies demonstrated that [3H]7-OH-DPAT bound with similar affinity to different regions of marmoset brain. In normal marmosets, specific [3H]7-OH-DPAT binding was found in both striatal and extrastriatal regions. Very high levels of specific [3H]7-OH-DPAT binding were detected in the islands of Calleja and nucleus accumbens but in addition high levels of binding were detected in rostral caudate nucleus and putamen. In common marmosets treated with the selective nigral neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the levels of specific [3H]7-OH-DPAT binding in striatal and extrastriatal regions were not different to those in normal animals. Chronic treatment of MPTP-treated marmosets with L-DOPA/ carbidopa did not alter the levels of specific [3H]7-OH-DPAT binding in any brain region. These results demonstrate that in common marmosets D3 receptors are located in both striatal and limbic regions. The receptor density is not altered by dopaminergic denervation or by chronic L-DOPA administration. The D3 receptor may, therefore, be important in both the therapeutic and adverse effects of drugs used to treat Parkinson's disease.

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More information

Published date: 19 February 1996
Keywords: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Autoradiography, Basal Ganglia, Callithrix, Dopamine Agents, Female, Levodopa, Male, Receptors, Dopamine D2, Receptors, Dopamine D3, Tissue Distribution, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 416139
URI: https://eprints.soton.ac.uk/id/eprint/416139
ISSN: 0006-8993
PURE UUID: 9e528e28-87d4-41eb-ab4b-28b1acce2351

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Date deposited: 06 Dec 2017 17:30
Last modified: 13 Mar 2019 19:08

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