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HIV-1 infection is associated with altered innate pulmonary immunity

HIV-1 infection is associated with altered innate pulmonary immunity
HIV-1 infection is associated with altered innate pulmonary immunity

We obtained bronchoalveolar lavage (BAL) fluid from 45 Malawian adults, to measure the concentrations of innate pulmonary immune factors that are important in lung defense against infection. Increased concentrations of the beta -chemokine RANTES were found in BAL fluid from the human immunodeficiency virus (HIV)-1-infected subjects, compared with those in BAL fluid from the HIV-1-uninfected control subjects (mean, 86 pg/mL vs. 0 pg/mL; P<.001). Lysozyme concentrations were also elevated in the HIV-1-infected subjects, compared with those in the HIV-1-uninfected control subjects (1.9 mu g/mL vs. 1.1 mu g/mL; P=.03), but were not elevated in the HIV-1-infected subjects who had recently recovered from invasive pneumococcal disease. Concentrations of lactoferrin and secretory leukocyte protease inhibitor (SLPI) were not different when the subjects were compared by HIV-1 serostatus. Concentrations of RANTES (R2=0.68 and P<.0001) and SLPI (R2=0.29 and P=.001) correlated with BAL fluid HIV-1 load but not with plasma HIV-1 load.

Adult, Antibodies, Bacterial, Antibody Specificity, Bacterial Capsules, Bronchoalveolar Lavage Fluid, Chemokine CCL5, Female, HIV Infections, HIV-1, Humans, Immunity, Innate, Immunity, Mucosal, Male, Respiratory Tract Infections, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
0022-1899
1412-1416
Gordon, Stephen B.
e1d3f391-d2b9-4a4f-b7af-ad91cd29d48e
Janoff, Edward N.
c9cbd8c6-a096-430d-985c-444070028fc1
Sloper, Dan
c4c90adb-646e-442f-864a-171ab5d3c450
Zhang, Qibo
930f1a8d-3fbf-446f-9a5f-47bc0f5a1d42
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Zijlstra, Eduard E.
6a049b30-e92d-4ff0-b40f-56ec64979ea6
Finn, Adam
59ac74fa-55a6-448d-9e19-9dd2f4654d4b
Molyneux, Malcolm E
2da5a12a-1c16-49bc-9b13-c068029e9676
Gordon, Stephen B.
e1d3f391-d2b9-4a4f-b7af-ad91cd29d48e
Janoff, Edward N.
c9cbd8c6-a096-430d-985c-444070028fc1
Sloper, Dan
c4c90adb-646e-442f-864a-171ab5d3c450
Zhang, Qibo
930f1a8d-3fbf-446f-9a5f-47bc0f5a1d42
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Zijlstra, Eduard E.
6a049b30-e92d-4ff0-b40f-56ec64979ea6
Finn, Adam
59ac74fa-55a6-448d-9e19-9dd2f4654d4b
Molyneux, Malcolm E
2da5a12a-1c16-49bc-9b13-c068029e9676

Gordon, Stephen B., Janoff, Edward N., Sloper, Dan, Zhang, Qibo, Read, Robert C., Zijlstra, Eduard E., Finn, Adam and Molyneux, Malcolm E (2005) HIV-1 infection is associated with altered innate pulmonary immunity. The Journal of Infectious Diseases, 192 (8), 1412-1416. (doi:10.1086/462428).

Record type: Article

Abstract

We obtained bronchoalveolar lavage (BAL) fluid from 45 Malawian adults, to measure the concentrations of innate pulmonary immune factors that are important in lung defense against infection. Increased concentrations of the beta -chemokine RANTES were found in BAL fluid from the human immunodeficiency virus (HIV)-1-infected subjects, compared with those in BAL fluid from the HIV-1-uninfected control subjects (mean, 86 pg/mL vs. 0 pg/mL; P<.001). Lysozyme concentrations were also elevated in the HIV-1-infected subjects, compared with those in the HIV-1-uninfected control subjects (1.9 mu g/mL vs. 1.1 mu g/mL; P=.03), but were not elevated in the HIV-1-infected subjects who had recently recovered from invasive pneumococcal disease. Concentrations of lactoferrin and secretory leukocyte protease inhibitor (SLPI) were not different when the subjects were compared by HIV-1 serostatus. Concentrations of RANTES (R2=0.68 and P<.0001) and SLPI (R2=0.29 and P=.001) correlated with BAL fluid HIV-1 load but not with plasma HIV-1 load.

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More information

Published date: 15 October 2005
Keywords: Adult, Antibodies, Bacterial, Antibody Specificity, Bacterial Capsules, Bronchoalveolar Lavage Fluid, Chemokine CCL5, Female, HIV Infections, HIV-1, Humans, Immunity, Innate, Immunity, Mucosal, Male, Respiratory Tract Infections, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.

Identifiers

Local EPrints ID: 416383
URI: http://eprints.soton.ac.uk/id/eprint/416383
ISSN: 0022-1899
PURE UUID: af540a69-aa37-4647-a6ff-f6664bcc7c40
ORCID for Robert C. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 14 Dec 2017 17:30
Last modified: 10 Nov 2021 03:30

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Contributors

Author: Stephen B. Gordon
Author: Edward N. Janoff
Author: Dan Sloper
Author: Qibo Zhang
Author: Robert C. Read ORCID iD
Author: Eduard E. Zijlstra
Author: Adam Finn
Author: Malcolm E Molyneux

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