Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms
Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms
Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.
Apoptosis, Cells, Cultured, Humans, Macrophages, Meningitis, Meningococcal, Neisseria meningitidis, Nitric Oxide, Porins, U937 Cells, Journal Article, Research Support, Non-U.S. Gov't
729-733
Tunbridge, Anne J.
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Stevanin, Tania M.
f1504019-7365-4b69-8404-e9df63a5348a
Lee, Margaret
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Marriott, Helen M.
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Moir, James W.B.
f6831b5f-5cfd-4c56-b3cd-6782f413a07f
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Dockrell, David H.
a068c9bf-35b8-4c10-8f91-58639cfeca0b
January 2006
Tunbridge, Anne J.
4f25bd2d-1795-45d1-b4b0-f51300050c4e
Stevanin, Tania M.
f1504019-7365-4b69-8404-e9df63a5348a
Lee, Margaret
a87d108c-c8e3-420c-be05-e7e23ee0619e
Marriott, Helen M.
34ca8904-d637-4081-b34c-12be45ecef9f
Moir, James W.B.
f6831b5f-5cfd-4c56-b3cd-6782f413a07f
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Dockrell, David H.
a068c9bf-35b8-4c10-8f91-58639cfeca0b
Tunbridge, Anne J., Stevanin, Tania M., Lee, Margaret, Marriott, Helen M., Moir, James W.B., Read, Robert C. and Dockrell, David H.
(2006)
Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms.
Infection and Immunity, 74 (1), .
(doi:10.1128/IAI.74.1.729-733.2006).
Abstract
Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.
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Accepted/In Press date: 26 September 2005
e-pub ahead of print date: 1 January 2006
Published date: January 2006
Keywords:
Apoptosis, Cells, Cultured, Humans, Macrophages, Meningitis, Meningococcal, Neisseria meningitidis, Nitric Oxide, Porins, U937 Cells, Journal Article, Research Support, Non-U.S. Gov't
Identifiers
Local EPrints ID: 416310
URI: http://eprints.soton.ac.uk/id/eprint/416310
ISSN: 0019-9567
PURE UUID: a27cfec5-fab5-41d2-a653-adea4be0da8e
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Date deposited: 12 Dec 2017 17:30
Last modified: 16 Mar 2024 04:10
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Contributors
Author:
Anne J. Tunbridge
Author:
Tania M. Stevanin
Author:
Margaret Lee
Author:
Helen M. Marriott
Author:
James W.B. Moir
Author:
David H. Dockrell
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