The University of Southampton
University of Southampton Institutional Repository

Effect of chronic treatment with typical and atypical neuroleptics on the expression of dopamine D2 and D3 receptors in rat brain

Effect of chronic treatment with typical and atypical neuroleptics on the expression of dopamine D2 and D3 receptors in rat brain
Effect of chronic treatment with typical and atypical neuroleptics on the expression of dopamine D2 and D3 receptors in rat brain

The effect of chronic treatment (21 days) with typical and atypical neuroleptics on the expression of striatal and limbic D2 and D3 dopamine receptors was investigated in rat brain by in situ hybridization and receptor autoradiography. Haloperidol and sulpiride increased D2 receptor expression in striatal and limbic areas. In contrast, clozapine had no effect on D2 receptor expression. Haloperidol decreased D3 receptor expression in limbic areas, with the exception of the islands of Calleja where an increase occurred. Sulpiride and clozapine increased D3 receptor expression in limbic and striatal regions but decreased D3 receptor expression in the islands of Calleja. This study demonstrates that chronic treatment with typical and atypical neuroleptics produces different regionally specific changes in limbic and striatal D2 and D3 receptor expression. The alterations in dopamine receptor expression were different for each drug, but a distinction between the effects of atypical and typical neuroleptics could be made. Comparison of mRNA levels in animals which were not withdrawn from drug treatment with those that were withdrawn, demonstrated that some changes in receptor expression occurred during drug treatment, whilst others only manifested when drug treatment had ceased. The different regulation of dopamine D2 and D3 receptor expression by typical and atypical neuroleptics may have relevance to the ability of these drugs to cause extrapyramidal side-effects.

Animals, Antipsychotic Agents, Clozapine, Haloperidol, In Situ Hybridization, Limbic System, Male, Neostriatum, RNA, Messenger, Rats, Rats, Sprague-Dawley, Receptors, Dopamine D2, Receptors, Dopamine D3, Sulpiride, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
0033-3158
362-70
Hurley, Michael J.
07b0180f-8e32-4ce1-8185-e046a42ef15a
Stubbs, Carole M.
1f1b9c08-92b5-41b8-80e9-8c0f26e41544
Jenner, Peter
785c25df-ec64-4181-b057-26dd31cd9d84
Marsden, C. David
a3e9f672-aa75-4109-a1d5-6d0740e56220
Hurley, Michael J.
07b0180f-8e32-4ce1-8185-e046a42ef15a
Stubbs, Carole M.
1f1b9c08-92b5-41b8-80e9-8c0f26e41544
Jenner, Peter
785c25df-ec64-4181-b057-26dd31cd9d84
Marsden, C. David
a3e9f672-aa75-4109-a1d5-6d0740e56220

Hurley, Michael J., Stubbs, Carole M., Jenner, Peter and Marsden, C. David (1996) Effect of chronic treatment with typical and atypical neuroleptics on the expression of dopamine D2 and D3 receptors in rat brain. Psychopharmacology, 128 (4), 362-70. (doi:10.1007/s002130050146 .).

Record type: Article

Abstract

The effect of chronic treatment (21 days) with typical and atypical neuroleptics on the expression of striatal and limbic D2 and D3 dopamine receptors was investigated in rat brain by in situ hybridization and receptor autoradiography. Haloperidol and sulpiride increased D2 receptor expression in striatal and limbic areas. In contrast, clozapine had no effect on D2 receptor expression. Haloperidol decreased D3 receptor expression in limbic areas, with the exception of the islands of Calleja where an increase occurred. Sulpiride and clozapine increased D3 receptor expression in limbic and striatal regions but decreased D3 receptor expression in the islands of Calleja. This study demonstrates that chronic treatment with typical and atypical neuroleptics produces different regionally specific changes in limbic and striatal D2 and D3 receptor expression. The alterations in dopamine receptor expression were different for each drug, but a distinction between the effects of atypical and typical neuroleptics could be made. Comparison of mRNA levels in animals which were not withdrawn from drug treatment with those that were withdrawn, demonstrated that some changes in receptor expression occurred during drug treatment, whilst others only manifested when drug treatment had ceased. The different regulation of dopamine D2 and D3 receptor expression by typical and atypical neuroleptics may have relevance to the ability of these drugs to cause extrapyramidal side-effects.

Full text not available from this repository.

More information

Published date: December 1996
Keywords: Animals, Antipsychotic Agents, Clozapine, Haloperidol, In Situ Hybridization, Limbic System, Male, Neostriatum, RNA, Messenger, Rats, Rats, Sprague-Dawley, Receptors, Dopamine D2, Receptors, Dopamine D3, Sulpiride, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 416140
URI: https://eprints.soton.ac.uk/id/eprint/416140
ISSN: 0033-3158
PURE UUID: 8dbf1cc6-36a8-4948-8b52-172eb2d23b24

Catalogue record

Date deposited: 06 Dec 2017 17:30
Last modified: 13 Mar 2019 19:08

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×