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Luminescent 1,8-naphthalimide-derived ReI complexes: Syntheses, spectroscopy, x-ray structure and preliminary bioimaging in fission yeast cells

Luminescent 1,8-naphthalimide-derived ReI complexes: Syntheses, spectroscopy, x-ray structure and preliminary bioimaging in fission yeast cells
Luminescent 1,8-naphthalimide-derived ReI complexes: Syntheses, spectroscopy, x-ray structure and preliminary bioimaging in fission yeast cells
A series of picolyl-functionalised, fluorescent 1,8-naphthalimide ligands (L) have been synthesised and coordinated to ReI to form luminescent cationic complexes of the general form fac-[Re(phen)(CO)3(L)]BF4. The complexes were characterised by using a range of spectroscopic and analytical techniques. One example of a complex was also characterised in the solid-state by using single-crystal X-ray diffraction, revealing a distorted octahedral coordination sphere at ReI and Re–C/Re–N bond lengths within the expected ranges. All ligands were shown to be fluorescent, with the 4-amino derivatives showing intramolecular charge transfer in the visible region (511–534 nm). The complexes generally showed a mixture of ligand-centred and/or 3MLCT emission depending upon the nature of the coordinated 1,8-naphthalimide ligand. For selected complexes, confocal fluorescence microscopy was undertaken by using fission yeast cells (Schizosaccharomyces pombe) and showed that the structure of the 1,8-naphthalimide ligand influences the uptake and localisation of the rhenium complex.
Fluorescence, Imaging agents, Rhenium, Naphthalimide
1434-1948
5279-5287
Langdon-Jones, Emily E.
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Williams, Catrin F.
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Hayes, Anthony J.
1e4d30da-155d-47d1-8ebc-733efe6ea2f8
Lloyd, David
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Coles, Simon J.
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Horton, Peter N.
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Groves, Lara M.
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Pope, Simon J.A.
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Langdon-Jones, Emily E.
b11f5d82-87fa-4206-9169-8f70826f2070
Williams, Catrin F.
ab7c34b4-3d67-4c1a-acb7-666a9d775f01
Hayes, Anthony J.
1e4d30da-155d-47d1-8ebc-733efe6ea2f8
Lloyd, David
e7a912a2-f666-43d7-aa88-e1d97bb4e77f
Coles, Simon J.
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Horton, Peter N.
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Groves, Lara M.
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Pope, Simon J.A.
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Langdon-Jones, Emily E., Williams, Catrin F., Hayes, Anthony J., Lloyd, David, Coles, Simon J., Horton, Peter N., Groves, Lara M. and Pope, Simon J.A. (2017) Luminescent 1,8-naphthalimide-derived ReI complexes: Syntheses, spectroscopy, x-ray structure and preliminary bioimaging in fission yeast cells. European Journal of Inorganic Chemistry, 2017 (44), 5279-5287. (doi:10.1002/ejic.201700549).

Record type: Article

Abstract

A series of picolyl-functionalised, fluorescent 1,8-naphthalimide ligands (L) have been synthesised and coordinated to ReI to form luminescent cationic complexes of the general form fac-[Re(phen)(CO)3(L)]BF4. The complexes were characterised by using a range of spectroscopic and analytical techniques. One example of a complex was also characterised in the solid-state by using single-crystal X-ray diffraction, revealing a distorted octahedral coordination sphere at ReI and Re–C/Re–N bond lengths within the expected ranges. All ligands were shown to be fluorescent, with the 4-amino derivatives showing intramolecular charge transfer in the visible region (511–534 nm). The complexes generally showed a mixture of ligand-centred and/or 3MLCT emission depending upon the nature of the coordinated 1,8-naphthalimide ligand. For selected complexes, confocal fluorescence microscopy was undertaken by using fission yeast cells (Schizosaccharomyces pombe) and showed that the structure of the 1,8-naphthalimide ligand influences the uptake and localisation of the rhenium complex.

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EJIC_v2 - Accepted Manuscript
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Accepted/In Press date: 21 July 2017
e-pub ahead of print date: 7 September 2017
Published date: December 2017
Keywords: Fluorescence, Imaging agents, Rhenium, Naphthalimide

Identifiers

Local EPrints ID: 416437
URI: http://eprints.soton.ac.uk/id/eprint/416437
ISSN: 1434-1948
PURE UUID: 68a5becc-96c5-49a7-ad4b-567372cf48cc
ORCID for Simon J. Coles: ORCID iD orcid.org/0000-0001-8414-9272
ORCID for Peter N. Horton: ORCID iD orcid.org/0000-0001-8886-2016

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Date deposited: 15 Dec 2017 17:31
Last modified: 16 Mar 2024 05:48

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Contributors

Author: Emily E. Langdon-Jones
Author: Catrin F. Williams
Author: Anthony J. Hayes
Author: David Lloyd
Author: Simon J. Coles ORCID iD
Author: Peter N. Horton ORCID iD
Author: Lara M. Groves
Author: Simon J.A. Pope

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