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Influenza burden, prevention and treatment in asthma – a scoping review by the EAACI Influenza in Asthma Task Force

Influenza burden, prevention and treatment in asthma – a scoping review by the EAACI Influenza in Asthma Task Force
Influenza burden, prevention and treatment in asthma – a scoping review by the EAACI Influenza in Asthma Task Force
To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma. The strongest evidence of an association was seen in studies of children. Countries in the European Union currently recommend influenza vaccination of adults with asthma; however, coverage varied between regions. Coverage was lower among children with asthma. Limited data suggest that good seroprotection and seroconversion can be achieved in both children and adults with asthma and that vaccination confers a degree of protection against influenza illness and asthma related morbidity to children with asthma. There were insufficient data to determine efficacy in adults. Overall, influenza vaccines appeared to be safe for people with asthma. We identify knowledge gaps and make recommendations on future research needs in relation to influenza in patients with asthma.
0105-4538
Schwarze, Jürgen
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Openshaw, Peter
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Jha, Akhilesh
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Del Giacco, Stefano
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Firinu, Davide
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Tsilochristou, Olympia
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Roberts, Graham
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Selby, Anna
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Akdis, Cezmi
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Agache, Ioana
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Custovic, Adnan
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Heffler, Enrico
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Pinna, Georgia
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Khaitov, Musa
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Nikonova, Alexandra
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Papadopoulos, Nikolaos
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Akhlaq, Ather
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Nurmatov, Ulugbek
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Renz, Harald
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Sheikh, Aziz
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Skevaki, Chrysanthi
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Schwarze, Jürgen
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Openshaw, Peter
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Jha, Akhilesh
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Del Giacco, Stefano
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Firinu, Davide
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Tsilochristou, Olympia
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Roberts, Graham
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Selby, Anna
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Akdis, Cezmi
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Agache, Ioana
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Custovic, Adnan
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Heffler, Enrico
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Pinna, Georgia
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Khaitov, Musa
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Nikonova, Alexandra
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Papadopoulos, Nikolaos
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Akhlaq, Ather
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Nurmatov, Ulugbek
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Renz, Harald
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Sheikh, Aziz
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Skevaki, Chrysanthi
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Schwarze, Jürgen, Openshaw, Peter, Jha, Akhilesh, Del Giacco, Stefano, Firinu, Davide, Tsilochristou, Olympia, Roberts, Graham, Selby, Anna, Akdis, Cezmi, Agache, Ioana, Custovic, Adnan, Heffler, Enrico, Pinna, Georgia, Khaitov, Musa, Nikonova, Alexandra, Papadopoulos, Nikolaos, Akhlaq, Ather, Nurmatov, Ulugbek, Renz, Harald, Sheikh, Aziz and Skevaki, Chrysanthi (2017) Influenza burden, prevention and treatment in asthma – a scoping review by the EAACI Influenza in Asthma Task Force. Allergy. (doi:10.1111/all.13333).

Record type: Article

Abstract

To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma. The strongest evidence of an association was seen in studies of children. Countries in the European Union currently recommend influenza vaccination of adults with asthma; however, coverage varied between regions. Coverage was lower among children with asthma. Limited data suggest that good seroprotection and seroconversion can be achieved in both children and adults with asthma and that vaccination confers a degree of protection against influenza illness and asthma related morbidity to children with asthma. There were insufficient data to determine efficacy in adults. Overall, influenza vaccines appeared to be safe for people with asthma. We identify knowledge gaps and make recommendations on future research needs in relation to influenza in patients with asthma.

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Schwarze_et_al-2017-Allergy - Accepted Manuscript
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Accepted/In Press date: 1 October 2017
e-pub ahead of print date: 6 November 2017

Identifiers

Local EPrints ID: 416154
URI: http://eprints.soton.ac.uk/id/eprint/416154
ISSN: 0105-4538
PURE UUID: 3081567b-19ca-4c75-8c30-bc122dc34cf1
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

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Date deposited: 06 Dec 2017 17:30
Last modified: 22 Nov 2021 05:57

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Contributors

Author: Jürgen Schwarze
Author: Peter Openshaw
Author: Akhilesh Jha
Author: Stefano Del Giacco
Author: Davide Firinu
Author: Olympia Tsilochristou
Author: Graham Roberts ORCID iD
Author: Anna Selby
Author: Cezmi Akdis
Author: Ioana Agache
Author: Adnan Custovic
Author: Enrico Heffler
Author: Georgia Pinna
Author: Musa Khaitov
Author: Alexandra Nikonova
Author: Nikolaos Papadopoulos
Author: Ather Akhlaq
Author: Ulugbek Nurmatov
Author: Harald Renz
Author: Aziz Sheikh
Author: Chrysanthi Skevaki

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