Toll-like receptors in health and disease: complex questions remain
Toll-like receptors in health and disease: complex questions remain
Until recently, the manner in which we respond to pathogens was obscure. It is now clear that a family of proteins, the Toll-like receptors (TLRs),3 contribute to the signal transduction induced by many pathogen-associated molecular patterns (PAMPs), and perhaps also to endogenous damage signals generated at sites of inflammation. Some TLRs act as central integrators of a wide variety of signals, responding to diverse agonists with an apparently common output, while other members of the family show (to date) considerable specificity with regard to their stimuli. However, many questions remain regarding the immunopharmacology of TLRs, their roles in innate immunity, and their manipulation by pathogens.
Animals, Humans, Immunity, Innate, Infection, Membrane Glycoproteins, Receptors, Cell Surface, Signal Transduction, Toll-Like Receptors, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review
1630-1635
Sabroe, Ian
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Read, Robert C.
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Whyte, Moira K.B.
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Dockrell, David H.
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Vogel, Stefanie N.
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Dower, Steven K.
c59b6ed1-57d4-49cb-815c-038a96601ecc
15 August 2003
Sabroe, Ian
4de1d7fc-f0f1-485c-8af3-7f67af94bd36
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Whyte, Moira K.B.
fed8c25b-ced7-4a16-89f3-b93208a63a18
Dockrell, David H.
a068c9bf-35b8-4c10-8f91-58639cfeca0b
Vogel, Stefanie N.
a430fd34-a60c-4969-9ba0-bc34d28d2e13
Dower, Steven K.
c59b6ed1-57d4-49cb-815c-038a96601ecc
Sabroe, Ian, Read, Robert C., Whyte, Moira K.B., Dockrell, David H., Vogel, Stefanie N. and Dower, Steven K.
(2003)
Toll-like receptors in health and disease: complex questions remain.
Journal of Immunology, 171 (4), .
(doi:10.4049/jimmunol.171.4.1630).
Abstract
Until recently, the manner in which we respond to pathogens was obscure. It is now clear that a family of proteins, the Toll-like receptors (TLRs),3 contribute to the signal transduction induced by many pathogen-associated molecular patterns (PAMPs), and perhaps also to endogenous damage signals generated at sites of inflammation. Some TLRs act as central integrators of a wide variety of signals, responding to diverse agonists with an apparently common output, while other members of the family show (to date) considerable specificity with regard to their stimuli. However, many questions remain regarding the immunopharmacology of TLRs, their roles in innate immunity, and their manipulation by pathogens.
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Published date: 15 August 2003
Keywords:
Animals, Humans, Immunity, Innate, Infection, Membrane Glycoproteins, Receptors, Cell Surface, Signal Transduction, Toll-Like Receptors, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review
Identifiers
Local EPrints ID: 416417
URI: http://eprints.soton.ac.uk/id/eprint/416417
ISSN: 0022-1767
PURE UUID: cba158ae-cb80-4d83-b8cb-f467194532bb
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Date deposited: 15 Dec 2017 17:30
Last modified: 16 Mar 2024 04:10
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Author:
Ian Sabroe
Author:
Moira K.B. Whyte
Author:
David H. Dockrell
Author:
Stefanie N. Vogel
Author:
Steven K. Dower
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