The effects of exercise on pain, fatigue, insomnia, and health perceptions in patients with operable advanced stage rectal cancer prior to surgery: a pilot trial
The effects of exercise on pain, fatigue, insomnia, and health perceptions in patients with operable advanced stage rectal cancer prior to surgery: a pilot trial
Background: Promoting quality of life (QoL) is a key priority in cancer care. We investigated the hypothesis that, in comparison to usual care, exercise post-neoadjuvant chemoradiation therapy/prior to surgical resection will reduce pain, fatigue, and insomnia, and will improve physical and mental health perceptions in patients with locally advanced stage rectal cancer.Methods: In this non-randomized controlled pilot trial, patients in the supervised exercise group (EG; Mage = 64 years;
64% male) and in the control group (CG; Mage = 72 years; 69% male) completed the European Organization for
Research and Treatment of Cancer core Quality of Life questionnaire and the RAND 36-Item Health Survey three
times: pre-neoadjuvant chemoradiation therapy (Time 1; nEC = 24; nCG = 11), post-neoadjuvant chemoradiation
therapy/pre-exercise intervention (Time 2; nEC = 23; nCG = 10), and post-exercise intervention (Time 3; nEC = 22;
nCG = 10). The 6-week exercise intervention was delivered in hospital and comprised of interval aerobic training.
Patients trained in pairs three times per week for 30 to 40 min. Data were analyzed by Mann–Whitney tests and
by Wilcoxon matched-pairs signed-rank tests.Results: No significant between-group differences in changes were found for any of the outcomes. In both groups,
fatigue levels decreased and physical health perceptions increased from pre- to post-exercise intervention. Pain
levels also decreased from pre- to post-exercise intervention, albeit not significantly.Conclusions: The findings from this study can be used to guide a more definitive trial as they provide preliminary
evidence regarding the potential effects of pre-operative exercise on self-reported pain, fatigue, insomnia, and
health perceptions in patients with locally advanced rectal cancer.
1-10
Brunet, Jennifer
445735b2-afed-4ecb-ba14-3c26fc37ded0
Burke, Shaunna
f8879aee-9e8d-4b87-a83c-d393666a470f
Grocott, Michael P. W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
West, Malcolm A.
98b67e58-9875-4133-b236-8a10a0a12c04
Jack, Sandy
3275b6b3-9f60-4901-9b2f-b03aab101638
23 February 2017
Brunet, Jennifer
445735b2-afed-4ecb-ba14-3c26fc37ded0
Burke, Shaunna
f8879aee-9e8d-4b87-a83c-d393666a470f
Grocott, Michael P. W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
West, Malcolm A.
98b67e58-9875-4133-b236-8a10a0a12c04
Jack, Sandy
3275b6b3-9f60-4901-9b2f-b03aab101638
Brunet, Jennifer, Burke, Shaunna, Grocott, Michael P. W., West, Malcolm A. and Jack, Sandy
(2017)
The effects of exercise on pain, fatigue, insomnia, and health perceptions in patients with operable advanced stage rectal cancer prior to surgery: a pilot trial.
BMC cancer, 17, , [153].
(doi:10.1186/s12885-017-3130-y).
Abstract
Background: Promoting quality of life (QoL) is a key priority in cancer care. We investigated the hypothesis that, in comparison to usual care, exercise post-neoadjuvant chemoradiation therapy/prior to surgical resection will reduce pain, fatigue, and insomnia, and will improve physical and mental health perceptions in patients with locally advanced stage rectal cancer.Methods: In this non-randomized controlled pilot trial, patients in the supervised exercise group (EG; Mage = 64 years;
64% male) and in the control group (CG; Mage = 72 years; 69% male) completed the European Organization for
Research and Treatment of Cancer core Quality of Life questionnaire and the RAND 36-Item Health Survey three
times: pre-neoadjuvant chemoradiation therapy (Time 1; nEC = 24; nCG = 11), post-neoadjuvant chemoradiation
therapy/pre-exercise intervention (Time 2; nEC = 23; nCG = 10), and post-exercise intervention (Time 3; nEC = 22;
nCG = 10). The 6-week exercise intervention was delivered in hospital and comprised of interval aerobic training.
Patients trained in pairs three times per week for 30 to 40 min. Data were analyzed by Mann–Whitney tests and
by Wilcoxon matched-pairs signed-rank tests.Results: No significant between-group differences in changes were found for any of the outcomes. In both groups,
fatigue levels decreased and physical health perceptions increased from pre- to post-exercise intervention. Pain
levels also decreased from pre- to post-exercise intervention, albeit not significantly.Conclusions: The findings from this study can be used to guide a more definitive trial as they provide preliminary
evidence regarding the potential effects of pre-operative exercise on self-reported pain, fatigue, insomnia, and
health perceptions in patients with locally advanced rectal cancer.
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Accepted/In Press date: 9 February 2017
e-pub ahead of print date: 23 February 2017
Published date: 23 February 2017
Identifiers
Local EPrints ID: 416179
URI: http://eprints.soton.ac.uk/id/eprint/416179
ISSN: 1471-2407
PURE UUID: 9b0fefb4-c8b6-4168-a4f2-87845dd85977
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Date deposited: 06 Dec 2017 17:30
Last modified: 16 Mar 2024 04:29
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Author:
Jennifer Brunet
Author:
Shaunna Burke
Author:
Sandy Jack
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