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Targeting innate immunity for neurodegenerative disorders of the central nervous system

Targeting innate immunity for neurodegenerative disorders of the central nervous system
Targeting innate immunity for neurodegenerative disorders of the central nervous system

Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview of physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia and astrocyte cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article. Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer's disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview on physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article.

Animals, Astrocytes, Central Nervous System, Humans, Immunity, Innate, Inflammation, Microglia, Neurodegenerative Diseases, Journal Article, Review, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
0022-3042
653-693
Andreasson, Katrin I.
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Bachstetter, Adam D.
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Colonna, Marco
7977d14f-4d4e-47da-8e7e-2f2ccb222534
Ginhoux, Florent
5e22b141-25ef-4c7c-ad2a-accfe10e781d
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Lamb, Bruce
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Landreth, Gary
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Lee, Daniel C.
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Low, Donovan
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Lynch, Marina A.
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Monsonego, Alon
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O'Banion, M. Kerry
05969cb0-9abe-4e48-af53-b956fce6731a
Pekny, Milos
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Puschmann, Till
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Russek-Blum, Niva
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Sandusky, Leslie A.
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Selenica, Maj-Linda B.
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Takata, Kazuyuki
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Teeling, Jessica
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Town, Terrence
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Van Eldik, Linda J.
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Andreasson, Katrin I.
f8d71a53-356b-41f2-b00c-02c48d1e44bc
Bachstetter, Adam D.
ae76e5f2-4358-4479-9cb2-d150cd2b1697
Colonna, Marco
7977d14f-4d4e-47da-8e7e-2f2ccb222534
Ginhoux, Florent
5e22b141-25ef-4c7c-ad2a-accfe10e781d
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Lamb, Bruce
ba329f30-7095-4599-aef9-44000ea9df16
Landreth, Gary
79f3a1db-1daa-422e-ba41-d0dcea516ea6
Lee, Daniel C.
894c3543-aa87-42e0-93d6-8fc8f1273b13
Low, Donovan
66ab72aa-535c-4b91-bb97-cac0963406c3
Lynch, Marina A.
f7e9c356-3f45-45c0-91d0-8db6978acb12
Monsonego, Alon
8934f61f-4081-48e7-880b-296ebff63f5e
O'Banion, M. Kerry
05969cb0-9abe-4e48-af53-b956fce6731a
Pekny, Milos
2fe201de-e074-422c-8d40-fa3e51f3c3dd
Puschmann, Till
a54fa29f-8222-448e-b469-7c1716db3b9e
Russek-Blum, Niva
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Sandusky, Leslie A.
773e1d9b-a6a8-4f09-9b0e-4aacca361f69
Selenica, Maj-Linda B.
f5687b6f-808d-4e71-a7a7-e5cfee2ef06a
Takata, Kazuyuki
b5238ccf-9a49-46aa-811d-0323daa87d30
Teeling, Jessica
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Town, Terrence
68531b27-a2a4-41ef-a1dd-72e0bf235cc7
Van Eldik, Linda J.
f4a15aa6-2afc-44be-842f-9500c8198597

Andreasson, Katrin I., Bachstetter, Adam D., Colonna, Marco, Ginhoux, Florent, Holmes, Clive, Lamb, Bruce, Landreth, Gary, Lee, Daniel C., Low, Donovan, Lynch, Marina A., Monsonego, Alon, O'Banion, M. Kerry, Pekny, Milos, Puschmann, Till, Russek-Blum, Niva, Sandusky, Leslie A., Selenica, Maj-Linda B., Takata, Kazuyuki, Teeling, Jessica, Town, Terrence and Van Eldik, Linda J. (2016) Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of Neurochemistry, 138 (5), 653-693. (doi:10.1111/jnc.13667).

Record type: Article

Abstract

Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview of physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia and astrocyte cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article. Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer's disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview on physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article.

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More information

Accepted/In Press date: 30 April 2016
e-pub ahead of print date: 24 August 2016
Published date: September 2016
Additional Information: © 2016 International Society for Neurochemistry.
Keywords: Animals, Astrocytes, Central Nervous System, Humans, Immunity, Innate, Inflammation, Microglia, Neurodegenerative Diseases, Journal Article, Review, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 416240
URI: https://eprints.soton.ac.uk/id/eprint/416240
ISSN: 0022-3042
PURE UUID: 62795aa5-be9d-4bf9-a712-54d741018b42
ORCID for Clive Holmes: ORCID iD orcid.org/0000-0003-1999-6912

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Date deposited: 08 Dec 2017 17:30
Last modified: 14 Mar 2019 01:48

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Contributors

Author: Katrin I. Andreasson
Author: Adam D. Bachstetter
Author: Marco Colonna
Author: Florent Ginhoux
Author: Clive Holmes ORCID iD
Author: Bruce Lamb
Author: Gary Landreth
Author: Daniel C. Lee
Author: Donovan Low
Author: Marina A. Lynch
Author: Alon Monsonego
Author: M. Kerry O'Banion
Author: Milos Pekny
Author: Till Puschmann
Author: Niva Russek-Blum
Author: Leslie A. Sandusky
Author: Maj-Linda B. Selenica
Author: Kazuyuki Takata
Author: Jessica Teeling
Author: Terrence Town
Author: Linda J. Van Eldik

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