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Serum bactericidal antibody response to serogroup C polysaccharide meningococcal vaccination in children with primary antibody deficiencies

Serum bactericidal antibody response to serogroup C polysaccharide meningococcal vaccination in children with primary antibody deficiencies
Serum bactericidal antibody response to serogroup C polysaccharide meningococcal vaccination in children with primary antibody deficiencies

Primary antibody deficiencies are characterized by decreased serum levels of immunoglobulin isotypes and increased susceptibility to infection by various microorganisms including encapsulated bacteria. This study was performed in order to evaluate bactericidal antibody response of these patients to polysaccharide meningococcal vaccine. Twenty-four antibody deficient children of mean age 11.2+/-3.5 years, and 15 sex and age-matched healthy volunteers were enrolled. All subjects received meningococcal polysaccharide vaccine A+C; blood samples were collected before vaccination and 3 weeks after vaccination. Following vaccination, the serum bactericidal antibody (SBA) geometric mean titre was significantly increased compared to the prevaccination level in the patient group (8.98 versus 1.63, P<0.001) and the control group (12.13 versus 1.26, P<0.001). All controls had a protective SBA response (SBA titre of >or=8 post-vaccination or rise of >or=4-fold from pre- to post-vaccination), whereas only 16 of 24 patients (66.6%) had a protective response (P=0.014). The non-responder patients included 5 cases with common variable immunodeficiency, two cases with hyper IgM syndrome, and one case with IgG subclass deficiency. This study indicates that some patients with primary antibody deficiencies can produce protective post-vaccination titres similar to the normal population, despite the common perception that patients with primary antibody deficiencies respond poorly to vaccination. This supports the use of polysaccharide-containing vaccines in these patients.

Adolescent, Antibodies, Bacterial, Child, Child, Preschool, Female, Humans, Immunologic Deficiency Syndromes, Male, Meningococcal Vaccines, Microbial Viability, Neisseria meningitidis, Serogroup C, Journal Article, Research Support, Non-U.S. Gov't
0264-410X
5308-5314
Rezaei, Nima
4d41d46e-027a-4e28-bb0d-0e7faa7b9478
Aghamohammadi, Asghar
90ffaeac-a13d-48cc-b3e6-b654bb6a6291
Siadat, Seyed Davar
b4dc0b81-da43-4b62-80fe-3d8842324b69
Nejati, Mehdi
a61f166e-17de-41a6-8cdb-4a79ec4dae15
Ahmadi, Hojat
f81c2c57-aecb-4211-b554-b6d8fbcefa44
Moin, Mostafa
69f612ca-9c59-45c3-9180-6d7d3bab9aec
Pourpak, Zahra
d150a06c-2256-4469-850c-3c53badf9eb3
Kamali, Samineh
05d8a2a0-51bc-4c5b-87a1-df60214fd962
Norouzian, Dariush
211fad42-0dab-4319-864e-2c69c350ba5f
Tabaraei, Bahman
a2e26825-5082-45f2-a2c4-52bcaca01da2
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Rezaei, Nima
4d41d46e-027a-4e28-bb0d-0e7faa7b9478
Aghamohammadi, Asghar
90ffaeac-a13d-48cc-b3e6-b654bb6a6291
Siadat, Seyed Davar
b4dc0b81-da43-4b62-80fe-3d8842324b69
Nejati, Mehdi
a61f166e-17de-41a6-8cdb-4a79ec4dae15
Ahmadi, Hojat
f81c2c57-aecb-4211-b554-b6d8fbcefa44
Moin, Mostafa
69f612ca-9c59-45c3-9180-6d7d3bab9aec
Pourpak, Zahra
d150a06c-2256-4469-850c-3c53badf9eb3
Kamali, Samineh
05d8a2a0-51bc-4c5b-87a1-df60214fd962
Norouzian, Dariush
211fad42-0dab-4319-864e-2c69c350ba5f
Tabaraei, Bahman
a2e26825-5082-45f2-a2c4-52bcaca01da2
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51

Rezaei, Nima, Aghamohammadi, Asghar, Siadat, Seyed Davar, Nejati, Mehdi, Ahmadi, Hojat, Moin, Mostafa, Pourpak, Zahra, Kamali, Samineh, Norouzian, Dariush, Tabaraei, Bahman and Read, Robert C. (2007) Serum bactericidal antibody response to serogroup C polysaccharide meningococcal vaccination in children with primary antibody deficiencies. Vaccine, 25 (29), 5308-5314. (doi:10.1016/j.vaccine.2007.05.021).

Record type: Article

Abstract

Primary antibody deficiencies are characterized by decreased serum levels of immunoglobulin isotypes and increased susceptibility to infection by various microorganisms including encapsulated bacteria. This study was performed in order to evaluate bactericidal antibody response of these patients to polysaccharide meningococcal vaccine. Twenty-four antibody deficient children of mean age 11.2+/-3.5 years, and 15 sex and age-matched healthy volunteers were enrolled. All subjects received meningococcal polysaccharide vaccine A+C; blood samples were collected before vaccination and 3 weeks after vaccination. Following vaccination, the serum bactericidal antibody (SBA) geometric mean titre was significantly increased compared to the prevaccination level in the patient group (8.98 versus 1.63, P<0.001) and the control group (12.13 versus 1.26, P<0.001). All controls had a protective SBA response (SBA titre of >or=8 post-vaccination or rise of >or=4-fold from pre- to post-vaccination), whereas only 16 of 24 patients (66.6%) had a protective response (P=0.014). The non-responder patients included 5 cases with common variable immunodeficiency, two cases with hyper IgM syndrome, and one case with IgG subclass deficiency. This study indicates that some patients with primary antibody deficiencies can produce protective post-vaccination titres similar to the normal population, despite the common perception that patients with primary antibody deficiencies respond poorly to vaccination. This supports the use of polysaccharide-containing vaccines in these patients.

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More information

Accepted/In Press date: 12 May 2007
e-pub ahead of print date: 4 June 2007
Published date: 20 July 2007
Keywords: Adolescent, Antibodies, Bacterial, Child, Child, Preschool, Female, Humans, Immunologic Deficiency Syndromes, Male, Meningococcal Vaccines, Microbial Viability, Neisseria meningitidis, Serogroup C, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 416283
URI: https://eprints.soton.ac.uk/id/eprint/416283
ISSN: 0264-410X
PURE UUID: cd07fb81-89ac-4442-ab58-98561465450e
ORCID for Robert C. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 11 Dec 2017 17:30
Last modified: 20 Jul 2019 00:42

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Contributors

Author: Nima Rezaei
Author: Asghar Aghamohammadi
Author: Seyed Davar Siadat
Author: Mehdi Nejati
Author: Hojat Ahmadi
Author: Mostafa Moin
Author: Zahra Pourpak
Author: Samineh Kamali
Author: Dariush Norouzian
Author: Bahman Tabaraei
Author: Robert C. Read ORCID iD

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