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Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults

Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults
Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults

We tested the hypothesis that human immunodeficiency virus (HIV)-infected adults have a specific defect in anti-pneumococcal capsular polysaccharide (Pn-specific) immunoglobulin (Ig) in fluid obtained from the lower respiratory tract. Higher levels of total IgG and IgM were present in bronchoalveolar lavage samples from HIV-infected subjects than in those from HIV-uninfected subjects. Pn-specific IgG and IgM in bronchoalveolar lavage samples were not significantly different between HIV-infected and -uninfected subjects. After pneumococcal infection, HIV-infected patients had higher bronchoalveolar lavage levels of Pn-specific IgG than HIV-infected patients without recent infection (geometric means, 387 vs. 30 ng/mL, P=.001).

AIDS-Related Opportunistic Infections, Adult, Antibodies, Bacterial, Antibody Specificity, Bacterial Capsules, Bronchoalveolar Lavage Fluid, Female, HIV Infections, Humans, Immunoglobulin G, Immunoglobulin M, Lung, Malawi, Male, Pneumococcal Infections, Respiratory Tract Infections, Streptococcus pneumoniae, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
0022-1899
666-670
Gordon, Stephen B.
e1d3f391-d2b9-4a4f-b7af-ad91cd29d48e
Miller, David E.
736fb980-ef02-4e09-bdd3-10cbb15f8539
Day, Richard B.
94d3c576-83cb-4c12-adc0-d7b7d72dedee
Ferry, Tom
b9968737-7e8d-48e1-b20d-611d8f3e973c
Wilkes, David S.
a9e87c02-76aa-4f1e-aa98-35e4874c76f3
Schnizlein-Bick, Carol T.
271d2c56-85b5-43dc-af6d-7e2723ca8605
Zijlstra, Eduard E.
6a049b30-e92d-4ff0-b40f-56ec64979ea6
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Molyneux, Malcolm E.
2da5a12a-1c16-49bc-9b13-c068029e9676
Twigg, Homer L.
6a6c10a3-b4bb-4677-af96-b331d58e8bc2
Gordon, Stephen B.
e1d3f391-d2b9-4a4f-b7af-ad91cd29d48e
Miller, David E.
736fb980-ef02-4e09-bdd3-10cbb15f8539
Day, Richard B.
94d3c576-83cb-4c12-adc0-d7b7d72dedee
Ferry, Tom
b9968737-7e8d-48e1-b20d-611d8f3e973c
Wilkes, David S.
a9e87c02-76aa-4f1e-aa98-35e4874c76f3
Schnizlein-Bick, Carol T.
271d2c56-85b5-43dc-af6d-7e2723ca8605
Zijlstra, Eduard E.
6a049b30-e92d-4ff0-b40f-56ec64979ea6
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Molyneux, Malcolm E.
2da5a12a-1c16-49bc-9b13-c068029e9676
Twigg, Homer L.
6a6c10a3-b4bb-4677-af96-b331d58e8bc2

Gordon, Stephen B., Miller, David E., Day, Richard B., Ferry, Tom, Wilkes, David S., Schnizlein-Bick, Carol T., Zijlstra, Eduard E., Read, Robert C., Molyneux, Malcolm E. and Twigg, Homer L. (2003) Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults. The Journal of Infectious Diseases, 188 (5), 666-670. (doi:10.1086/377480).

Record type: Article

Abstract

We tested the hypothesis that human immunodeficiency virus (HIV)-infected adults have a specific defect in anti-pneumococcal capsular polysaccharide (Pn-specific) immunoglobulin (Ig) in fluid obtained from the lower respiratory tract. Higher levels of total IgG and IgM were present in bronchoalveolar lavage samples from HIV-infected subjects than in those from HIV-uninfected subjects. Pn-specific IgG and IgM in bronchoalveolar lavage samples were not significantly different between HIV-infected and -uninfected subjects. After pneumococcal infection, HIV-infected patients had higher bronchoalveolar lavage levels of Pn-specific IgG than HIV-infected patients without recent infection (geometric means, 387 vs. 30 ng/mL, P=.001).

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More information

Published date: 1 September 2003
Keywords: AIDS-Related Opportunistic Infections, Adult, Antibodies, Bacterial, Antibody Specificity, Bacterial Capsules, Bronchoalveolar Lavage Fluid, Female, HIV Infections, Humans, Immunoglobulin G, Immunoglobulin M, Lung, Malawi, Male, Pneumococcal Infections, Respiratory Tract Infections, Streptococcus pneumoniae, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.

Identifiers

Local EPrints ID: 416418
URI: http://eprints.soton.ac.uk/id/eprint/416418
ISSN: 0022-1899
PURE UUID: baddbd7e-4559-408e-b26a-aeb6890b45c6
ORCID for Robert C. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 15 Dec 2017 17:30
Last modified: 18 Feb 2021 17:18

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