An individual participant data meta-analysis of 13 randomized trials to evaluate the impact of prophylactic use of heparin in oncological patients
An individual participant data meta-analysis of 13 randomized trials to evaluate the impact of prophylactic use of heparin in oncological patients
Background: Parenteral anticoagulants may improve outcomes in patients with cancer by reducing the risk of venous thromboembolism (VTE) and through a direct anti-tumour effect. Study-level meta-analysis indicates a reduction in VTE and provide moderate certainty that a small survival benefit exists; it is unclear if patients with specific cancers benefit more or less. Utilizing data from randomized controlled trials (RCT), this individual participant data meta-analysis examines the impact of heparin on survival, VTE and major bleeding in oncological patients randomized to low-molecular weight heparin (LMWH) or no LMWH.
Schunemann, Holger
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Ventresca, Matthew
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Crowther, Mark
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Di Nisio, Marcello
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Briel, Matthias
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Zhou, Qi
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Noble, Simon
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Macbeth, Fergus
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Griffiths, Gareth
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Garcia, David
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Lyman, Gary
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Iorio, Alfonso
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Mbuagbaw, Lawrance
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Neumann, Ignacio
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Van Es, Nick
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Brozek, Jan
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Guyatt, Gordon
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Streiff, Michael
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Brouwers, Melissa
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Baldeh, Tejan
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Marcucci, Maura
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Florez, Ivan
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Solh, Ziad
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Ageno, Walter
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Bleker, Suzanne
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Bozas, George
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Buller, Harry
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Klerk, Clara
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Lebeau, Bernard
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Lecumberri, Ramon
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McBane, Robert
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Sideras, Kostandinos
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Maraveyas, Anthony
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Pelzer, Uwe
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Loprinzi, Charles
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Bossuyt, Patrick M.
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Kahale, Lara
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Akl, Elie A.
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Zulian, Gilbert
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11 December 2017
Schunemann, Holger
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Ventresca, Matthew
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Crowther, Mark
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Di Nisio, Marcello
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Briel, Matthias
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Zhou, Qi
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Noble, Simon
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Macbeth, Fergus
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Griffiths, Gareth
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Garcia, David
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Lyman, Gary
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Iorio, Alfonso
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Mbuagbaw, Lawrance
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Neumann, Ignacio
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Van Es, Nick
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Brozek, Jan
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Guyatt, Gordon
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Streiff, Michael
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Brouwers, Melissa
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Baldeh, Tejan
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Marcucci, Maura
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Florez, Ivan
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Solh, Ziad
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Ageno, Walter
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Bleker, Suzanne
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Bozas, George
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Buller, Harry
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Klerk, Clara
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Lebeau, Bernard
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Lecumberri, Ramon
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McBane, Robert
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Sideras, Kostandinos
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Maraveyas, Anthony
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Pelzer, Uwe
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Loprinzi, Charles
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Bossuyt, Patrick M.
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Kahale, Lara
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Akl, Elie A.
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Zulian, Gilbert
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