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Macrophage defences against respiratory tract infections

Macrophage defences against respiratory tract infections
Macrophage defences against respiratory tract infections

Pulmonary macrophages with a key role in defence against respiratory infection are a heterogeneous family of cells with phagocytic, antigen processing and immunomodulatory functions. Macrophages are important in both innate and acquired immunity in the respiratory tract, and have a role in lung defence against viruses, bacteria, mycobacteria and fungi. Interactions of pathogens with lung macrophages is strongly influenced by soluble immune components including complement, collectins and immunoglobulins. Macrophage function can be modulated by cytokines, environmental exposures, recent and chronic infection including HIV infection, drug therapy and gene transfer.

Bacterial Infections, Child, Environmental Pollutants, HIV Infections, Humans, Immunity, Cellular, Macrophage Activation, Macrophages, Alveolar, Mycoses, Respiratory Syncytial Virus Infections, Respiratory Tract Infections, Journal Article, Research Support, Non-U.S. Gov't, Review
0007-1420
45-61
Gordon, S B
d004fb35-bf59-4028-a55f-56eb478706a2
Read, R C
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Gordon, S B
d004fb35-bf59-4028-a55f-56eb478706a2
Read, R C
b5caca7b-0063-438a-b703-7ecbb6fc2b51

Gordon, S B and Read, R C (2002) Macrophage defences against respiratory tract infections. British Medical Bulletin, 61, 45-61. (doi:10.1093/bmb/61.1.45).

Record type: Article

Abstract

Pulmonary macrophages with a key role in defence against respiratory infection are a heterogeneous family of cells with phagocytic, antigen processing and immunomodulatory functions. Macrophages are important in both innate and acquired immunity in the respiratory tract, and have a role in lung defence against viruses, bacteria, mycobacteria and fungi. Interactions of pathogens with lung macrophages is strongly influenced by soluble immune components including complement, collectins and immunoglobulins. Macrophage function can be modulated by cytokines, environmental exposures, recent and chronic infection including HIV infection, drug therapy and gene transfer.

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More information

Published date: 1 March 2002
Keywords: Bacterial Infections, Child, Environmental Pollutants, HIV Infections, Humans, Immunity, Cellular, Macrophage Activation, Macrophages, Alveolar, Mycoses, Respiratory Syncytial Virus Infections, Respiratory Tract Infections, Journal Article, Research Support, Non-U.S. Gov't, Review

Identifiers

Local EPrints ID: 416550
URI: http://eprints.soton.ac.uk/id/eprint/416550
ISSN: 0007-1420
PURE UUID: 25367cf9-7fe7-4427-9d25-af8b94a9e4b9
ORCID for R C Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 21 Dec 2017 17:30
Last modified: 10 Nov 2021 03:30

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Contributors

Author: S B Gordon
Author: R C Read ORCID iD

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