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The potential of microRNAs for stem cell-based therapy for degenerative skeletal diseases

The potential of microRNAs for stem cell-based therapy for degenerative skeletal diseases
The potential of microRNAs for stem cell-based therapy for degenerative skeletal diseases
Purpose of review: degenerative skeletal disorders including osteoarthritis (OA) and osteoporosis (OP) are the result of attenuation of tissue regeneration and lead to painful conditions with limited treatment options. Preventative measures to limit the onset of OA and OP remain a significant unmet clinical need. MicroRNAs (miRNAs) are known to be involved in the differentiation of stem cells, and in combination with stem cell therapy could induce skeletal regeneration and potentially prevent OA and OP onset.

Recent findings: the combination of stem cells and miRNA has been successful at regenerating the bone and cartilage in vivo. MiRNAs, including miR-146b known to be involved in chondrogenic differentiation, could provide innovative targets for stem cell-based therapy, for the repair of articular cartilage defects forestalling the onset of OA or in the generation of a stem cell-based therapy for OP.

Summary: this review discusses the combination of skeletal stem cells (SSCs) and candidate miRNAs for application in a cell-based therapy approach for skeletal regenerative medicine.
263-275
Budd, Emma
b0393d03-0b75-454b-afea-8b395f7d3631
Waddell, Shona
04a26ab3-adb1-46c2-8924-255be0523515
De Andres, Maria C.
54e87e8a-1aa2-4907-a8a0-25d0c15e5e40
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Budd, Emma
b0393d03-0b75-454b-afea-8b395f7d3631
Waddell, Shona
04a26ab3-adb1-46c2-8924-255be0523515
De Andres, Maria C.
54e87e8a-1aa2-4907-a8a0-25d0c15e5e40
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778

Budd, Emma, Waddell, Shona, De Andres, Maria C. and Oreffo, Richard O.C. (2017) The potential of microRNAs for stem cell-based therapy for degenerative skeletal diseases. Current molecular biology reports, 3 (4), 263-275. (doi:10.1007/s40610-017-0076-4).

Record type: Article

Abstract

Purpose of review: degenerative skeletal disorders including osteoarthritis (OA) and osteoporosis (OP) are the result of attenuation of tissue regeneration and lead to painful conditions with limited treatment options. Preventative measures to limit the onset of OA and OP remain a significant unmet clinical need. MicroRNAs (miRNAs) are known to be involved in the differentiation of stem cells, and in combination with stem cell therapy could induce skeletal regeneration and potentially prevent OA and OP onset.

Recent findings: the combination of stem cells and miRNA has been successful at regenerating the bone and cartilage in vivo. MiRNAs, including miR-146b known to be involved in chondrogenic differentiation, could provide innovative targets for stem cell-based therapy, for the repair of articular cartilage defects forestalling the onset of OA or in the generation of a stem cell-based therapy for OP.

Summary: this review discusses the combination of skeletal stem cells (SSCs) and candidate miRNAs for application in a cell-based therapy approach for skeletal regenerative medicine.

Text
10.1007_s40610-017-0076-4 - Version of Record
Available under License Creative Commons Attribution.
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More information

Accepted/In Press date: 9 October 2017
e-pub ahead of print date: 23 October 2017
Published date: December 2017

Identifiers

Local EPrints ID: 416414
URI: http://eprints.soton.ac.uk/id/eprint/416414
PURE UUID: 5d0c7441-107c-455e-aa03-9a8d4ec08ce8
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 15 Dec 2017 17:30
Last modified: 14 Mar 2019 01:48

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